Contact Information
Address(Office)E12-4008 Zhen YUAN
(Lab)E12-3017
Phone(Office)8822 4989
(Lab)8822 2736
Fax8822 2314
Emailzhenyuan@um.edu.mo

 

Education
Ph.D.Mechanical Engineering (Biomedical Direction), University of Sciences and Technology of China, Hefei, China (2002)
Positions
08/2017-presentAssociate Professor, Faculty of Health Sciences, University of Macau
08/2013-08/2017Assistant Professor, Faculty of Health Sciences, University of Macau
Research Field: Molecular Imaging and Neuroimaging.
10/2012-06/2013Clinical Assistant Professor, Department of Psychology/School of Communication, Arizona State University
Research Field: EEG-fMRI fusion
09/2007-10/2012Research Assistant Professor, Biomedical Engineering Department, University of Florida.
Research Field: Biomedical Imaging and Biomedical Optics
01/2005-09/2007Postdoctoral Research Associate, Biomedical Engineering Department, University of Florida, Gainesville, FL32611. Research Field: Biomedical Imaging and Signal Processing
03/2004-01/2005Postdoctoral Research Fellow, Department of Physics, Clemson University, SC29634
Research Field: Biomedical Optical Imaging
03/2002-03/2004Postdoctoral Research Scientist, Institute of High performance Computing, National University of Singapore, Singapore 117523. Research Field: BioMEMS and Biomaterials
Research Interests
Neurosciences and Neuroimaging

  • Neuroimaging
  • Brain Disorders and Brain Cognition
  • Hyperscanning
  • Optogenetics, Brain Intervention and Brain Modulation

Biomedical Optics and Optical Molecular Imaging

  • Diffuse Optical Tomography(DOT);
  • Functional Near Infrared Spectroscopy (fNIRS);
  • Photoacoustic Tomography/Photoacoustic Microscopy (PAT and PAM);
  • Optical Coherence Tomography(OCT);
  • Photothermal and Photodynamic Therapy;
  • Molecular Imaging and Cancer Nanomedicine;
Representative Publications
Neuroscience and Neuroimaging

  1. Zhishan Hu; Juan Zhang; Lingyan Zhang; Yu-Tao Xiang; Zhen Yuan. Linking brain activation to topological organization in the frontal lobe as a synergistic indicator to characterize the difference between various cognitive processes of executive functions. Neurophotonics, 6(2), 025008, 2019.
  2. Z Hu, J Zhang, TA Couto, S Xu, P Luan, Yuan, Zhen. Optical Mapping of Brain Activation and Connectivity in Occipitotemporal Cortex during Chinese Character Recognition. Brain Topography, 1-15, 2018.
  3. X Lin, L Sai, Yuan, Zhen. Detecting concealed information with fused electroencephalography and functional near-infrared spectroscopy. Neuroscience (06): 049-058, 2018.
  4. Liu, CH, Ma, X, Yuan, Z. Decreased resting-state activity in the precuneus is associated with depressive episodes in recurrent depression. The Journal of Clinical Psychiatry, 13(1). pp. 7-13, 2017.
  5. Zhong-Ming Zhang, Meng-Yun Wang, Xiaowei Guo, Xiaocui Miao, Ting Zhang, Dong Gao, Yuan, Zhen. Attentional avoidance of threats in obsessive compulsive disorder: An event related potential study. Behaviour Research and Therapy, 97, pp. 96-104, 2017.
  6. Z Hu, KF Lam, YT Xiang, Z Yuan. Causal Cortical Network for Arithmetic Problem-Solving Represents Brain’s Planning Rather than Reasoning. International Journal of Biological Sciences 15 (6), 1148-1160, 2019..
  7. Juan Zhang, Yaxuan Meng, Chenggang Wu, Yu-Tao Xiang, Zhen Yuan. Non-speech and Speech Pitch Perception among Cantonese-speaking Children with Autism Spectrum Disorder: an ERP Study. Neuroscience letters, 703, 205-212, 2019.
  8. HF Ieong, Z Yuan. Desynchronized Lower Alpha Rhythms Were Associated With Functional Ischemia in the Prefrontal Cortex in Heroin Patients After Protracted Abstinence: A Concurrent EEG-fNIRS Study. Biological Psychiatry 85 (10), S295-S296, 2019.
  9. HF Ieong, Yuan, Zhen. Emotion recognition and its relation to prefrontal function and network in heroin plus nicotine dependence: a pilot study. Neurophotonics 5 (2): 025011, 2018.
  10. X Lin, VLC Lei, D Li, Yuan, Zhen. Which is more costly in Chinese to English simultaneous interpreting, “pairing” or “transphrasing”? Evidence from an fNIRS neuroimaging study. Neurophotonics 5 (2): 025010, 2018.
  11. MY Wang, FM Lu, Z Hu, J Zhang, Yuan, Zhen. Optical mapping of prefrontal brain connectivity and activation during emotion anticipation.  Behavioural Brain Research (350): 122-128, 2018.
  12. Juan Zhang, Yaxuan Meng, Jinbo He, Yutao Xiang, Chenggang Wu, Shibin Wang, Zhen Yuan. McGurk Effect by Individuals with Autism Spectrum Disorder and Typically Developing Controls: A Systematic Review and Meta-analysis. Journal of Autism and Developmental Disorders:  doi.org/10.1007/s10803-018-3680-0, 2018.
  13. MY Wang, J Zhang, FM Lu, YT Xiang, Yuan, Zhen. (8/2018). Neuroticism and conscientiousness respectively positively and negatively correlated with the network characteristic path length in dorsal lateral prefrontal cortex: A resting-state fNIRS study. Brain and Behavior. https://doi.org/10.1002/brb3.1074,
  14. Zhang, ZM, Wang, MY, Miao, XC, Li, YJ, Hitchman, G, & Yuan, Z.. Individuals with high obsessive-compulsive tendencies or undermined confidence rely more on external proxies to access their internal states. Journal of Behavior Therapy and Experimental Psychiatry, 54. pp. 263-269, 2016.
  15. Liu, CH, Liu, CZ, Zhang, JH, Yuan, Z. Reduced spontaneous neuronal activity in the insular cortex and thalamus in healthy adults with insomnia symptoms. Brain Research, 8993 (6). pp. doi: 10.1016/j.brainres.2016.07.024.-doi: 10.1016/j.brainres.2016.07.024, 2016.
  16. Feng-Mei Lu, Jian-Song Zhou, Xiao-Ping Wang, Yu-Tao Xiang, Zhen Yuan*. Short- and long-range functional connectivity density alterations in adolescents with pure conduct disorder at resting-state. Neuroscience, 351, 96-107, 2017.
  17. Feng-Mei Lu, Chun-Hong Liu, Shun-Li Lu, Li-Rong Tang, Chang-Le Tie, Juan Zhan, Zhen Yuan*. Disrupted topology of frontostriatal circuits is linked to the severity of insomnia. Frontiers in Neuroscience, 11,214(2017)
  18. Zhang, ZJ, Yuan, Z. Quantitative Analysis of the Power Changes in BOLD Signals of Cortical Activity during Different Single-hand Motor Imageries Using Welch Spectrum Method. Magnetic Resonance Imaging, 32. pp. 1307-1313, 2014.
  19. Yuan, Z. Fusion of fNIRS and fMRI data: identifying when and where hemodynamic signals are changing in human brains. Front Hum Neurosci, 7. pp. 676(1)-676(9), 2013.
  20. Yuan, Z. Spatiotemporal and time-frequency analysis of functional near infrared spectroscopy brain signals using independent component analysis. Journal of Biomedical Optics, 18(10). pp. 106011(1)-106011(10), 2013.
  21. Yuan, Z. Combining independent component analysis and Granger causality to investigate brain network dynamics with fNIRS measurements. Biomedical Optics Express, 4(11). pp. 2629-2643, 2013.

 

Molecular Imaging and Cancer Nanomedicine

  1. Hao Xu, Tymish Y Ohulchanskyy, Artem Yakovliev, Roman Zinyuk, Jun Song, Liwei Liu, Junle Qu, Yuan, Zhen. Nanoliposomes Co-Encapsulating CT Imaging Contrast Agent and Photosensitizer for Enhanced, Imaging Guided Photodynamic Therapy of Cancer. THERANOSTICS, 2019, 9(5), 1323-1335, 2019.
  2. K Chang, D Gao, Y Liu, Q Qi, Yuan, Zhen. Engineering biocompatible benzodithiophene-based polymer dots with tunable absorptions as high-efficiency theranostic agents for multiscale photoacoustic imaging-guided photothermal therapy. Biomater. Sci., 2019, 7, 1486-1492.
  3. Kaiwen Chang, Yubin Liu, Dehong Hu, Qiaofang Qi, Duyang Gao, Yating Wang, Dongliang Li, Xuanjun Zhang, Hairong Zheng, Zonghai Sheng, Zhen Yuan. Highly Stable Conjugated Polymer Dots as Multifunctional Agents for Photoacoustic Imaging-Guided Photothermal Therapy. ACS Appl. Mater. Interfaces, 10 (8), pp 7012–7021, 2018.
  4. Duyang Gao, Xia Ji, Jiuling Wang, Yating Wang, Dongliang Li, Yubin Liu, Kaiwen Chang, Junle Qu, Zheng Jun, Zhen Yuan. Engineering Protein-Based Nanoplatform as Antibacterial Agents for Light Activated Dual-Modal Photothermal and Photodynamic Therapy of Infection in Both the NIR I and II Windows. J. Mater. Chem. B, 6, 732-739, 2018.
  5. Gao, DY, Sheng, ZH, Liu, YB, Hu, DR, Zhang, J, Zhang, X., Zheng, HR, & Yuan, Z.  Protein-Modified CuS Nanotriangle: A Potential Multimodal Nanoplatform for in vivo Tumor Photoacoustic/Magnetic Resonance Dual-Modal Imaging. Advanced Healthcare Materials, 6(1),1601094 adhm.201601094, 2017.
  6. D Gao, P Zhang, Y Liu, Z Sheng, H Chen, Yuan, Zhen*. Protein-modified conjugated polymer nanoparticles with strong near-infrared absorption: a novel nanoplatform to design multifunctional nanoprobes for dual-modal photoacoustic and fluorescence imaging. Nanoscale, 10, 19742-19748, 2018.
  7. Da Zhang, Hao Xu, Xiaolong Zhang, Yubin Liu, Ming Wu, Juan Li, Huanghao Yang, Gang Liu, Xiaolong Liu, Jingfeng Liu, Zhen Yuan. Self-Quenched Metal–Organic Particles as Dual-Mode Therapeutic Agents for Photoacoustic Imaging-Guided Second Near-Infrared Window Photochemotherapy. ACS applied materials & interfaces 10(30), 25203-25212, 2018.
  8. Zhang, J, Chen, HB, ZHou, T, Wang, LM, Gao, DY, Zhang, X., Liu, YB, Wu, CF, & Yuan, Z. A PIID-DTBT based semiconducting polymer dot with broad and strong optical absorption in the visible-light region as a highly-effective contrast agent for multiscale and multi-spectral photoacoustic imaging. Nano Research, 12274. pp. 1-14, 2016.
  9. Duyang Gao, Yuan, Zhen. Controllable synthesis of biocompatible triangular quantum dots with near-infrared emitting and their application for in vivo lymph node imaging. Nanomedicine: Nanotechnology, Biology and Medicine. 14(5):1881, 2018.
  10. Lipeng Zhu, Ping Li, Duyang Gao, Jie Liu, Yubin Liu, Chen Sun, Mengze Xu, Zonghai Sheng, Ruibing Wang, Zhen Yuan, Lintao Cai, Yifan Ma, Qi Zhao. pH-sensitive loaded retinal/indocyanine green micelles as a “all-in-one” theranostic agent for multi-modal imaging in vivo guided cellular senescence-photothermal synergistic therapy. Chem. Commun., 2019, DOI: 10.1039/C9CC02567G.
  11. B Zhang, F Wang, H Zhou, D Gao, Z Yuan, C Wu, X Zhang. Polymer Dots Compartmentalized in Liposomes as a Photocatalyst for In Situ Hydrogen Therapy. Angewandte Chemie International Edition 58 (9), 2744-2748, 2019.
  12. Libo Zhou, Ying Jing, Yubin Liu, Zhihe Liu, Duyang Gao, Haobin Chen, Weiye Song, Tao Wang, Xiaofeng Fang, Weiping Qin, Zhen Yuan, Sheng Dai, Zhen-An Qiao, Changfeng Wu. Mesoporous Carbon Nanospheres as a Multifunctional Carrier for Cancer. Theranostics. 2018; 8(3): 663–675.
  13. Kai Sun, Yingkun Yang, Hua Zhou, Shengyan Yin, Weiping Qin, Jiangbo Yu, Daniel T Chiu, Zhen Yuan, Xuanjun Zhang, Changfeng Wu. Ultrabright Polymer-Dot Transducer Enabled Wireless Glucose Monitoring via a Smartphone. ACS Nano 12 (6): 5176–5184, 2018.
  14. Kaiwen Chang, Zhihe Liu, Xiaofeng Fang, Haobin Chen, Xiaoju Men, Ye Yuan, Kai Sun, Xuanjun Zhang, Zhen Yuan, Changfeng Wu. Enhanced Phototherapy by Nanoparticle-Enzyme via Generation and Photolysis of Hydrogen Peroxide. Nano Letters, 17 (7), pp 4323–4329, 2017.
  15. Zhaoyang Ding, Jingyun Tan, Gang Feng, Zhen Yuan, Changfeng Wu, Xuanjun Zhang. Nanoscale metal-organic frameworks coated with poly (vinyl alcohol) for ratiometric peroxynitrite sensing through FRET. Chemical Science, 8, pp. 5101-5106, 2017.
  16. Gao, DY, Yuan, Zhen. Photoacoustic-Based Multimodal Nanoprobes: from Constructing to Biological Applications. International Journal of Biological Sciences, 13(4), 401-412, 2017.
  17. Chen D, Li Q, Meng Z, Guo L, Tang Y, Liu Z, Yin S, Qin W, Yuan Z, Zhang X, Wu C. Bright Polymer Dots Tracking Stem Cell Engraftment and Migration to Injured Mouse Liver. Theranostics, 7(7), pp.1820–1834, 2017.
  18. Haobin Chen, Jian Zhang, Kaiwen Chang, Xiaoju Men, Xiaofeng Fang, Libo Zhou, Dongliang Li, Duyang Gao, Shengyan Yin, Xuanjun Zhang, Zhen Yuan, Changfeng Wu. Highly absorbing multispectral near-infrared polymer nanoparticles from one conjugated backbone for photoacoustic imaging and photothermal therapy. Biomaterials 144, 42-5, 20172.
  19. Zhang, J, Liu, J, Wang, LM, Li, Zy, & Yuan, Z. Retroreflective-type Janus microspheres as a novel contrast agent for enhanced optical coherence tomography. Journal of Biophotonics, jbio.20160. pp. 1-9, 2016.
  20. Sun, K., Tang, Y., Li, Q., Yin, S., Qin, W., Yu, J., Chiu, D., Liu, Y., Yuan, Z., Zhang, X., & Wu, C. (16/06/2016). In vivo dynamic monitoring of small molecules with implantable polymer-dot transducer. ACS Nano, 10(1). pp. 1-16.
  21. Liu, ZH, Sun, ZZ, Di, WH, Qin, WP, Yuan, Z., & Wu, CF. Brightness calibrates particle size in single particle fluorescence imaging. Optics Letters, 2015(2). pp. 231829(1)-2318299(3), 2015.
  22. Zhang, YL, Liu, XH, Lang, YB, Yuan, Z., Zhao, D, Qin, GS, & Qin, WP. Synthesis of ultra-small BaLuF 5: Yb 3+, Er 3+@ BaLuF 5: Yb 3+ active-core–active-shell.  Journal of Materials Chemistry, 2015(3). pp. 2045-2053.
  23. Zhang, KZ, Song, WY, He, GH, Yuan, Z., & Qin, WP. Five-photon UV upconversion emissions of Er3+. Optics Express, 23(6). pp. 7653-7658, 2015.

 

Biomedical Optics and Optical Imaging

  1. Xiong Kedi,, Wei Wang, Ting, Guo, Zhen Yuan, Sihua Yang. Shape-adapting panoramic photoacoustic endomicroscopy, Optics Letters, 2019, https://www.osapublishing.org/DirectPDFAccess/7D6253E9-B64C-569A-9E6518977695128E_ads363592.pdf?da=1&adsid=363592&journal=3&seq=0&mobile=no.
  2. Yubin Liu  Duyang Gao  Mengze Xu  Zhen Yuan. Multispectral photoacoustic imaging of cancer with broadband CuS nanoparticles covering both near‐infrared I and II biological windows. Journal of Biophotonics, 2019, https://doi.org/10.1002/jbio.201800237.
  3. Y Liu, L Fu, M Xu, J Zheng, Yuan, Zhen. Dual-Modal In Vivo Fluorescence/Photoacoustic Microscopy Imaging of Inflammation Induced by GFP-Expressing Bacteria(2019). Sensors 19 (2), 238-243, 2019.
  4. Liu, YB, & Yuan, Z. Two schemes for quantitative photoacoustic tomography based on Monte Carlo simulation. Medical Physics, 43(7). pp. 3987-3997, 2016.
  5. Liu, YB, & Yuan, Z. (01/07/2016). Multi-spectral photoacoustic elasticity tomography. Biomedical Optics Express, 7(9). pp. 3323-3334.
  6. Y Zhao, S Yang, Y Wang, Z Yuan, J Qu, L Liu (2018). In vivo blood viscosity characterization based on frequency-resolved photoacoustic measurement. Applied Physics Letters 113 (14), 143703.
  7. Jian Zhang, Sio Hang Pun, Yuanyu Yu, Duyang Gao, Jiujiang Wang, Peng Un Mak, Kin Fong Lei, Ching-Hsiang Cheng, Yuan, Zhen. Development of a multi-band photoacoustic tomography imaging system based on a capacitive micromachined ultrasonic transducer array. Applied Optics, 56 (24), pp. 4012-4018, 2017.
  8. Yubin Liu, Lingyan Zhang, Sushu Li, Xinai Han, Zhen Yuan*. Imaging molecular signatures for clinical detection of scleroderma in the hand by multispectral photoacoustic elastic tomography. Journal of Biophotonics. DOI: 10.1002/jbio.201700267, 2018.
  9. Zhang, J., Ge, W., & Yuan, Z. In vivo three-dimensional characterization of the adult zebrafish brain at video rate with a 1325 nm long range spectral-domain optical coherence tomography system. Biomedical Optics Express, 6. pp. 3932-3940, 2015.
  10. Yuan, Z, Li, XQ, & Xi, L. Listening to light scattering in turbid media: quantitative optical scattering imaging using photoacoustic measurements with one-wavelength illumination. J. Opt., 16. pp. 065301(1)-065301(8), 2014.
  11. Yuan, Z, Zhang, J, Wang, XD, & Li, CQ. A systematic investigation of reflectance diffuse optical tomography using nonlinear reconstruction methods and continuous wave measurements. Biomedical Optics Express, 5(9). pp. 3012-3022, 2014.
  12. Yuan, Z., Wang, Q, & Jiang, HB. Simultaneous reconstruction of acoustic and optical properties of heterogeneous media by quantitative photoacoustic tomography. Optics Express, 14(15). pp. 6749-6754, 2006.
  13. Yuan, Z., Zhang, QZ, Sobel, E, & Jiang, HB (21/05/2007). Three-dimensional diffuse optical tomography of osteoarthritis: initial results in the finger joints. Journal of Biomedical Optics, 12(3). pp. 034001-1-034001-11.
  14. Yuan, Z., & Jiang, HB (18/12/2007). Reconstruction of optical absorption coefficient maps of heterogeneous media by photoacoustic tomography coupled with diffusion equation based regularized Newton Method . Optics Express, 15(26). pp. 18076-18081.
  15. Zhang, QZ, Yin, L, Tan, YY, Yuan, Z., & Jiang, HB (22/01/2008). Quantitative bioluminescence tomography guided by diffuse optical tomography. OPTICS EXPRESS, 16(3). pp. 1481-1486.
  16. Zhang, QZ, Liu, Z, Carney, PR, Yuan, Z., Chen, HX, Noper, SR, & Jiang, Hb (01/02/2008). Non-invasive imaging of epileptic seizures in vivo using photoacoustic tomography. Physics in Medicine and Biology, 53(7). pp. 1921-1931.
  17.  Yuan, Z., Zhang, QZ, Sobel, ES, & Jiang, HB (01/07/2008). Tomographic x-ray–guided three-dimensional diffuse optical tomography of osteoarthritis in the finger joints. Journal of Biomedical Optics, 13(4). pp. 044006-1-044006-10.
  18. Yuan, Z., Hu, XH, & Jiang, HB (29/10/2008). A higher order diffusion model for three-dimensional photon migration and image reconstruction in optical tomography. Phys. Med. Biol., 54. pp. 67-90.
  19. Yuan, Z., & Jiang, HB (16/11/2008). Three-dimensional finite-element-based photoacoustic tomography: Reconstruction algorithm and simulations. Medical Physics, 34(2). pp. 538-546.
  20. Yuan, Z., & Jiang, HB (01/06/2009). Simultaneous recovery of tissue physiological and acoustic properties and the criteria for wavelength selection in multispectral photoacoustic tomography. Optics Letters, 34(11). pp. 1714-1716.
  21. Yuan, Z., & Jiang, HB (01/08/2009). Quantitative photoacoustic tomography. Phil. Trans. R. Soc. A, 367. pp. 3043-3054.
  22. Yuan, Z., Zhang, QZ, Sobel, E, & Jiang, HB (07/10/2009). Comparison of diffusion approximation and higher order diffusion equations for optical tomography of osteoarthritis. Journal of Biomedical Optics, 14(5). pp. 054013-1-054013-7.
  23. Yuan, Z., Zhang, QZ, Sobel, E, & Jiang, HB (18/06/2010). Image-guided optical spectroscopy in diagnosis of osteoarthritis: a clinical study. Biomedical Optics Express, 1(1). pp. 74-86.
  24.  Yuan, Z., Zhang, QZ, Sobel, E, & Jiang, HB (02/07/2010). High-resolution x-ray guided three-dimensional diffuse optical tomography of joint tissues in hand osteoarthritis: Morphological and functional assessments. Medical Physics, 37(8). pp. 4343-4354.
  25. Yuan, Z., & Jiang, HB (11/2012). A calibration-free, one-step method for quantitative photoacoustic tomography. Medical Physics, 39(11). pp. 6895-6899.
  26. Yuan, Z., Wu, CF, Zhao, HZ, & Jiang, HB (15/11/2005). Imaging of small nanoparticle-containing objects by finite-element-based photoacoustic tomography. Optics Letters, 30(22). pp. 3054-3056.
  27. Jiang, HB, Yuan, Z., & Gu, XJ (01/04/2006). Spatially varying optical and acoustic property reconstruction using finite-element-based photoacoustic tomography. Journal of the Optical Society of America A, 23(4). pp. 878-888.
  28. Yuan, Z., Zhao, HZ, Wu, CF, Zhang, QZ, & Jiang, HB (01/05/2006). Finite-element-based photoacoustic tomography: phantom and chicken bone experiments. Applied Optics, 45(13). pp. 3177-3183.
  29. Yuan, Z., & Jiang, HB (05/06/2006). Quantitative photoacoustic tomography: Recovery of optical absorption coefficient maps of heterogeneous media. Applied Physics Letters, 88. pp. 231101-1-231101-3.
Full publications list

 

Research Grants
2018-2021Photoacoustic Molecular Imaging and Functional Neuroimaging Guided Photodynamic Therapy of Brain Glioma MOP 1,800,000→ FDCT → 澳門科學技術發展基金研究資助
2019-2022Development of quantitative multispectral photoacoustic elastic tomography for clinical detection of early-stage scleroderma MOP 900,000→ UM MYRG → 澳門大學多年度研究資助
2016-2019Structural and functional in vivo imaging of the bone-implant systems by multiscale photoacoustic tomography-使用多尺度光聲斷層成像實現骨- 植入物系統的活體結構和功能成像 MOP 1,310,000→ UM MYRG → 澳門大學多年度研究資助
2016-2019Using fused EEG and fNIRS to Study the Efficacy of Physical Therapy on Cerebral Palsy -使用融合的腦電和近紅外光譜成像研究運動療法治療腦癱的效果 MOP 2,200,000 → FDCT → 澳門科學技術發展基金研究資助
2015-2018Monitoring Responses to Neoadjuvant Chemotherapy in Breast Cancer Using Quantitative Photoacoustic Spectroscopy Imaging-使用定量的光声 譜成像監測乳腺癌對新輔助化療的反應 MOP 2,000,000→ UM MYRG → 澳門大學多年度研究資助
2015-2018Development of Functional Multimodal Optical Imaging Techniques for Clinical Screening of Breast Cancer -基於乳腺癌臨床篩選的多功能光學成像技術的研究MOP 1,780,000 → FDCT → 澳門科學技術發展基金研究資助
2014-2017Photoacoustic Imaging of Binding Rate of Nanoparticles in Cancer Nanomedicine – 光聲成像癌症納米探針的結合率 MOP 500,000 → UM MYRG → 澳門大學多年度研究資助
2015-2018Development of Functional Multimodal Optical Imaging Techniques for Clinical Screening of Breast Cancer -基於乳腺癌臨床篩選的多功能光學成像技術的研究MOP 600,000 → UM MRG →澳門大學多年度研究資助
2013-2014Identifying the Cortical Network Dynamics of Gambling Disorders in the Human Brains Using fNIRS Measurements-使用近紅外光譜測量識別人腦賭癮的神經網絡動力MOP 100,000 → UM SRG → 澳門大學新職員啟動研究資助
Patents
  • Hybrid Photoacoustic Tomography (PAT) and Diffuse Optical Tomography (DOT): Methods and Algorithms, International Application No. PCT/US2008/055894.
  • METHOD AND APPARATUS FOR TOMOGRAPHIC IMAGING OF ABSOLUTE OPTICAL ABSORPTION COEFFICIENT IN TURBID MEDIA USING COMBINED PHOTOACOUSTIC AND DIFFUSING LIGHT MEASUREMENTS (WO/2009/011934)
Awards
  • 2016年中國光學重大成果獎
  • 2017 FHS Best Teacher Award in Research
Professional Activities
Editorial Board Members:

  • Associate Editor of BMC Medical Imaging
  • Associate Editor of Frontiers in Human Neuroscience
  • Editorial Member of Quantitative Imaging in Medicine and Surgery
  • Special issue Editor for Biomedical Research International
  • Special issue Editor for Journal of Innovative Optical Health Sciences
  • Special issue Editor for Frontiers in Human Neuroscience
  • Special issue Editor for Biomed Research International
  • Guess Associate Editor of Medical Physics

Society Membership:

  • Senior Member of SPIE
  • Senior Member of OSA
  • Senior Member of China Biomedical Engineering Society
  • Senior Member of China Biomedical Optics Society
  • Committee Members of China Biomedical Engineering Society
Others
Teaching Interests

  • Biomedical Optics
  • Neuroimaging
  • Introduction to Neurosciences
  • Introduction to Molecular Imaging; Optical Molecular Imaging
  • Introduction to Cognitive Neuroscience
  • Cellular and Molecular Neurobiology
  • Computational Neuroscience/Neuroengineering
  • Systems and Integrative Neuroscience
  • Philosophy of Mind
  • Neurohumanities, Arts and Society
  • Clinical Neuroscience
  • Cellular and Molecular Neuroscience