Dr Ping CHEN - Faculty of Health Sciences (FHS)

haydenlam Lam Su Hang2024-10-10T17:24:52+08:002022-09-09|

Contact Information

Title

Research Assistant Professor

Office

(Office) N22-4032

Phone

(Office) +853 8822 4257

Email

pingchen@umac.mo

Consultation Hours

Fri 09:00-13:00, 14:30 – 17:30

Teaching

Education
PhD	Sichuan university (2010)
MMS	Sichuan university (2007)
BSc	Sichuan university (2002)

Position
06/2022 – Present	Research Assistant Professor, Faculty of Health Sciences, University of Macau
06/2017 – 05/2022	Postdoctoral Fellow, Faculty of Health Sciences, University of Macau

Research Interests
Molecular mechanism of cancer resistance to drugs and individualized precise treatment.

Representative Publications
Chen P, Zhang X, Ding R, Yang L, Lyu X, Zeng J, Lei JH, Wang L, Bi J, Shao N, Shu D, Wu B, Wu J, Yang Z, Wang H, Wang B, Xiong K, Lu Y, Fu S, Choi TK, Lon NW, Zhang A, Tang D, Quan Y, Meng Y, Miao K, Sun H, Zhao M, Bao J, Zhang L, Xu X, Shi Y, Lin Y, Deng C. Patient-Derived Organoids Can Guide Personalized-Therapies for Patients with Advanced Breast Cancer. Advanced Science (Weinh). 2021 Oct 4:e2101176. Lei JH, Lee MH, Miao K, Huang Z, Yao Z, Zhang A, Xu J, Zhao M, Huang Z, Zhang X, Chen S, Jiaying NG, Feng Y, Xing F, Chen P, Sun H, Chen Q, Xiang T, Chen L, Xu X, Deng CX. Activation of FGFR2 Signaling Suppresses BRCA1 and Drives Triple-Negative Mammary Tumorigenesis That is Sensitive to Immunotherapy. Advanced Science (Weinh). 2021 Sep 13:e2100974. Ding RB, Chen P, Rajendran BK, Lyu X, Wang H, Bao J, Zeng J, Hao W, Sun H, Wong AH, Valecha MV, Yang EJ, Su SM, Choi TK, Liu S, Chan KI, Yang LL, Wu J, Miao K, Chen Q, Shim JS, Xu X, Deng CX. Molecular landscape and subtype-specific therapeutic response of nasopharyngeal carcinoma revealed by integrative pharmacogenomics. Nature Communications. 2021 May 24;12(1):3046. Peng J, Zhao J, Zhao Y, Wu P, Gou L, Fu S, Chen P, Lu Y, Yang L. HeLa Cell-Derived Paclitaxel-Loaded Microparticles Efficiently Inhibit the Growth of Cervical Carcinoma. Int J Nanomedicine. 2020 Aug 25;15:6409-6420. Shao F, Lyu X, Miao K, Xie L, Wang H, Xiao H, Li J, Chen Q, Ding R, Chen P, Xing F, Zhang X, Luo GH, Zhu W, Cheng G, Lon NW, Martin SE, Wang G, Chen G, Dai Y, Deng CX. Enhanced Protein Damage Clearance Induces Broad Drug Resistance in Multitype of Cancers Revealed by an Evolution Drug-Resistant Model and Genome-Wide siRNA Screening. Advanced Science (Weinh). 2020;7(23):2001914. Miao K, Lei JH, Valecha MV, Zhang A, Xu J, Wang L, Lyu X, Chen S, Miao Z, Zhang X, Su SM, Shao F, Rajendran BK, Bao J, Zeng J, Sun H, Chen P, Tan K, Chen Q, Wong KH, Xu X, Deng CX. NOTCH1 activation compensates BRCA1 deficiency and promotes triple-negative breast cancer formation. Nature Communications. 2020;11(1):3256. Liu J, Zhou J, Wu M, Hu C, Yang J, Li D, Wu P, Chen Y, Chen P, Lin S, Cui Y, Fu S, Wu J. Low-Dose Total Body Irradiation Can Enhance Systemic Immune Related Response Induced by Hypo-Fractionated Radiation. Frontiers in immunology. 2019 Feb 27;10:317. Chen P, Zhang KH, Na T, Wang L, Yin WD, Yuan BZ, Wang JZ. Using Mesenchymal Stem Cells as a Novel, High Yielding and Safe Cell Substrate for the production of Viral Vaccines. Scientific Reports. 2017;7(1):12484. Chen P, Luo S, Wen YJ, Li YH, Li J, Wang YS, Du LC, Zhang P, Tang J, Yang DB, Hu HZ, Zhao X, Wei YQ. Low-dose Paclitaxel Improves the Therapeutic Efficacy of Recombinant Adenovirus Encoding CCL21 Chemokine against Murine Cancer. Cancer Science. 2014;105(11):1393-401. Luo S, Chen P, Luo ZC, et al. Combination of vesicular stomatitis virus matrix protein gene therapy with low-dose cisplatin improves therapeutic efficacy against murine melonoma. Cancer Science. 2010;101(5):1219-25. Fang F, Chen P, Wu X, Yang L, Yang X, Xi ZX, Zhou BW, Zhou XK, Qian ZY, Xiao B, Wei YQ.Therapeutic effects of recombinant human endostatin adenovirus in a mouse model of malignant pleural effusion. Journal of Cancer Research & Clinical Oncology. 2009;135(9):1149-57. Huang AL, Wan Y, Liao DY, Hu HZ, Wei L, Wang XH, Wen YJ, Li J, Chen LJ, Kan B, Chen P, Wang YS, Chen X, Zhao X, Deng HX, Wei YQ. Suppression of human MDA-MB-435S tumor by U6 promoter-driven short hairpin RNAs targeting focal adhesion kinase. Journal of Cancer Research & Clinical Oncology. 2010 Aug;136(8):1229-42. Li J, Wei Y, Liu K, Yuan C, Tang Y, Quan Q, Chen P, Wang W, Hu H, Yang L. Synergistic effects of FGF-2 and PDGF-BB on angiogenesis and muscle regeneration in rabbit hindlimb ischemia model. Microvascular research. 2010;80(1):10-7. Liu L, Deng H, Wang Y, Chen P, Yang Y, Yang H, Chen X, Chen L, Zhu W, Liang S, Yang J, Qian Z, Li J, Wen Y, Kan B, Mao Y, Zhao X, Wei Y. A novel strategy for tumor therapy combining cell apoptosis and active immunity induced by caspy2, a zebrafish caspase. Journal of Cellular and Molecular Medicine. 2009;13(8B):2271-81. Wang YS, Li D, Shi HS, Wen YJ, Yang L, Xu N, Chen XC, Chen X, Chen P, Li J, Deng HX, Wang CT, Xie G, Huang S, Mao YQ, Chen LJ, Zhao X, Wei YQ. Intratumoral expression of mature human neutrophil peptide-1 mediates antitumor immunity in mice. Clinical Cancer Resarch. 2009;15(22):6901-11. Wen J, Fu AF, Chen LJ, Xie XJ, Yang GL, Chen XC, Wang YS, Li J, Chen P, Tang MH, Shao XM, Lu Y, Zhao X, Wei YQ. Liposomal honokiol inhibits VEGF-D- induced lymphangiogenesis and metastasis in xenograft tumor model. International Journal of Cancer. 2009;124(11):2709-18. Chen P, Yang LL, Yang HS, Wang YS, Li G, Wu Y, Fang F, Liu K, Li J, Zhao X, Hu HZ, Wei YQ. Synergistic antitumor effect of CXCL10 with hyperthermia. Journal of Cancer Research & Clinical Oncology. 2008;134(6):679-87. Wang Z, Jiang L, Huang C, Li Z, Chen L, Gou L, Chen P, Tong A, Tang M, Gao F, Shen J, Zhang Y, Bai J, Zhou M, Miao D, Chen Q. Comparative proteomics approach to screening of potential diagnostic and therapeutic targets for oral squamous cell carcinoma. Molecular & Cellular Proteomics. 2008;7(9):1639-50. Tong A, Wu L, Lin Q, Lau QC, Zhao X, Li J, Chen P, Chen L, Tang H, Huang C, Wei YQ.Proteomic analysis of cellular protein alterations using a hepatitis B virus-producing cellular model. Proteomics. 2008;8(10):2012-23. Wang YS, Wang GQ, Wen YJ, Wang L, Chen XC, Chen P, Kan B, Li J, Huang C, Lu Y, Zhou Q, Xu N, Li D, Fan LY, Yi T, Wu HB, Wei YQ. Immunity against tumor angiogenesis induced by a fusion vaccine with murine beta-defensin 2 and mFlk-1. Clinical Cancer Resarch. 2007 Nov 15;13(22 Pt 1):6779-87.

Representative Publications

Chen P, Zhang X, Ding R, Yang L, Lyu X, Zeng J, Lei JH, Wang L, Bi J, Shao N, Shu D, Wu B, Wu J, Yang Z, Wang H, Wang B, Xiong K, Lu Y, Fu S, Choi TK, Lon NW, Zhang A, Tang D, Quan Y, Meng Y, Miao K, Sun H, Zhao M, Bao J, Zhang L, Xu X, Shi Y, Lin Y, Deng C. Patient-Derived Organoids Can Guide Personalized-Therapies for Patients with Advanced Breast Cancer. Advanced Science (Weinh). 2021 Oct 4:e2101176.
Lei JH, Lee MH, Miao K, Huang Z, Yao Z, Zhang A, Xu J, Zhao M, Huang Z, Zhang X, Chen S, Jiaying NG, Feng Y, Xing F, Chen P, Sun H, Chen Q, Xiang T, Chen L, Xu X, Deng CX. Activation of FGFR2 Signaling Suppresses BRCA1 and Drives Triple-Negative Mammary Tumorigenesis That is Sensitive to Immunotherapy. Advanced Science (Weinh). 2021 Sep 13:e2100974.
Ding RB, Chen P, Rajendran BK, Lyu X, Wang H, Bao J, Zeng J, Hao W, Sun H, Wong AH, Valecha MV, Yang EJ, Su SM, Choi TK, Liu S, Chan KI, Yang LL, Wu J, Miao K, Chen Q, Shim JS, Xu X, Deng CX. Molecular landscape and subtype-specific therapeutic response of nasopharyngeal carcinoma revealed by integrative pharmacogenomics. Nature Communications. 2021 May 24;12(1):3046.
Peng J, Zhao J, Zhao Y, Wu P, Gou L, Fu S, Chen P, Lu Y, Yang L. HeLa Cell-Derived Paclitaxel-Loaded Microparticles Efficiently Inhibit the Growth of Cervical Carcinoma. Int J Nanomedicine. 2020 Aug 25;15:6409-6420.
Shao F, Lyu X, Miao K, Xie L, Wang H, Xiao H, Li J, Chen Q, Ding R, Chen P, Xing F, Zhang X, Luo GH, Zhu W, Cheng G, Lon NW, Martin SE, Wang G, Chen G, Dai Y, Deng CX. Enhanced Protein Damage Clearance Induces Broad Drug Resistance in Multitype of Cancers Revealed by an Evolution Drug-Resistant Model and Genome-Wide siRNA Screening. Advanced Science (Weinh). 2020;7(23):2001914.
Miao K, Lei JH, Valecha MV, Zhang A, Xu J, Wang L, Lyu X, Chen S, Miao Z, Zhang X, Su SM, Shao F, Rajendran BK, Bao J, Zeng J, Sun H, Chen P, Tan K, Chen Q, Wong KH, Xu X, Deng CX. NOTCH1 activation compensates BRCA1 deficiency and promotes triple-negative breast cancer formation. Nature Communications. 2020;11(1):3256.
Liu J, Zhou J, Wu M, Hu C, Yang J, Li D, Wu P, Chen Y, Chen P, Lin S, Cui Y, Fu S, Wu J. Low-Dose Total Body Irradiation Can Enhance Systemic Immune Related Response Induced by Hypo-Fractionated Radiation. Frontiers in immunology. 2019 Feb 27;10:317.
Chen P, Zhang KH, Na T, Wang L, Yin WD, Yuan BZ, Wang JZ. Using Mesenchymal Stem Cells as a Novel, High Yielding and Safe Cell Substrate for the production of Viral Vaccines. Scientific Reports. 2017;7(1):12484.
Chen P, Luo S, Wen YJ, Li YH, Li J, Wang YS, Du LC, Zhang P, Tang J, Yang DB, Hu HZ, Zhao X, Wei YQ. Low-dose Paclitaxel Improves the Therapeutic Efficacy of Recombinant Adenovirus Encoding CCL21 Chemokine against Murine Cancer. Cancer Science. 2014;105(11):1393-401.
Luo S, Chen P, Luo ZC, et al. Combination of vesicular stomatitis virus matrix protein gene therapy with low-dose cisplatin improves therapeutic efficacy against murine melonoma. Cancer Science. 2010;101(5):1219-25.
Fang F, Chen P, Wu X, Yang L, Yang X, Xi ZX, Zhou BW, Zhou XK, Qian ZY, Xiao B, Wei YQ.Therapeutic effects of recombinant human endostatin adenovirus in a mouse model of malignant pleural effusion. Journal of Cancer Research & Clinical Oncology. 2009;135(9):1149-57.
Huang AL, Wan Y, Liao DY, Hu HZ, Wei L, Wang XH, Wen YJ, Li J, Chen LJ, Kan B, Chen P, Wang YS, Chen X, Zhao X, Deng HX, Wei YQ. Suppression of human MDA-MB-435S tumor by U6 promoter-driven short hairpin RNAs targeting focal adhesion kinase. Journal of Cancer Research & Clinical Oncology. 2010 Aug;136(8):1229-42.
Li J, Wei Y, Liu K, Yuan C, Tang Y, Quan Q, Chen P, Wang W, Hu H, Yang L. Synergistic effects of FGF-2 and PDGF-BB on angiogenesis and muscle regeneration in rabbit hindlimb ischemia model. Microvascular research. 2010;80(1):10-7.
Liu L, Deng H, Wang Y, Chen P, Yang Y, Yang H, Chen X, Chen L, Zhu W, Liang S, Yang J, Qian Z, Li J, Wen Y, Kan B, Mao Y, Zhao X, Wei Y. A novel strategy for tumor therapy combining cell apoptosis and active immunity induced by caspy2, a zebrafish caspase. Journal of Cellular and Molecular Medicine. 2009;13(8B):2271-81.
Wang YS, Li D, Shi HS, Wen YJ, Yang L, Xu N, Chen XC, Chen X, Chen P, Li J, Deng HX, Wang CT, Xie G, Huang S, Mao YQ, Chen LJ, Zhao X, Wei YQ. Intratumoral expression of mature human neutrophil peptide-1 mediates antitumor immunity in mice. Clinical Cancer Resarch. 2009;15(22):6901-11.
Wen J, Fu AF, Chen LJ, Xie XJ, Yang GL, Chen XC, Wang YS, Li J, Chen P, Tang MH, Shao XM, Lu Y, Zhao X, Wei YQ. Liposomal honokiol inhibits VEGF-D- induced lymphangiogenesis and metastasis in xenograft tumor model. International Journal of Cancer. 2009;124(11):2709-18.
Chen P, Yang LL, Yang HS, Wang YS, Li G, Wu Y, Fang F, Liu K, Li J, Zhao X, Hu HZ, Wei YQ. Synergistic antitumor effect of CXCL10 with hyperthermia. Journal of Cancer Research & Clinical Oncology. 2008;134(6):679-87.
Wang Z, Jiang L, Huang C, Li Z, Chen L, Gou L, Chen P, Tong A, Tang M, Gao F, Shen J, Zhang Y, Bai J, Zhou M, Miao D, Chen Q. Comparative proteomics approach to screening of potential diagnostic and therapeutic targets for oral squamous cell carcinoma. Molecular & Cellular Proteomics. 2008;7(9):1639-50.
Tong A, Wu L, Lin Q, Lau QC, Zhao X, Li J, Chen P, Chen L, Tang H, Huang C, Wei YQ.Proteomic analysis of cellular protein alterations using a hepatitis B virus-producing cellular model. Proteomics. 2008;8(10):2012-23.
Wang YS, Wang GQ, Wen YJ, Wang L, Chen XC, Chen P, Kan B, Li J, Huang C, Lu Y, Zhou Q, Xu N, Li D, Fan LY, Yi T, Wu HB, Wei YQ. Immunity against tumor angiogenesis induced by a fusion vaccine with murine beta-defensin 2 and mFlk-1. Clinical Cancer Resarch. 2007 Nov 15;13(22 Pt 1):6779-87.