Zhenghai TANG

1. Providing an in-depth mechanistic understanding of immune checkpoints to enable the rational development of first-in-class monoclonal antibodies, bispecific antibodies, and antibody-drug conjugates.
2. Screening for novel immune checkpoints using CRISPR with specific sgRNA libraries for cancer therapy.

His research is supported by grants as PI, such as the Young Scientists Fund Scheme (Category B) (原優秀青年科學基金) and the Science and Technology Development Fund (FDCT) of Macau etc.

1. Tang Z, Zhong MC, Qian J, Galindo CC, Davidson D, Li J, Zhao Y, Hui E, Veillette A: CD47 masks pro-phagocytic ligands in cis on tumor cells to suppress anti-tumor immunity. Nature Immunology 2023, 24: 2032–2041.
2. Tang Z, Veillette A: Combining a first-in-class SLAMF7 antibody with SIRPα blockade for anti-tumor immunity. Nature Immunology 2023, 24: 1978–1979.
3. Tang Z, Veillette A: Improving treatment of solid cancers by nanoconjugate-mediated immune conversion of tumour cells. Nature Nanotechnology 2022, 17:1243-4.
4. Tang Z^#, Davidson D^#, Li R, Zhong MC, Qian J, Chen J, Veillette A: Inflammatory macrophages exploit unconventional pro-phagocytic integrins for phagocytosis and anti-tumor immunity. Cell Reports 2021, 37:110111.
5. Tang ZH, Cao WX, Guo X, Dai XY, Lu JH, Chen X, Zhu H, Lu JJ: Identification of a novel autophagic inhibitor cepharanthine to enhance the anti-cancer property of dacomitinib in non-small cell lung cancer. Cancer Letters 2018, 412:1-9.
6. Tang ZH, Lu JJ: Osimertinib resistance in non-small cell lung cancer: Mechanisms and therapeutic strategies. Cancer Letters 2018, 420:242-6.
7. Tang ZH^#, Su MX^#, Guo X, Jiang XM, Jia L, Chen X, Lu JJ: Increased Expression of IRE1alpha Associates with the Resistant Mechanism of Osimertinib (AZD9291)-resistant non-small Cell Lung Cancer HCC827/OSIR Cells. Anti-Cancer Agents in Medicinal Chemistry 2018, 18:550-5.
8. Tang ZH^#, Cao WX^#, Wang ZY, Lu JH, Liu B, Chen X, Lu JJ: Induction of reactive oxygen species-stimulated distinctive autophagy by chelerythrine in non-small cell lung cancer cells. Redox Biology 2017, 12:367-76.
9. Tang ZH, Cao WX, Su MX, Chen X, Lu JJ: Osimertinib induces autophagy and apoptosis via reactive oxygen species generation in non-small cell lung cancer cells. Toxicology and Applied Pharmacology 2017, 321:18-26.
10. Tang ZH^#, Guo X^#, Cao WX, Chen X, Lu JJ: Fangchinoline accumulates autophagosomes by inhibiting autophagic degradation and promoting TFEB nuclear translocation. RSC Advances 2017, 7:42597-605.
11. Tang ZH, Chen X, Wang ZY, Chai K, Wang YF, Xu XH, Wang XW, Lu JH, Wang YT, Chen XP, Lu JJ: Induction of C/EBP homologous protein-mediated apoptosis and autophagy by licochalcone A in non-small cell lung cancer cells. Scientific Reports 2016, 6:1-10.
12. Tang ZH^#, Jiang XM^#, Guo X, Fong CMV, Chen X, Lu JJ: Characterization of osimertinib (AZD9291)-resistant non-small cell lung cancer NCI-H1975/OSIR cell line. Oncotarget 2016, 7:81598.
13. Tang ZH, Li T, Tong YG, Chen XJ, Chen XP, Wang YT, Lu JJ: A systematic review of the anticancer properties of compounds isolated from Licorice (Gancao). Planta Medica 2015, 81:1670-87.
14. Tang ZH, Zhang LL, Li T, Lu JH, Ma DL, Leung CH, Chen XP, Jiang HL, Wang YT, Lu JJ: Glycyrrhetinic acid induces cytoprotective autophagy via the inositol-requiring enzyme 1α-c-Jun N-terminal kinase cascade in non-small cell lung cancer cells. Oncotarget 2015, 6:43911.
15. Chen XJ^#, Tang ZH^#, Li XW, Xie CX, Lu JJ, Wang YT: Chemical constituents, quality control, and bioactivity of Epimedii Folium (Yinyanghuo). American Journal of Chinese Medicine 2015, 43:783-834.
16. Tang ZH, Li T, Chang LL, Zhu H, Tong YG, Chen XP, Wang YT, Lu JJ: Glycyrrhetinic Acid triggers a protective autophagy by activation of extracellular regulated protein kinases in hepatocellular carcinoma cells. Journal of Agricultural and Food Chemistry 2014, 62:11910-6.

Other articles :

1. Li B, Lu Y, Zhong MC, Qian J, Li R, Davidson D, Tang Z, Zhu K, Argenty J, de Peredo AG, Malissen B, Roncagalli R, Veillette A: Cis interactions between CD2 and its ligands on T cells are required for T cell activation. Science Immunology 2022, 7:eabn6373.
2. Li T, Xu XH, Guo X, Yuan T, Tang ZH, Jiang XM, Xu YL, Zhang LL, Chen X, Zhu H, Shi JJ, Lu JJ: Activation of notch 3/c-MYC/CHOP axis regulates apoptosis and promotes sensitivity of lung cancer cells to mTOR inhibitor everolimus. Biochemical Pharmacology 2020, 175:113921.
3. Veillette A, Tang Z: Signaling Regulatory Protein (SIRP)alpha-CD47 Blockade Joins the Ranks of Immune Checkpoint Inhibition. Journal of Clinical Oncology 2019, 37:1012-4.
4. Cao WX, Li T, Tang ZH, Zhang LL, Wang ZY, Guo X, Su MX, Chen X, Lu JJ: MLKL mediates apoptosis via a mutual regulation with PERK/eIF2alpha pathway in response to reactive oxygen species generation. Apoptosis 2018, 23:521-31.
5. Wang YF, Tang ZH, Li T, Xu XH, Chen X, Wang Y, Wang YT, Lu JJ: Baicalein protects tert‑butyl hydroperoxide‑induced hepatotoxicity dependent of reactive oxygen species removal. Molecular Medicine Reports 2017, 16:8392-8.
6. Wang YF, Xu YL, Tang ZH, Li T, Zhang LL, Chen X, Lu JH, Leung CH, Ma DL, Qiang WA, Wang YT, Lu JJ: Baicalein Induces Beclin 1- and Extracellular Signal-Regulated Kinase-Dependent Autophagy in Ovarian Cancer Cells. American Journal of Chinese Medicine 2017, 45:123-36.
7. Wang FZ, Xing L, Tang ZH, Lu JJ, Cui PF, Qiao JB, Jiang L, Jiang HL, Zong L: Codelivery of doxorubicin and shAkt1 by poly (ethylenimine)–glycyrrhetinic acid nanoparticles to induce autophagy-mediated liver cancer combination therapy. Molecular Pharmaceutics 2016, 13:1298-307.
8. Zhang LL, Xu YL, Tang ZH, Xu XH, Chen X, Li T, Ding CY, Huang MQ, Chen XP, Wang YT, Yuan XF, Lu JJ: Effects of alisol B 23-acetate on ovarian cancer cells: G1 phase cell cycle arrest, apoptosis, migration and invasion inhibition. Phytomedicine 2016, 23:800-9.
9. Wang X, Zhou J, Chen B, Tang Z, Zhang J, Li L, Tang J: Enhanced intracellular hyperthermia efficiency by magnetic nanoparticles modified with nucleus and mitochondria targeting peptides. Journal of Nanoscience and Nanotechnology 2016, 16:6560-6.
10. Chen X, Wu QS, Meng FC, Tang ZH, Chen X, Lin LG, Chen P, Qiang WA, Wang YT, Zhang QW, Lu JJ: Chikusetsusaponin IVa methyl ester induces G1 cell cycle arrest, triggers apoptosis and inhibits migration and invasion in ovarian cancer cells. Phytomedicine 2016, 23:1555-65.
11. Zhang LL, Tian K, Tang ZH, Chen XJ, Bian ZX, Wang YT, Lu JJ: Phytochemistry and Pharmacology of Carthamus tinctorius L. American journal of Chinese medicine 2016, 44:197-226.
12. Li T, Tang ZH, Xu WS, Wu GS, Wang YF, Chang LL, Zhu H, Chen XP, Wang YT, Chen Y, Lu JJ: Platycodin D triggers autophagy through activation of extracellular signal-regulated kinase in hepatocellular carcinoma HepG2 cells. European Journal of Pharmacology 2015, 749:81-8.
13. Li T, Xu XH, Tang ZH, Wang YF, Leung CH, Ma DI, Chen XP, Wang YT, Chen Y, Lu JJ: Platycodin D induces apoptosis and triggers ERK-and JNK-mediated autophagy in human hepatocellular carcinoma BEL-7402 cells. Acta Pharmacologica Sinica 2015, 36:1503-13.
14. Wang YF, Li T, Tang ZH, Chang LL, Zhu H, Chen XP, Wang YT, Lu JJ: Baicalein triggers autophagy and inhibits the protein kinase B/mammalian target of rapamycin pathway in hepatocellular carcinoma HepG2 cells. Phytotherapy Research 2015, 29:674-9.

• Acta Pharmaceutica Sinica B
• Biomedicine & Pharmacotherapy
• Biomedical and Environmental Sciences
• Cancer Letters
• Cell Communication and Signaling
• Cell Reports
• Chinese Journal of Natural Medicines
• Frontiers in Immunology
• Heliyon
• Journal of Experimental & Clinical Cancer Research
• Molecular and Cellular Biology
• Phytomedicine
• Phytotherapy Research