2020-12-15T18:38:47+08:002020-12-15|Publish|
  1. Li, S., Peng, T., Silva, M., Liu, L., Zhou, W. and Zheng, W. (2020) Artemether Confers Neuroprotection on Cerebral Ischemic Injury through Stimulation of the Erk1/2-P90rsk-CREB Signaling Pathway. Redox biology (Minor revision)
  2. Chaojun Han, Pengju Yan, Tao He, Junjie Cheng, Wenhua Zheng, Long-Tai Zheng, Xuechu Zhen. (2020) PHLDA1 promotes microglia-mediated neuroinflammation via regulating K63-linked ubiquitination of TRAF6.Brain Behav Immun 88:640-653
  3. Zhou, YiFan ; Wang, Jingqi ; Chang, Yanyu ; Li, Rui ; Sun, Xiaobo ; Peng, Lisheng ; Zheng, WenHua ; Qiu, Wei . (2020) Caffeic Acid Phenethyl Ester Protects against Experimental Autoimmune Encephalomyelitis by Regulating T Cell Activities. Oxid Med Cell Longev
  4. Yan, Fengxia ; Liao, Rifang ; Silva, Marta ; Li, Shuai ; Jiang, Yizhou ; Peng, Tangming ; Lazarovici, Philip ; Zheng, Wenhua. (2020) Pristimerin-induced uveal melanoma cell death via inhibiting PI3K/Akt/FoxO3a signalling pathway. Journal of cellular and molecular medicine 24(11),6208-6219
  5. Yan, Fengxia ; Wang, Rikang ; Li, Shuai ; Zhao, Xia ; Jiang, Yizhou ; Liu, Linlin ; Fang, Jiankang ; Zhen, Xuechu ; Lazarovici, Philip ; Zheng, Wenhua. (2020) FoxO3a suppresses neuropeptide W expression in neuronal cells and in rat hypothalamus and its implication in hypothalamic-pituitary-adrenal (HPA) axis. International journal of biological sciences 16(15), 2775-2787
  6. Zhao, X., Han, C., Zeng, Z. W., Liu, L. L., Wang, H. T., Xu, J. P., Feng, Z. P., Little, P. J., Quirion, R., and Zheng, W. (2020) Glutamate Attenuates the Survival Property of IGFR through NR2B Containing N-Methyl-D-Aspartate Receptors in Cortical Neurons. Oxid Med Cell Longev
  7. Zhao, X., Liu, L. L., Jiang, Y. Z., Silva, M., Zhen, X. C., and Zheng, W. (2020) Protective Effect of Metformin against Hydrogen Peroxide-Induced Oxidative Damage in Human Retinal Pigment Epithelial (RPE) Cells by Enhancing Autophagy through Activation of Ampk Pathway. Oxid Med Cell Longev
  8. Liu, L. L., Zhao, X., Silva, M., Li, S., Xing, X. G., and Zheng, W. (2020) Artemisinin Protects Motoneurons against Axotomy-Induced Apoptosis through Activation of the PKA-Akt Signaling Pathway and Promotes Neural Stem/Progenitor Cells Differentiation into NeuN(+) Neurons. Pharmacol Res 159
  9. Farhan, M.#, Silva, M.#, Li, S.#, Yan, F. X., Fang, J. K., Peng, T. M., Hu, J., Tsao, M. S., Little, P., and Zheng, W. (2020) The Role of FOXOs and Autophagy in Cancer and Metastasis-Implications in Therapeutic Development. Med Res Rev 40(6), 2089-2113
  10. Zhao, X., Li, S., Gaur, U., and Zheng, W. (2020) Artemisinin Improved Neuronal Functions in Alzheimer’s Disease Animal Model 3xtg Mice and Neuronal Cells via Stimulating the ERK/CREB Signaling Pathway. Aging Dis 11 (4), 801-819
  11. Farhan M, Silva M, Xingan X, Huang Y, Zheng W. (2020) Role of FOXO Transcription Factors in Cancer Metabolism and Angiogenesis. Cells 9(7)
  12. Fang, J. K., Zhao, X., Li, S. A., Xing, X. G., Wang, H. T., Lazarovici, P., and Zheng, W. (2019) Protective Mechanism of Artemisinin on Rat Bone Marrow-Derived Mesenchymal Stem Cells against Apoptosis Induced by Hydrogen Peroxide via Activation of c-Raf-Erk1/2-p90(rsk)-CREB Pathway. Stem Cell Res Ther 10 (1)
  13. Mohamed R, Cao Y, Afroz R, Xu S, Ta HT, Barras M, Zheng W, Little PJ, Kamato D. (2019) ROS directly activates transforming growth factor β type 1 receptor signalling in human vascular smooth muscle cells. Biochim Biophys Acta Gen Subj 1864(1), 1-8
  14. Jiang, Yizhou ; Yan, Fengxia ; Feng, Zhongping ; Lazarovici, Philip ; Zheng, Wenhua. (2019) Signaling Network of Forkhead Family of Transcription Factors (FOXO) in Dietary Restriction. Cells 9(1)
  15. Jiang, Yizhou ; Peng, Tangming ; Gaur, Uma ; Silva, Marta ; Little, Peter ; Chen, Zhong ; Qiu, Wei ; Zhang, Yandong ; Zheng, Wenhua. (2019) Role of Corticotropin Releasing Factor in the Neuroimmune Mechanisms of Depression: Examination of Current Pharmaceutical and Herbal Therapies. Frontiers in cellular neuroscience 13
  16. Zhao, Xia ; Fang, Jiankang ; Li, Shuai ; Gaur, Uma ; Xing, Xingan ; Wang, Huan ; Zheng, Wenhua. (2019) Artemisinin Attenuated Hydrogen Peroxide (H2O2)-Induced Oxidative Injury in SH-SY5Y and Hippocampal Neurons via the Activation of AMPK Pathway. International journal of molecular sciences 20(11)
  17. Peng, Tangming ; Jiang, Yizhou ; Farhan, Mohd ; Lazarovici, Philip ; Chen, Ligang ; Zheng, Wenhua. (2019) Anti-inflammatory Effects of Traditional Chinese Medicines on Preclinical in vivo Models of Brain Ischemia-Reperfusion-Injury: Prospects for Neuroprotective Drug Discovery and Therapy. Frontiers in pharmacology 10
  18. Li, Shuai; Chaudhary, Shubhash Chandra; Zhao, Xia; Gaur, Uma; Fang, Jiankang; Yan, Fengxia; Zheng, Wenhua. (2019) Artemisinin Protects Human Retinal Pigmented Epithelial Cells Against Hydrogen Peroxide-induced Oxidative Damage by Enhancing the Activation of AMP-active Protein Kinase. International journal of biological sciences 15(9), 2016-2028
  19. Kamato D, Burch M, Zhou Y, Mohamed R, Stow JL, Osman N, Zheng W, Little PJ. (2019) Individual Smad2 linker region phosphorylation sites determine the expression of proteoglycan and glycosaminoglycan synthesizing genes. Cell signaling 53, 365-373
  20. Zhao, X., Zeng, Z. W., Gaur, U., Fang, J., Peng, T., Li, S., and Zheng, W. (2019) Metformin Protects PC12 Cells and Hippocampal Neurons from H2O2 -Induced Oxidative Damage through Activation of AMPK Pathway. J Cell Physiol 234(9), 16619-16629
  21. Li, S., Zhao, X., Lazarovici, P., and Zheng, W. (2019) Artemether Activation of AMPK/GSK3β(Ser9)/Nrf2 Signaling Confers Neuroprotection Towards Beta-Amyloid-Induced Neurotoxicity in 3xTg Alzheimer’s Mouse Model. Oxid Med Cell Longev, 1-24
  22. Mohamed R, Janke R, Guo W, Cao Y, Zhou Y, Zheng W, Babaahmadi-Rezaei H, Xu S, Kamato D, Little PJ. (2019) GPCR transactivation signalling in vascular smooth muscle cells: role of NADPH oxidases and reactive oxygen species. Vasc Biol 1(1), 1-11
  23. Wang, B. B., Bao, S. Y., Zhang, Z. G., Zhou, X. Y., Wang, J., Fan, Y. H., Zhang, Y., Li, Y., Chen, L. H., Jia, Y. Z., Li, J., Li, M. X., Zheng, W.，et al. (2018) A Rare Variant in MLKL Confers Susceptibility to ApoE Varepsilon4-Negative Alzheimer’s Disease in Hong Kong Chinese Population. Neurobiol Aging 68, 160.e1-160.e7
  24. Peng, Tangming ; Huang, Changren ; Jiang, Yong ; Wan, Weifeng ; Yang, Xiaobo ; Liu, Aihua ; Chen, Ligang ; Zheng, Wenhua. (2018) Is Single Low-Profile Visualized Intraluminal Support (LVIS)-Assisted Coiling of Wide-Necked Ruptured Multiple Intracranial Aneurysms in One Stage Feasible? World neurosurgery 118, e388-e394
  25. Wang, Haitao ; Su, Xiaoying ; Fang, Jiankang ; Xin, Xingan ; Zhao, Xia ; Gaur, Uma ; Wen, Qiang ; Xu, Jiangping ; Little, Peter J. ; Zheng, Wenhua. (2018) Tanshinone IIA Attenuates Insulin Like Growth Factor 1-Induced Cell Proliferation in PC12 Cells through the PI3K/Akt and MEK/ERK Pathways. International journal of molecular sciences 19(9)
  26. Wang, Haitao ; Xu, Jiangping ; Lazarovici, Philip ; Quirion, Remi ; Zheng, Wenhua. (2018) cAMP Response Element-Binding Protein (CREB): A Possible Signaling Molecule Link in the Pathophysiology of Schizophrenia. Frontiers in molecular neuroscience 11
  27. Li, Shuai ; Gaur, Uma ; Chong, Cheong-Meng ; Lin, Shaofen ; Fang, Jiankang ; Zeng, Zhiwen ; Wang, Haitao ; Zheng, Wenhua. (2018) Berberine Protects Human Retinal Pigment Epithelial Cells from Hydrogen Peroxide-Induced Oxidative Damage through Activation of AMPK. International journal of molecular sciences 19(6)
  28. Yan, Fengxia ; Liao, Rifang ; Lin, Shaofen ; Deng, Xianguo ; Little, Peter J. ; Zheng, Wenhua. (2018) Forkhead box protein O3 suppresses uveal melanoma development by increasing the expression of Bcl-2-like protein 11 and cyclin-dependent kinase inhibitor 1B. Molecular medicine reports 17(2), 3109-3114
  29. Wang, Haitao ; Gaur, Uma ; Xiao, Jiao ; Xu, Bingtian ; Xu, Jiangping ; Zheng, Wenhua. (2018) Targeting phosphodiesterase 4 as a potential therapeutic strategy for enhancing neuroplasticity following ischemic stroke. International journal of biological sciences 14(12), 1745-1754
  30. Muhamad A. Rostam, Aravindra Shajimoon, Danielle Kamato, Partha Mitra, Terrence J. Piva, Robel Getachew, Yingnan Cao, Wenhua Zheng, Narin Osman and Peter J. Little. (2018) Flavopiridol Inhibits TGF-β-Stimulated Biglycan Synthesis by Blocking Linker Region Phosphorylation and Nuclear Translocation of Smad2. Journal of Pharmacology and Experimental Therapeutics 365(1), 156-164
  31. Jiajia Chen, Hui Yu, Jiahong Zhong, Hongfang Feng, Haitao Wang, Zhengqiang Zou, Chang Huang, Zhongzhen Zhou, Wenhua Zheng, Jiangping Xu. (2018) The phosphodiesterase-4 inhibitor, FCPR16, attenuates ischemia-reperfusion injury in rats subjected to middle cerebral artery occlusion and reperfusion. Brain research bulletin 137, 98-106
  32. Afroz, R., Cao, Y. N., Rostam, M. A., Ta, H., Xu, S. W., Zheng, W., Osman, N., Kamato, D., and Little, P. (2018) Signalling Pathways Regulating Galactosaminoglycan Synthesis and Structure in Vascular Smooth Muscle: Implications for Lipoprotein Binding and Atherosclerosis. Pharmacol Therapeut 187, 88-97
  33. Liao, R. F., Yan, F. X., Zeng, Z. P., Wang, H. T., Qiu, K. F., Xu, J. Y., and Zheng, W. (2018) Insulin-Like Growth Factor-1 Activates PI3K/Akt Signalling to Protect Human Retinal Pigment Epithelial Cells from Amiodarone-Induced Oxidative Injury. Brit J Pharmacol 175(1), 125-139
  34. Liao, Rifang ; Yan, Fengxia ; Zeng, Zhuanping ; Farhan, Mohd ; Little, Peter ; Quirion, Remi ; Srivastava, Lalit K. ; Zheng, Wenhua. (2017) Amiodarone-Induced Retinal Neuronal Cell Apoptosis Attenuated by IGF-1 via Counter Regulation of the PI3k/Akt/FoxO3a Pathway. Molecular neurobiology 54(9), 6931-6943
  35. Zheng, W., Meng, Q., Wang, H. T., Yan, F. X., Little, P. J., Deng, X. G., and Lin, S. F. (2017) IGF-1-Mediated Survival from Induced Death of Human Primary Cultured Retinal Pigment Epithelial Cells Is Mediated by an Akt-Dependent Signaling Pathway. Mol Neurobiol 55(3), 1915-1927
  36. Wang, Haitao ; Xu, Jiangping ; Lazarovici, Philip ; Zheng, Wenhua. (2017) Dysbindin-1 Involvement in the Etiology of Schizophrenia. International journal of molecular sciences 18(10)
  37. Zeng, Zhiwen ; Wang, Dejun ; Gaur, Uma ; Liao Rifang ; Wang, Haitao ; Zheng, Wenhua. (2017) H2O2 attenuates IGF-1R tyrosine phosphorylation and its survival signaling properties in neuronal cells via NR2B containing NMDA receptor. Oncotarget 8(39), 65313-65328
  38. Wang, Haitao ; Farhan, Mohd ; Xu, Jiangping ; Lazarovici, Philip ; Zheng, Wenhua. (2017) The involvement of DARPP-32 in the pathophysiology of schizophrenia. Oncotarget 8(32), 53791-53803
  39. Wang, Rikang ; Yan, Fengxia ; Liao, Rifang ; Wan, Pei ; Little, Peter J. ; Zheng, Wenhua. (2017) Role of brain-derived neurotrophic factor and nerve growth factor in the regulation of Neuropeptide W in vitro and in vivo. Molecular and cellular endocrinology 447, 71-78
  40. Farhan, Mohd ; Wang, Haitao ; Gaur, Uma ; Little, Peter J. ; Xu, Jiangping ; Zheng, Wenhua. (2017) FOXO Signaling Pathways as Therapeutic Targets in Cancer. International journal of biological sciences 13(7), 815–827
  41. Zeng, Z. W., Xu, J. Y., and Zheng, W. H. (2017) Artemisinin Protects PC12 Cells against β-Amyloid-Induced Apoptosis through Activation of the Erk1/2 Signaling Pathway. Redox Biol 12, 625-633
  42. Kamato, D., Mitra, P., Davis, F., Osman, N., Chaplin, R., Cabot, P., Afroz, R., Thomas, W., Zheng, W., Kaur, H., Brimble, M., and Little, P. (2017) Gaq Proteins: Molecular Pharmacology and Therapeutic Potential. Cell Mol Life Sci 74 (8), 1379-1390
  43. Zeng, Z. W., Wang, X., Bhardwaj, S., Zhou, X. H., Little, P., Quirion, R., Srivastava, L., and Zheng, W. (2017) The Atypical Antipsychotic Agent, Clozapine, Protects against Corticosterone-Induced Death of PC12 Cells by Regulating the Akt/Foxo3a Signaling Pathway. Mol Neurobiol 54(5), ‏ 3395-3406
  44. Yan, F. X., Wang, H. T., Gao, Y., Xu, J. P., and Zheng, W. (2017) Artemisinin Protects Retinal Neuronal Cells against Oxidative Stress and Restores Rat Retinal Physiological Function from Light Exposed Damage. Acs Chem Neurosci 8(8), 1713-1723
  45. Linlin, L.; Zeng, Z.; Gaur, U.; Yan, F.; Zheng, W., (2017) The p38-MAPK Pathway Is Involved in Neuroprotection of Artemisinin against H2O2-induced Apoptosis in PC12 Cells. Journal of Pharmacy and Pharmacology 7, 416-423
  46. You T, Cheng Y, Zhong J, Bi B, Zeng B, Zheng W, Wang H, Xu J. (2017) Roflupram, a Phosphodiesterase 4 Inhibitior, Suppresses Inflammasome Activation through Autophagy in Microglial Cells. ACS Chem Neurosci 8(11), 2381-2392
  47. Zou, Z.Q.; Chen, J.J.; Feng, H.F.; Cheng, Y.F.; Wang, H.T.; Zhou, Z.Z.; Guo, H.B.; Zheng, W.; Xu, J.P. (2017) Novel Phosphodiesterase 4 Inhibitor FCPR03 Alleviates Lipopolysaccharide-Induced Neuroinflammation by Regulation of the cAMP/PKA/CREB Signaling Pathway and NF-κB Inhibition. Journal of Pharmacology and Experimental Therapeutics 362(1), 67-77
  48. Kamato D, Bhaskarala VV, Mantri N, Oh TG, Ling D, Janke R, Zheng W, Little PJ, Osman N. (2017) RNA sequencing to determine the contribution of kinase receptor transactivation to G protein coupled receptor signalling in vascular smooth muscle cells. PLoS One12(7)
  49. Liu L, Zeng Z, Gaur U, Fang J, Little PJ and Zheng W. (2017) Berberine protect pc12 cells from H2O2 induced oxidative damage through activation of ERK1/2 pathways. Journal of Clinical and Experimental Pharmacology 7.
  50. Ostrowski PP, Barszczyk A, Forstenpointner J, Zheng W, Feng ZP. (2016) Meta-Analysis of Serum Insulin-Like Growth Factor 1 in Alzheimer’s Disease. PLoS One 11(5)
  51. Al Gwairi O, Osman N, Getachew R, Zheng W, Liang XL, Kamato D, Thach L, Little PJ. (2016) Multiple Growth Factors, But Not VEGF, Stimulate Glycosaminoglycan Hyperelongation in Retinal Choroidal Endothelial Cells. Int J Biol Sci 12(9), 1041-1051
  52. Al Gwairi O, Thach L, Zheng W, Osman N, Little PJ. (2016) Cellular and Molecular Pathology of Age-Related Macular Degeneration: Potential Role for Proteoglycans. J Ophthalmol
  53. Muhamad A Rostam, Danielle Kamato, Terence J Piva, Wenhua Zheng, Peter J Little, Narin Osman. (2016) The role of specific Smad linker region phosphorylation in TGF-β mediated expression of glycosaminoglycan synthesizing enzymes in vascular smooth muscle. Cell Signal 28(8), 956-966
  54. Danielle Kamato , Lyna Thach , Robel Getachew , Micah Burch , Morley D Hollenberg , Wenhua Zheng , Peter J Little , Narin Osman. (2016) Protease activated receptor-1 mediated dual kinase receptor transactivation stimulates the expression of glycosaminoglycan synthesizing genes. Cell Signal 28(1), 110-119
  55. Yan Fengxia ; Liao Rifang ; Farhan, Mohd ; Wang Tinghuai ; Chen Jiashu ; Zhong Wang ; Little, Peter J. ; Zheng Wenhua. (2016) Elucidating the role of the FoxO3a transcription factor in the IGF-1-induced migration and invasion of uveal melanoma cancer cells. Biomedicine＆pharmacotherapy 84, 1538-1550
  56. Zeng, Zhiwen ; Wang, Haitao ; Shang, Fu ; Zhou, Lihua ; Little, Peter J. ; Quirion, Remi ; Zheng, Wenhua. (2016) Lithium ions attenuate serum-deprivation-induced apoptosis in PC12 cells through regulation of the Akt/FoxO1 signaling pathways. Psychopharmacology 233, 785-794
  57. Wang, Rikang ; Zhao, Jiaqiang ; Zhang, Lei ; Peng, Lizhi ; Zhang, Xinyi ; Zheng, Wenhua ; Chen, Heru. (2016) Genipin Derivatives Protect RGC-5 from Sodium Nitroprusside-Induced Nitrosative Stress. International journal of molecular sciences 17(1)
  58. Chong, C. M., and Zheng, W. (2016) Artemisinin Protects Human Retinal Pigment Epithelial Cells from Hydrogen Peroxide-Induced Oxidative Damage through Activation of ERK/CREB Signaling. Redox Biol 9, 50-56
  59. Zheng, W., Chong, C. M., Wang, H. T., Zhou, X. H., Zhang, L., Wang, R. K., Meng, Q., Lazarovici, P., and Fang, J. K. (2016) Artemisinin Conferred ERK Mediated Neuroprotection to PC12 Cells and Cortical Neurons Exposed to Sodium Nitroprusside-Induced Oxidative Insult. Free Radical Bio Med 97, 158-167
  60. Little, P., Hollenberg, M., Kamato, D., Thomas, W., Chen, J., Wang, T., Zheng, W., and Osman, N. (2016) Integrating the GPCR Transactivation‐Dependent and Biased Signalling Paradigms in the Context of Par1 Signalling. Brit J Pharmacol 173 (20), 2992-3000
  61. Rebekah Bernard, Robel Getachew, Danielle Kamato, Lyna Thach, Narin Osman, Vincent Chan, Wenhua Zheng, Peter J Little. (2016) Evaluation of the potential synergism of imatinib-related poly kinase inhibitors using growth factor stimulated proteoglycan synthesis as a model response. J Pharm Pharmacol 68(3), 368-378
  62. Afroz R, Tanvir EM, Zheng W and Little PJ. (2016) Molecular Pharmacology of Honey. Journal of Clinical and Experimental Pharmacology 6(3), 1-13
  63. Al Gwairi O, Thach L, Zheng W, Osman N, Little PJ. (2016) Cellular and MolecularPathology of Age-Related Macular Degeneration: Potential Role for Proteoglycans. J Ophthalmol
  64. Fengxia Yan, Rifang Liao, Peter J. Little and Wenhua Zheng. (2016) FoxO3a suppressed uveal melanoma development via increasing the expression of Bim and p27 Kip1. Molecular Medicine Reports.
  65. Kamato D, Thach L, Bernard R, Chan V, Zheng W, Kaur H, Brimble M, Osman N, Little PJ. (2015) Structure, Function, Pharmacology, and Therapeutic Potential of the G Protein, Gα/q,11. Front Cardiovasc Med 2
  66. Wang, H. T., Quirion, R., Little, P., Cheng, Y. F., Feng, Z. P., Sun, H. S., Xu, J. P., and Zheng, W. (2015) Forkhead Box O Transcription Factors as Possible Mediators in the Development of Major Depression. Neuropharmacology 99, 527-537
  67. Wang, Rikang ; Peng, Lizhi ; Zhao, Jiaqiang ; Zhang, Laitao ; Guo, Cuiping ; Zheng, Wenhua ; Chen, Heru. (2015) Gardenamide A Protects RGC-5 Cells from H2O2-Induced Oxidative Stress Insults by Activating PI3K/Akt/eNOS Signaling Pathway. International journal of molecular sciences 16(9), ‏ 22350-22367
  68. Zhao, Jiaqiang ; Peng, Lizhi ; Zheng, Wenhua ; Wang, Rikang ; Zhang, Lei ; Yang, Jian ; Chen, Heru. (2015) Chemically Bonding of Amantadine with Gardenamide A Enhances the Neuroprotective Effects against Corticosterone-Induced Insults in PC12 Cells. International journal of molecular sciences 16(9), 22795-22810
  69. Wang R, Yang J, Peng L, Zhao J, Mu N, Huang J, Lazarovici P, Chen H, Zheng W. (2015) Gardenamide A attenuated cell apoptosis induced by serum deprivation insult via the ERK1/2 and PI3K/AKT signaling pathways. Neuroscience 286, 242-250
  70. Kamato D, Rostam MA, Bernard R, Piva TJ, Mantri N, Guidone D, Zheng W, Osman N, Little PJ. (2015) The expansion of GPCR transactivation-dependent signalling to include serine/threonine kinase receptors represents a new cell signaling frontier. Cell Mol Life Sci 72(4), 799-808
  71. Barszczyk A, Sun HS, Quan Y, Zheng W, Charlton MP, Feng ZP. (2015) Differential Roles of the Mevalonate Pathway in the Development and Survival of Mouse Purkinje Cells in Culture. Mol Neurobiol 51(3), 1116-1129
  72. Rostam MA, Piva TJ, Rezaei HB, Kamato D, Little PJ, Zheng W, Osman N. (2015) Peptidyl-prolyl isomerases: functionality and potential therapeutic targets in cardiovascular disease. Clin Exp Pharmacol Physiol 42(2), 117-124
  73. Chen, Qian ; Wang, Haitao ; Liao, Sufen ; Gao, Yang ; Liao, Rifang ; Little, Peter J. ; Xu, Jiangping ; Feng, Zhong-Ping ; Zheng, Yongxin ; Zheng, Wenhua. (2015) Nerve growth factor protects retinal ganglion cells against injury induced by retinal ischemia-reperfusion in rats. Growth factors 33(2), 149-159
  74. Haitao Wang，Jiangping Xu，Jiashu Chen，Peter J Little，Wenhua Zheng (2015) Role of IGF-1 signaling in the pathology of diabetic retinopathy. Therapeutic Targets for Neurological Diseases.
  75. Kamato D, Rostam MA, Piva TJ, BabaahmadiRezaei H, Getachew R, ThachL,Bernard R, Zheng W, Little PJ, Osman N. (2014) Transforming growth factor β-mediated site-specific Smad linker region phosphorylation in vascular endothelial cells. J Pharm Pharmacol 66(12),1722-33
  76. Wang H, Wang R, Thrimawithana T, Little PJ, Xu J, Feng ZP, Zheng W. (2014) The nerve growth factor signaling and its potential as therapeutic target for glaucoma. Biomed Res Int
  77. Al-aryahi S, Kamato D, Getachew R, Zheng W, Potocnik SJ, Cohen N, Guidone D, Osman N, Little PJ. (2014) Atherogenic, fibrotic and glucose utilising actions of glucokinase activators on vascular endothelium and smooth muscle. Cardiovasc Diabetol 13
  78. Wang R, Yang J, Liao S, Xiao G, Luo J, Zhang L, Little PJ, Chen H, Zheng W. (2014) Stereoselective reduction of 1-o-isopropyloxygenipin enhances its neuroprotective activity in neuronal cells from apoptosis induced by sodium nitroprusside. Chem Med Chem 9(7),1397-401
  79. Osman N, Getachew R, Thach L, Wang H, Su X, Zheng W, Little PJ. (2014) Platelet-derived growth factor-stimulated versican synthesis but not glycosaminoglycan elongation in vascular smooth muscle is mediated via Akt phosphorylation. Cell Signal 26(5), 912-916
  80. Kamato D, Burch ML, Piva TJ, Rezaei HB, Rostam MA, Xu S, Zheng W, Little PJ, Osman N. (2013) Transforming growth factor-β signalling: role and consequences of Smad linker region phosphorylation. Cell Signal 25(10), 2017-2024
  81. Kamato D, BabaahmadiRezaei H, Getachew R, Thach L, Guidone D, Osman N,Roufogalis B, Duke CC, Tran VH, Zheng W, Little PJ. (2013) (S)-[6]-Gingerol inhibits TGF-β-stimulated biglycan synthesis but not glycosaminoglycan hyperelongation in  human vascular smooth muscle cells. J Pharm Pharmacol 65(7),1026-1036
  82. Wang, Haitao; Zhou, Xuanhe; Huang, Jianchu; Mu, Nan; Guo, Zeli; Wen, Qiang; Wang, Rikang; Chen, Shaorui; Zheng, Wenhua. (2013) The Role of Akt/FoxO3a in the Protective Effect of Venlafaxine against Corticosterone-induced Cell Death in PC12 cells. Psycopharmacology 228(1), 129-141
  83. Zheng W, Zeng Z, Bhardwaj SK, Jamali S, Srivastava LK. (2013) Lithium normalizes amphetamine-induced changes in striatal FoxO1 phosphorylation and behaviors in rats. Neuroreport 24(10), 560-565
  84. Kamato D, Burch ML, Osman N, Zheng W, Little PJ. (2013) Therapeutic implications of endothelin and thrombin G-protein-coupled receptor transactivation of tyrosine and serine/threonine kinase cell surface receptors. J Pharm Pharmacol 65(4):465-473
  85. Haitao Wang, Xiaolu Duan, Yannan Ren, Yizhi Liu, Min Huang, Peiqing Liu, Rikang Wang, Guoquan Gao, Lihua Zhou, Zhongping Feng,Wenhua Zheng. (2013) FoxO3a negatively regulates nerve growth factor-induced neuronal differentiation through inhibiting the expression of neurochondrin in PC12 cells. Mol Neurobiol 47(1), 24-36
  86. Little PJ, Rostam MA, Piva TJ, Getachew R, Kamato D, Guidone D, Ballinger ML, Zheng W, Osman N. (2013) Suramin inhibits PDGF-stimulated receptor phosphorylation, proteoglycan synthesis and glycosaminoglycan hyperelongation in human vascular smooth muscle cells. J Pharm Pharmacol 65(7):1055-1063
  87. WenhuaZheng, Haitao Wang, ZhiwenZeng, Jun Lin, Peter J Little, Lalit K Srivastava, RemiQuirion. (2012) The possible role of the Akt signaling pathway in schizophrenia. Brain Research 1470,145-158
  88. Haitao Wang, Qishan Zhang, Qiang Wen, Lazarovici Philip, Hao Jiang and WenhuaZheng. (2012) Proline-rich Akt substrate of 40 kDa (PRAS40): A novel downstream target of PI3k/Akt signaling pathway. cell signal 24(1),17-24
  89. Sun C, Meng Q, Zhang L, Wang H, Quirion R, Zheng W. (2012) Glutamate attenuates IGF-1 receptor tyrosine phosphorylation in mouse brain: Possible significance in ischemic brain damage. Neurosci Res 74(3-4),290-297
  90. Haitao Wang, Qishan Zhang, Lang Zhang, Peter J Little, XiaochunXie, QianMeng, YannanRen, Lihua Zhou, GuoquanGao, RemiQuirion, WenhuaZheng. (2012) Insulin-like growth factor-1 induces the phosphorylation of PRAS40 via the PI3K/Akt signaling pathway in PC12 cells. Neuroscience Letters 516(1), 105-109
  91. Qiang Wen, Haitao Wang, Peter J. Little, RemiQuirion, WenhuaZheng. (2012) Forkhead Family Transcription Factors FoxO and Neural Differentiation. Neurogenetics 13(2):105-113
  92. Luo J, Wang R, Huang Z, Yang J, Yao X, Chen H, Zheng W. (2012) Synthesis of stable genipin derivatives and studies of their neuroprotective activity in PC12 cells. Chem Med Chem 7(9):1661-1668
  93. Burch ML, Osman N, Getachew R, Al-Aryahi S, Poronnik P, Zheng W, Hill MA, Little PJ. (2012) G protein coupled receptor transactivation: Extending the paradigm to include serine/threonine kinase receptors. Int J Biochem Cell Biol 44(5):722-727
  94. Zhao X, Wang L, Wang Y , Song F ,Li Y, Fu R, Zheng W, Wu T, Zhou L. (2012) Activation of phospholipase-Cγ and protein kinase C signal pathways helps the survival of spinal motoneurons injured by root avulsion. J Neurochem 121(3):362-372
  95. Cheng X, Liu S, Wang YQ, Li YQ, Fu R, Tang Y, Zheng WH, Zhou LH. (2012) Suppression of c-jun influences nNOS expression in differentiated PC12 cells. Mol Med Report 6(4):750-754
  96. Osman N, Getachew R, Burch M, Lancaster G, Wang R, Wang H, Zheng W, Little PJ. (2011) TGF-β stimulates biglycan core protein synthesis but not glycosaminoglycan chain elongation via Akt phosphorylation in vascular smooth muscle. Growth Factors 29(5), 203-210
  97. Wen Q, Duan X, Liao R, Little P, Gao G, Jiang H, Lalit S, Quirion R, Zheng W. (2011) Characterization of intracellular translocation of Forkhead transcription factor O (FoxO) members induced by NGF in PC12 cells. NeurosciLett 498(1):31-36
  98. Little PJ, Burch ML, Al-aryahi S, Zheng W. (2011) The paradigm of G protein receptor transactivation: a mechanistic definition and novel example. Scientific World Journal 11:709-714
  99. Burch ML, Zheng W, Little PJ. (2011) Smad linker region phosphorylation in the regulation of extracellular matrix synthesis. Cell Mol Life Sci 68(1):97-107
  100. WenhuaZheng and Rémi Quirion. (2009) Glutamate acting on N-methyl-D-aspartate receptors attenuates insulin-like growth factor-1 receptor tyrosine phosphorylation and its survival signaling properties in rat hippocampal neurons. J Biol Chem 284(2):855-861
  101. Zhang F, Zheng W, Pi R, Mei Z, Bao Y, Gao J, Tang W, Chen S, Liu P. (2009) Cryptotanshinone protects primary rat cortical neurons from glutamate-induced neurotoxicity via the activation of the PI3K/Akt signaling pathway. Exp Brain Res 193(1):109-118
  102. Mei Z, Zhang F, Tao L, Zheng W, Cao Y, Wang Z, Tang S, Le K, Chen S, Pi R, Liu P. (2009) Cryptotanshinone, a compound from Salvia miltiorrhiza modulates amyloid precursor protein metabolism and attenuates beta-amyloid deposition through upregulating alpha-secretase in vivo and in vitro. NeurosciLett 452(2):90-95
  103. Ivanisevic L, Zheng W, Woo SB, Neet KE, Saragovi HU. (2007) TrkA receptor “hot spots” for binding of NT-3 as a heterologous ligand. J Biol Chem 282(23),16754-16763
  104. Li R, Zheng W, Pi R, Gao J, Zhang H, Wang P, Le K, Liu P. (2007) Activation of peroxisome proliferator-activated receptor-alpha prevents glycogen synthase 3beta phosphorylation and inhibits cardiac hypertrophy. FEBS Lett 581(17), 3311-3316
  105. Zheng WH, Quirion R. (2006) Insulin-like growth factor-1 (IGF-1) induces the activation/phosphorylation of Akt kinase and cAMP response element-binding protein (CREB) by activating different signaling pathways in PC12 cells. BMC Neurosci 7,
  106. Takhshid MA, Poyner DR, Chabot JG, Fournier A, Ma W, Zheng WH, Owji AA, Quirion R. (2006) Characterization and effects on cAMP accumulation of adrenomedullin and calcitonin gene-related peptide (CGRP) receptors in dissociated rat spinal cord cell culture. Br J Pharmacol 148(4), 459-468
  107. Gan L, Zheng W, Chabot JG, Unterman TG, Quirion R. (2005) Nuclear/cytoplasmic shuttling of the transcription factor FoxO1 is regulated by neurotrophic factors. J Neurochem 93(5), 1209-1219
  108. Cui QL, Zheng WH, Quirion R, AlmazanG. (2005) Inhibition of Src-like kinases reveals Akt-dependent and -independent pathways in insulin-like growth factor I-mediated oligodendrocyte progenitor survival. J Biol Chem 280(10):8918-8928
  109. Zheng WH, and Quirion R. (2004) Comparative intercellular signaling of IGF-1 and BDNF in hippocampal neurons and the role of PI3K/Akt pathway in cell survival. J. Neurochem 89(4):844-852
  110. Nitta A, Zheng WH, Quirion R. (2004) Insulin-like growth fasctor-1 prevent neuronal cell death induced by corticosterone through the activation of Akt kinase. J. Neurosci. Research 76(1):98-103
  111. Han YS, Zheng WH, Bastianetto S, and Quirion R. (2004) Neuroprotective effects of resveratrol against beta-amyloid-induced neurotoxicity in rat hippocampal neurons: involvement of protein kinase C. Br. J. Pharmacol 141(6):997-1005
  112. Zheng WH, Bastianetto, Mennichken F., Ma R, Quirion R, Kar S. (2002) Amyloid beta peptide-induced tau phosphorylation and neuronal degeneration in rat primary septal cultured neurons. Neuroscience 115(1):201-211
  113. Zheng WH, Kar S, Quirion R. (2002) Insulin-like growth factor-1-induced phosphorylation of transcription factor FKHRL1 is mediated by phosphatidylinositol 3-kinase/Akt kinase and role of this pathway in insulin-like growth factor-1-induced survival of cultured hippocampal neurons. Mol Pharmacol 62(2), 225-233
  114. Zheng WH, Kar S, Quirion R. (2002) FKHRL1 and its homologs are new targets of nerve growth factor Trk receptor signaling. J Neurochem 80(6):1049-1061
  115. Seto D, Zheng WH, McNicoll A, Collier B, Quirion R, Kar S. (2002) Insulin-like growth factor-I inhibits endogenous acetylcholine release from the rat hippocampal formation: possible involvement of GABA in mediating the effects. Neuroscience 115(2), 603-612
  116. Ma W, Zheng WH, Powell K, Jhamandas K, Quirion R. (2001) Chronic morphine exposure increases the phosphorylation of MAP kinases and the transcription factor CREB in dorsal root ganglion neurons: an in vitro and in vivo study. Eur J Neurosci 14(7), 1091-1104
  117. Ma W, Zheng WH, Belanger S, Kar S, Quirion R. (2001) Effects of amyloid peptides on cell viability and expression of neuropeptides in cultured rat dorsal root ganglion neurons: a role for free radicals and protein kinase C. Eur J Neurosci 13(6),1125-1135
  118. Burgess K, Han I, Zhang A, Zheng WH, Shanmugam K, Featherstone MS, Saragovi HU. (2001) DiSSiMiL: Diverse Small Size Mini-Libraries applied to simple and rapid epitope mapping of a monoclonal antibody. J Pept Res 57(1), 68-76
  119. Zheng WH, Kar S, Quirion R. (2000) Insulin-like growth factor-1-induced phosphorylation of the forkhead family transcription factor FKHRL1 is mediated by Akt kinase in PC12 cells. J Biol Chem 275(50), 39152-39158
  120. Zheng WH, Kar S, Quirion R. (2000) Stimulation of protein kinase C modulates insulin-like growth factor-1-induced Akt activation in PC12 cells. J Biol Chem 275(18),13377-13385
  121. Bastianetto S, Zheng WH, Quirion R. (2000) Neuroprotective abilities of resveratrol and other red wine constituents against nitric oxide-related toxicity in cultured hippocampal neurons. Br J Pharmacol 131(4), 711-720
  122. Ma W, Zheng WH, Kar S, Quirion R. (2000) Morphine treatment induced calcitonin gene-related peptide and substance P increases in cultured dorsal root ganglion neurons. Neuroscience 99(3), 529-539
  123. Bastianetto S, Zheng WH, Quirion R. (2000) The Ginkgo biloba extract (EGb 761) protects an rescues hippocampal cells against nitric oxide-induced toxicity: involvement of its flavonoid constituents and protein kinase C. J Neurochem 74(6), 2268-2277
  124. Dore S, Kar S, Zheng WH, Quirion R. (2000) Rediscovering good old friend IGF-I in the new millenium: possible usefulness in Alzheimer’s disease and stroke. Pharm Acta Helv 74(2-3), 273-280
  125. Deng XF, Sculptoreanu A, Mulay S, Peri KG, Li JF, Zheng WH, Chemtob S, Varma DR. (1998) Crosstalk between alpha-1A and alpha-1B adrenoceptors in neonatal rat myocardium: implications in cardiac hypertrophy. J Pharmacol ExpTher 286(1):489-496
  126. Saragovi HU*, Zheng WH, Maliartchouk S, DiGugliemo GM, Mawal YR, Kamen A, Wo SB, Cuello AC, Debeir T, Neet KE. (1998) A TrkA-selective, fast internalizing nerve growth factor-antibody complex induces trophic but not neuritogenic signals. J Biol Chem 273(52), 34933-34940
  127. Dickens G, Lavarreda M, Zheng WH, Guroff G. (1997) Involvement of protein kinase C in nerve growth factor- and K-252a-stimulated calcium uptake into PC12 cells. J Neurosci Res 47(3), 271-276
  128. Zheng WH, Fink DW Jr, Guroff G. (1996) Role of protein kinase C alpha in nerve growth factor-induced arachidonic acid release from PC12 cells. J Neurochem 66(5),1868-1875
  129. 孟茜,鄭文華. 隱丹參酮對IGF-1促PC12細胞存活的作用及機制探討[J]. 中國實驗方劑學雜誌,2013,10:195-198.
  130. 蘇肖英,汪海濤,孟茜,Remi Quirion,鄭文華. 神經生長因數誘導神經幹細胞分化的作用機制探討[J]. 廣東醫學,2012,01:44-48.
  131. 段小鹿,汪海濤,廖素芬,黃健初,張浪,譚小燕,鄭文華. 神經生長因數對PC12細胞內源性FoxO3a亞細胞分佈的影響及其作用機制[J]. 廣東醫學,2012,05:575-578.
  132. 王德軍,鄭文華. 過氧化氫抑制PC12細胞IGF-1促存活功能的體外研究[J]. 山東醫藥,2012,24:19-21.
  133. 王雪,鄭文華. 多巴胺及其受體激動劑對PC12細胞增殖和Akt、ERK信號轉導的影響[J]. 山東醫藥,2011,11:49-50.
  134. 蘇肖英,汪海濤,孟茜,鄭文華. 不同生長因數對神經幹細胞定向分化的影響[J]. 廣東醫學,2011,09:1089-1091.
  135. 王雪,汪海濤,任豔囡,鄭文華. 多巴胺D1受體激動劑SKF38393對剝奪血清條件下PC12細胞的保護作用[J]. 中國神經精神疾病雜誌,2011,09:554-558.
  136. 孫承銘,謝岱希,鄭文華. 6-薑酚對腦缺血損傷模型小鼠的保護作用[J]. 山東醫藥, 2011,52:41-43+136.
  137. 張浪,賴永長,汪海濤,王日康,孟茜,鄭文華. 蘆丁對神經細胞氧化損傷的保護作用[J]. 中藥材,2014,04:640-644.
  138. 廖素芬,汪海濤,閆鳳俠,鄭永欣,曾志文,鄭文華. 二氫楊梅素對PC12細胞氧化損傷的保護及機制研究[J]. 中藥材,2014,06:1014-1020.
  139. 汪海濤,徐江平,周璿和,鄭文華. 抗抑鬱藥文拉法辛的神經保護作用及作用信號通路研究[A]..中國藥理通訊(2013年第三十卷第三期)[C]:2013:1