Contact Information
Address (Office) E12-4008  Zhen YUAN
(Lab) E12-3017
Phone (Office) 8822 4989
(Lab) 8822 2736
Fax 8822 2314
Ph.D. Mechanical Engineering (Biomedical Direction), University of Sciences and Technology of China, Hefei, China (2002)
B.E. Mechanical and Electrical Engineering, Henan University of Sciences and Technology, Luoyang, China (1997)
08/2017-present Associate Professor, Faculty of Health Sciences, University of Macau
08/2013-08/2017 Assistant Professor, Faculty of Health Sciences, University of Macau
Research Field: Molecular Imaging and Neuroimaging.
10/2012-06/2013 Clinical Assistant Professor, Department of Psychology/School of Communication, Arizona State University
Research Field: EEG-fMRI fusion
09/2007-10/2012 Research Assistant Professor, Biomedical Engineering Department, University of Florida.
Research Field: Biomedical Imaging and Biomedical Optics
01/2005-09/2007 Postdoctoral Research Associate, Biomedical Engineering Department, University of Florida, Gainesville, FL32611. Research Field: Biomedical Imaging and Signal Processing
03/2004-01/2005 Postdoctoral Research Fellow, Department of Physics, Clemson University, SC29634
Research Field: Biomedical Optical Imaging
03/2002-03/2004 Postdoctoral Research Scientist, Institute of High performance Computing, National University of Singapore, Singapore 117523. Research Field: BioMEMS and Biomaterials
Research Interests
Neurosciences and Neuroimaging

  • Neurological Disorders in Neural Plasticity and Neural Rehabilitation;
  • Psychiatric Disorders in Addiction, Autism, Depression, Conduct Disorders, Sleep Disorders, Cerebral Palsy, and Down Syndrome;
  • Cognitive Neurosciences in Deception, Attention and Working Memory, Language and Translation, Executive Functions, Emotions, Motor, Math and Calculation, and Creativity;
  • Fused Functional Multimodal Imaging and Brain Network Analysis;
  • EEG, fMRI and fNIRS Technical Developments in Neural Networks and Neural Signal processing;
  • Communication and Brain-to Brain Interaction.

Biomedical Optics and Optical Molecular Imaging

  • Diffuse Optical Tomography(DOT);
  • Functional Near Infrared Spectroscopy (fNIRS);
  • Photoacoustic Tomography/Photoacoustic Microscopy (PAT and PAM);
  • Optical Coherence Tomography(OCT);
  • Photothermal and Photodynamic Therapy/Imaging;
  • Molecular Imaging and Cancer Nanomedicine;
  • Super Resolution Microscopy and Fluorescent Imaging.
Representative Publications
  1. Z Hu, J Zhang, TA Couto, S Xu, P Luan, Yuan, Zhen* (2018). Optical Mapping of Brain Activation and Connectivity in Occipitotemporal Cortex During Chinese Character Recognition. Brain Topography, 1-15.
  2. X Lin, L Sai, Yuan, Zhen* (2018). Detecting concealed information with fused electroencephalography and functional near-infrared spectroscopy. Neuroscience (06): 049-058.
  3. HF Ieong, Yuan, Zhen*. Emotion recognition and its relation to prefrontal function and network in heroin plus nicotine dependence: a pilot study (2018). Neurophotonics 5 (2): 025011.
  4. X Lin, VLC Lei, D Li, Yuan, Zhen* (2018). Which is more costly in Chinese to English simultaneous interpreting,“pairing” or “transphrasing”? Evidence from an fNIRS neuroimaging study. Neurophotonics 5 (2): 025010.
  5. MY Wang, FM Lu, Z Hu, J Zhang, Yuan, Zhen* (2018). Optical mapping of prefrontal brain connectivity and activation during emotion anticipation.  Behavioural Brain Research (350): 122-128.
  6. HF Ieong, Yuan, Zhen* (2018). Emotion Recognition and its Relation to Prefrontal Function and Network in Heroin Plus Nicotine Dependence: A Pilot and Translational Study. Biological Psychiatry 83 (9): S449-S450.
  7. Liu, CH, Ma, X, Yuan, Z.*, Song, RP, Jing, B, Lu, HY, Tang, LR, Fan, J, Walter, M, Liu, CZ, Wang, LH, & Wang, CY (01/02/2017). Decreased resting-state activity in the precuneus is associated with depressive episodes in recurrent depression. The Journal of Clinical Psychiatry, 13(1). pp. 7-13.
  8. Y He, MY Wang, D Li, Yuan, Zhen* (2017). Optical mapping of brain activation during the English to Chinese and Chinese to English sight translation. Biomedical Optics Express 8 (12), 5399-5411
  9. Zhong-Ming Zhang, Meng-Yun Wang, Xiaowei Guo, Xiaocui Miao, Ting Zhang, Dong Gao, Yuan, Zhen* (8/2017). Attentional avoidance of threats in obsessive compulsive disorder: An event related potential study. Behaviour Research and Therapy, 97, pp. 96-104.
  10. Hada Ieong, Zhen Yuan* (7/2017). Resting-state neuroimaging and neuropsychological findings in opiate use disorder during abstinence: a review. Front. Hum. Neurosci., 11, 169.
  11. Feng-Mei Lu, Jian-Song Zhou, Xiao-Ping Wang, Yu-Tao Xiang, Zhen Yuan* (2017). Short- and long-range functional connectivity density alterations in adolescents with pure conduct disorder at resting-state. Neurosciences, 351, 96-107.
  12. Liu, CH, Liu, CZ, Zhang, JH, Yuan, Z.*, Tang, LR, Tie, CL, Fan, J, & Liu, QQ (16/07/2016). Reduced spontaneous neuronal activity in the insular cortex and thalamus in healthy adults with insomnia symptoms. Brain Research, 8993 (6). pp. doi: 10.1016/j.brainres.2016.07.024.-doi: 10.1016/j.brainres.2016.07.024.
  13. Yuan, Z.* (01/10/2013). Spatiotemporal and time-frequency analysis of functional near infrared spectroscopy brain signals using independent component analysis. Journal of Biomedical Optics, 18(10). pp. 106011(1)-106011(10).
  14. Zhang, ZM, Wang, MY, Miao, XC, Li, YJ, Hitchman, G, & Yuan, Z.* (14/10/2016). Individuals with high obsessive-compulsive tendencies or undermined confidence rely more on external proxies to access their internal states. Journal of Behavior Therapy and Experimental Psychiatry, 54. pp. 263-269.
  15. Zhang, J, Yuan, Z.*, Huang, J, Yang, Q, & Chen, HF (25/08/2014). Quantitative Analysis of the Power Changes in BOLD Signals of Cortical Activity during Different Single-hand Motor Imageries Using Welch Spectrum Method. Magnetic Resonance Imaging, 32. pp. 1307-1313.
  16. Yuan, Z.* (31/08/2013). Fusion of fNIRS and fMRI data: identifying when and where hemodynamic signals are changing in human brains. Front Hum Neurosci, 7. pp. 676(1)-676(9).
  17. Feng-Mei Lu, Chun-Hong Liu, Shun-Li Lu, Li-Rong Tang, Chang-Le Tie, Juan Zhan, Zhen Yuan*. Disrupted topology of frontostriatal circuits is linked to the severity of insomnia. Frontiers in Neurosciences, 11,214(2017)
  18. Yuan, Z.* (01/11/2013). Combining independent component analysis and Granger causality to investigate brain network dynamics with fNIRS measurements. Biomedical Optics Express, 4(11). pp. 2629-2643.
  19. Xiaohong Lin, Shiyang Xu, Hada Fong-Ha Ieong, and Zhen Yuan* (9/2017). Optical mapping of prefrontal activity in pathological gamblers. Applied Optics, 56(21), pp.5948-5953.
  20. Kaiwen Chang, Yubin Liu, Dehong Hu, Qiaofang Qi, Duyang Gao, Yating Wang, Dongliang Li, Xuanjun Zhang, Hairong Zheng, Zonghai Sheng, Zhen Yuan* (2018). Highly Stable Conjugated Polymer Dots as Multifunctional Agents for Photoacoustic Imaging-Guided Photothermal Therapy. ACS Appl. Mater. Interfaces, 10 (8), pp 7012–7021.
  21. Duyang Gao, Xia Ji, Jiuling Wang, Yating Wang, Dongliang Li, Yubin Liu, Kaiwen Chang, Junle Qu, Zheng Jun, Zhen Yuan* (2018). Engineering Protein-Based Nanoplatform as Antibacterial Agents for Light Activated Dual-Modal Photothermal and Photodynamic Therapy of Infection in Both the NIR I and II Windows. J. Mater. Chem. B, 6, 732-739.
  22. Gao, DY, Sheng, ZH, Liu, YB, Hu, DR, Zhang, J, Zhang, X., Zheng, HR, & Yuan, Z.*, (01/01/2017) Protein-Modified CuS Nanotriangle: A Potential Multimodal Nanoplatform for in vivo Tumor Photoacoustic/Magnetic Resonance Dual-Modal Imaging. Advanced Healthcare Materials, 6(1),1601094 adhm.201601094.
  23. Zhang, J, Chen, HB, ZHou, T, Wang, LM, Gao, DY, Zhang, X., Liu, YB, Wu, CF, & Yuan, Z.* (15/09/2016). A PIID-DTBT based semiconducting polymer dot with broad and strong optical absorption in the visible-light region as a highly-effective contrast agent for multiscale and multi-spectral photoacoustic imaging. Nano Research, 12274. pp. 1-14.
  24. Zhang, J, Liu, J, Wang, LM, Li, Zy, & Yuan, Z.* (23/05/2016). Retroreflective-type Janus microspheres as a novel contrast agent for enhanced optical coherence tomography. Journal of Biophotonics, jbio.20160. pp. 1-9.
  25. Yubin Liu, Lingyan Zhang, Sushu Li, Xinai Han, Zhen Yuan* (2018). Imaging molecular signatures for clinical detection of scleroderma in the hand by multispectral photoacoustic elastic tomography. Journal of Biophotonics. DOI: 10.1002/jbio.201700267.
  26. Liu, YB, & Yuan, Z.* (01/07/2016). Two schemes for quantitative photoacoustic tomography based on Monte Carlo simulation. Medical Physics, 43(7). pp. 3987-3997.
  27. Liu, YB, & Yuan, Z.* (01/07/2016). Multi-spectral photoacoustic elasticity tomography. Biomedical Optics Express, 7(9). pp. 3323-3334.
  28. Zhang, J., Ge, W., & Yuan, Z.* (11/09/2015). In vivo three-dimensional characterization of the adult zebrafish brain at video rate with a 1325 nm long range spectral-domain optical coherence tomography system. Biomedical Optics Express, 6. pp. 3932-3940.
  29. Duyang Gao, Yubin Liu, Yating Wang, Zhen Yuan* (2018).Protein-modified ultra-small gold clusters for dual-modal in vivo fluorescence/photoacoustic imaging. Quantitative Imaging in Medicine and Surgery, 8(3): 326–332.
  30. Jian Zhang, Sio Hang Pun, Yuanyu Yu, Duyang Gao, Jiujiang Wang, Peng Un Mak, Kin Fong Lei, Ching-Hsiang Cheng, Yuan, Zhen* (5/2017). Development of a multi-band photoacoustic tomography imaging system based on a capacitive micromachined ultrasonic transducer array. Applied Optics, 56 (24), pp. 4012-4018.
Full publications list
Research Grants
2014-2018 MYRG, Photoacoustic Imaging of Binding Rate of Nanoparticles in Cancer Nanomedicine , MOP 500,000(PI)
2013-2014 Start-up Research Grant (SRG), Using fNIRS to identify the brain network dynamics of gambling disorders, MOP 100,000 (PI)
2012-2017 Defense Advanced Research Projects Agency (DARPA) Grant, Social Network in Narrative Mapping using fused fMRI-EEG, US$6,000,000 (Key Member)
2010-2014 National Institute of Health(NIH) R01Grant, Diffuse Optical Imaging of Epilepsy, US$ 1,400,000 (Investigator)
2009-2013 Department of Defense (DOD) Grant, Photoacoustic imaging of Epilepsy, US$2,500,000 (Key Member)
2004-2009 NIH R01 Grant, Diffuse Optical Imaging of Osteoarthritis, US$1,700,000 (Key Member)
2004-2008 NIH R01 Grant, Diffuse optical imaging of breast cancer, 1,400,000US$ (Key Member)
  • Hybrid Photoacoustic Tomography (PAT) and Diffuse Optical Tomography (DOT): Methods and Algorithms, International Application No. PCT/US2008/055894.
  • “Lixue Pandeng” Scholarship of Chinese Academy of Sciences
  • Postdoctoral Fellowship of ASTAR (Singapore)
  • University of Florida: High performance Computing Fellowship
  • 2008, 2009, 2010 &2011 “Who is Who in America”
  • 2009 ,2010,2012  &2011  “Who is Who in the World”
  • 2010,2011 “Who is Who in Medicine”
  • 2011 “Who is Who in Science and Engineering
Professional Activities
Editorial Board Members:

  • Editorial board member of Journal of Biosensors and Bioelectronics
  • Editorial board member of International Journal of Biomedical Engineering
  • Guess Associate Editor of Medical Physics
  • Guess Associate Editor of Applied Optics

Society Membership:

  • Senior Member of SPIE
  • Senior Member of OSA
  • Member of IEEE

Reviewers of Journals:

  • IEEE Transactions on Biomedical Engineering
  • IEEE Transactions on Biomedical Imaging
  • NeuroImage
  • Journal of Neural Methods
  • Nano Letters
  • Journal of Biomedical Sciences
  • Applied Optics
  • Optics Letter
  • Optics Express
  • JOSA A
  • Medical Physics
  • Physics in Medicine & Biology
  • Arthritis & Rheumatism
  • Biomedical Optics Express
  • Journal of Biomedical Optics
  • Journal of X-ray Science & Technology

Conference Organizing Committee Members:

  • ICBEB 2013, 2014
  • BME-2015
  • USA NSF Workshop of Neurosciences
Teaching Interests

  • Biomedical Optics; Neuroimaging and Neural Signal Processing
  • Biomedical Imaging and Signal Processing; Introduction to Neurosciences
  • Introduction to Molecular Imaging; Optical Molecular Imaging
  • High Performance Numerical Methods; High Performance Computing
  • Finite Element Methods; Biostatistics Methods
  • Biomedical Instrumentations; Neuroinformatics
  • Introduction to software tools in neurosciences

Teaching Experiences

  • Spring 2007-2012   Graduate course BME, titled “Advanced Mathematics and High Performance Numerical Methods” offered through the Department of Biomedical Engineering at University of Florida
  • Spring 2007-2011,  “Biomedical Imaging,” Graduate course in the Department of Biomedical Engineering at University of Florida