1. Wang, F., Sethiya, P., Hu, X., Guo, S., Chen, Y., Li, A., Tan, K. and Wong, K.H. “Transcription in fungal conidia before dormancy produces phenotypically variable conidia that maximize survival in different environments.” Nature Microbiology 2021; 6,1066–1081.
    。Featured on the cover page of August 2021 issue.
    。Featured in: Blatzer, M., Latgé, JP. Fungal spores are future-proofed. Nature Microbiology 2021;6,979–980.
  2. dos Reis T.F., Horta M.A.C., Colabardini A.C., Fernandes C.M., Silva L.P., Bastos R.W., Fonseca M.V.D.L., Wang F., Martins C., Rodrigues M.L., Silva Pereira C., Del Poeta M., Wong, K.H. and Goldman, G.H. “Screening of Chemical Libraries for New Antifungal Drugs against Aspergillus fumigatus Reveals Sphingolipids Are Involved in the Mechanism of Action of Miltefosine.” mBIO 2021;12(4): e01458-21.
  3. Zhang,, Cheung, C.Y., Seo, S., Liu, H., Pardeshi, L., Wong, K.H., Chow, L., Chau, M.P., Wang, Y., Lee, A.R., Kwon, W. Y., Chen, S., Chan, B.K., Wong, K., Choy, R.K.W. and Ko, B.C.B. “RUVBL1/2 Complex Regulates Pro-Inflammatory Responses in Macrophages via Regulating Histone H3K4 Trimethylation.” Frontiers in Immunology 2021;12:2074.
  4. Castro, P., Valero, C., Chiaratto, J., Colabardini, A.C., Pardeshi, L., Silva, L., Almeida, F., Rocha, M.C., Malavazi, I., Silva, R., Du, W., Dyer, P., Brock, M., Loures, F., Wong, K.H. and Goldman G. “Novel biological functions for the Aspergillus fumigatus NsdC transcription factor homologue involved in sexual development” mBIO 2021;12:e03102-20.
  5. Assis, L.J., Silva, L.P., Bayram, O., Dowling, P., Kniemeyer, O., Krüger, T., Brakhage, A.A., Chen, Y., Dong, L., Tan, K., Wong, K.H., Ries, L.N.A. and Goldman, G. “Carbon catabolite repression in filamentous fungi is regulated by phosphorylation of the transcription factor CreA” mBIO 2021;12:e03146-20.
  6. Wang, H., Guo, S., Kim, S.J., Shao, F., Ho, J.W.K., Wong, K.U., Miao, Z., Hao, D., Zhao, M., Xu, J., Zeng, J., Wong, K.H., Di, L., Wong, A.H.H., Mishra, L., Xu, X. and Deng, C.X. “Cisplatin prevents cancer metastasis through blocking early EMT and retards cancer growth synergistically with paclitaxel” Theranostics 2021; 11(5):2442-2459.
  7. Liu, J., Adhav, R., Miao, K., Su, S.M., Mo, L., Chan, U.I., Zhang, X., Xu, J., Li, J., Shu, X., Zeng, J., Zhang, X., Lyu, X., Pardeshi, L., Tan, K., Sun, H., Wong, K.H., Deng, C.X. and Xu, X. “Characterization of BRCA1-deficient premalignant tissues and cancers identifies Plekha5as a tumor metastasis suppressor.” Nature Communications 2020; 11(1):4875.
    https://doi: 10.1038/s41467-020-18637-9
  8. Ries, L., Pardeshi, L., Dong, Z., Tan, K., Steenwyk, J., Cristina Colabardini, A., Filho, J., Preite, N., Almeida, F., Jose de Assis, L., Santos, R., Bowyer, P., Bromley, M., Owens, R., Doyle, S., Demasi, M., Hernández, D., Netto, L., Pupo, M., Rokas, A., Loures, F., Wong, K.H. * and Goldman, G.* “The Aspergillus fumigatus transcription factor RglT is essential for virulence, gliotoxin biosynthesis and self-protection.” PLoS Pathogen 2020; 16(7): e1008645. (* Co-corresponding author)
  9. Zhou, P., Chan, B., Wan, Y.K., Yuen, C., Choi, G., Li, X., Cheung, L., Tan, K., Wong, K.H., Chan, H.Y.E. and Wong, A.S.L “A Three-way combinatorial CRISPR screen for analyzing interactions among druggable targets.” Cell Reports 2020; 32, 108020.
  10. Kai, M., Lei, H., Valecha, M.V., Zhang, A., Xu, J., Wang, L., Lyu, X., Chen, S., Miao, Z., Zhang, X., Su, S., Shao, F., Rajendran, B.K., Bao, J., Zeng, J., Sun, H., Chen, P., Tan, K., Chen, Q., Wong, K.H., Xu, X. and Deng, C.X. “NOTCH1 Activation Compensates BRCA1 Deficiency and Promotes Triple-Negative Breast Cancer Formation.” Nature Communications 2020; 11, 3256.
  11. Valero, C., Colabardini, A.C., Chiaratto, J., Pardeshi, L., Castro, P., Filho, J.F., Silva, L., Rocha, M., Malavazi, I., Costa, J., Fill, T., Barros, M., Wong, S., Aimanianda, V., Wong, K.H. and Goldman G. “Aspergillus fumigatus transcription factors involved in the caspofungin paradoxical effect.” mBio 2020; 11:e00816-20.
    https://doi.org/10.1128/mBio .00816-20
  12. Vassiliadis, D., Wong, K.H., Blinco, J., Dumsday, G., Andrianopoulos, A. and Monahan, B. “Adaptation to industrial stressors through genomic and transcriptional plasticity in a bioethanol producing fission yeast isolate” G3:Genes|Genomes|Genetics 2020; volume 10(4):1375-1391.
  13. Sethiya, P., Rai, M.N., Rai, R., Parsania, C., Tan, K. and Wong, K.H. “Transcriptomic analysis reveals global and temporal transcription changes during Candida glabrata adaptation to an oxidative environment.” Fungal Biology 2020;124(5):427-439.
  14. Alder-Rangel, A., Idnurm, A., Brand, A.C., Brown, A.J.P., Gorbushina, A., Kelliher, C.M., Campos, C.B., Levin, D.E., Bell-Pedersen, D., Dadachova, E., …… Wong, K.H. et al. (2020). “The Third International Symposium on Fungal Stress – ISFUS.” Fungal Biology 2020; 124(5):235-252.
  15. Yan, J., Bhadra, P., Li, A., Sethiya, P., Qin, L., Tai, H.K., Wong, K.H. and Siu, S.W.I. “Deep-AmPEP30: Improve short antimicrobial peptides prediction with deep learning.” Molecular Therapy – Nucleic Acids
  16. Choi, G.C.G., Zhou, P., Yuen, C.T.L., Chan, B.K.C., Xu, F., Bao, S., Chu, H.Y., Thean, D., Tan, K., Wong, K.H., Zheng, Z. and Wong, A.S.L. “Combinatorial mutagenesis en masse optimizes the genome editing activities of SpCas9” Nature Methods 2019; 16:722-730.
  17. Vassiliadis, D., Wong, K.H., Andrianopoulos, A. and Monahan, B.J. “A genome-wide analysis of carbon catabolite repression in Schizosaccharomyces pombe.” BMC Genomics 2019; 20(1):251.
  18. Petrenko, N., Jin, Y., Dong, L., Wong, K.H. *# and Struhl, K#. “Requirements for RNA polymerase II preinitiation complex formation in vivo.” eLife 2019; 8:e43654. (# Corresponding author)
  19. Kim, S.H., Iyer, K.R., Pardeshi, L., Munoz, J.F., Robbins, N., Cuomo, C.A., Wong, K.H. and Cowen, L.E. “Genetic analysis of Candida auris implicates Hsp90 in morphogenesis and Azole tolerance and Cdr1 in Azole resistance.” mBio 2019; 10(1). pII:e02529-18.
  20. Qin, L., Li, A., Tan, K., Guo, S., Chen, Y., Wang, F. and Wong, K.H. “Universal plasmids to facilitate gene deletion and gene tagging in filamentous fungi.” Fungal Genetics and Biology 2019; 125:28-35.
  21. Tan, K. and Wong, K.H. “RNA polymerase II ChIP-seq—a powerful and highly affordable method for studying fungal genomics and physiology.” Biophysical Reviews
  22. Zhang, B., Lyu, J., Liu, Y., Wu, C., Yang, E.J., Pardeshi, L., Tan, K., Wong, K.H., Chen, Q., Xu, X., Deng C. and Shim, J.S. “BRCA1 deficiency sensitizes breast cancer cells to bromodomain and extra-terminal domain (BET) inhibition.” Oncogene 2018; 37:6341-6356.
  23. Sun, H., Miao, Z., Zhang, X., Chan, U.I., Su, S.M., Guo, S., Wong, K.H., Xu, X., and Deng. C.X. “Single-cell RNA-Seq reveals cell heterogeneity and hierarchy within mouse mammary epithelia.” Journal of Biological Chemistry 2018; 293(22) 8315–8329.
  24. Wang, H., Pardeshi, L.A., Rong, X., Li, E., Wong, K.H., Peng, Y., and Xu, R.H. “Novel variants identified in multiple sclerosis patients from southern China.” Frontiers in Neurology 2018; 9:582.
  25. Veri, A.O., Miao, Z., Shapiro, R.S., Tebbji, F., O’Meara, T.R., Kim, S.H., Colazo, J., Tan, K., Vyas, V.K., Whiteway, M., Robbins, N., Wong, K.H., and Cowen L.E. “Tuning Hsf1 levels drives distinct fungal morphogenetic programs with depletion impairing Hsp90 function and overexpression expanding the target space.” PLoS Genetics 2018; 14(3): e1007270.
  26. Xie, J.L., Qin, L., Miao, Z., Grys, B.T., Diaz, J.D.L.C., Ting, K., Krieger, J.R., Tong, J., Tan, K., Leach, M.D., Ketela, T., Moran, M.F., Krysan, D.J., Boone, C., Andrews, 
 B.J., Selmecki, A., Wong, K.H., Robbins, N. and Cowen, L.E. “The Candida albicans Transcription Factor Cas5 Couples Stress Responses, Drug Resistance, and Cell Cycle Regulation.” Nature Communications 2017; 8(1):499.
  27. Petrenko, N.*, Jin, Y.*, Wong, K.H.* and Struhl, K. “Evidence that Mediator is essential for Pol II transcription, but is not a required component of the preinitiation complex in vivo.” eLife 2017; 6:e28447. (* Equal contribution)
  28. Jiang, B., Yan, L., Miao, Z., Li, E.-Q., Wong, K.H. and Xu, R.-H. “Spheroidal formation preserves human stem cells for prolonged time under ambient conditions for facile storage and transportation.” Biomaterials 2017; 133:275-86.
  29. Szot, P.S., Yang, A., Wang, X., Parsania, C., Rohm, U., Wong, K.H. and Ho, J.W.K. “PBrowse: a web-based platform for real-time collaborative exploration of genomic data.” Nucleic Acids Research. 2017; 45 (9): e67.
  30. Petrenko, N.*, Jin, Y.*, Wong, K.H.*# and Struhl, K#. “Mediator undergoes a compositional change during transcriptional activation.” Molecular Cell. 2016; 64(3):443-454. (* Equal contribution; # Corresponding author)
    Featured in: Malik, S., and Roeder, G.R. “Mediator: A Drawbridge across the Enhancer-Promoter Divide.” Molecular Cell. 2016; 64(3):433-434.
  31. Leach, M.D., Farrer, R.A., Tan, K., Miao, Z., Walker, L.A., Cuomo, C.A., Wheeler, R.T., Brown, A.J.P., Wong, K.H. and Cowen, L.E. “Hsf1 and Hsp90 orchestrate temperature-dependent global transcriptional remodeling and chromatin architecture in Candida albicans.” Nature Communications. 2016 7:11704.
  32. Wong, K.H.*, Jin, Y.*, and Struhl, K. “TFIIH phosphorylation of the Pol II CTD stimulates Mediator dissociation from the preinitiation complex and promoter escape.” Molecular Cell. 2014; 54(4): 601-612. (* Equal contribution)
  33. Downes, D.J., Davis, M.A., Wong, K.H., Kreutzberger, S.D., Hynes, M.J., and Todd, R.B. “Dual DNA binding and coactivator functions of Aspergillus nidulans TamA, a Zn(II)2Cys6 transcription factor.” Molecular Microbiology. 2014 Jun;92(6):1198-211.
  34. Hunter, C.C., Siebert, K.S., Downes, D.J., Wong, K.H., Kreutzberger, S.D., Fraser, J.A., Clarke, D.F., Hynes, M.J., Davis, M.A., and Todd, R.B. “Multiple Nuclear Localization Signals Mediate Nuclear Localization of the GATA Transcription Factor AreA.” Eukaryotic Cell. 2014; 13(4):527-38.
  35. Wong, K.H.*, Jin, Y., and Moqtederi, Z. “Multiplex Illumina sequencing using DNA-barcoding.” Current Protocol in Molecular Biology. 2013; Chapter 7:Unit 7.11. (Invited protocol) (* Corresponding author)
  36. Suzuki, Y., Murray, S., Wong, K.H., Davis, M.A., and Hynes, M.J. “Reprogramming of carbon metabolism by the transcriptional activators AcuK and AcuM in Aspergillus nidulans.” Molecular Microbiology. 2012 84(5):942-64.
  37. Wong, K.H., and Struhl, K. “The Cyc8−Tup1 complex inhibits transcription primarily by masking the activation domain of the recruiting protein.” Genes and Development. 2011 Dec 1; 25: 2525-2539.
    Featured in: Parnell, E.J., and Stillman, D.J. “Shields up: the Tup1−Cyc8 repressor complex blocks coactivator recruitment.” Genes and Development. 2011 Dec 1, 25: 2429-2435.
  38. Tirosh, I.*, Wong, K.H.*, Barkai, N., and Struhl, K. “Extensive divergence of yeast stress responses through transitions between induced and constitutive activation.” Proceedings of the National Academy of Sciences of USA. 2011 Oct 4; 108(40):16693-8. (* Equal contribution)
  39. Suk, K., Choi, J., Suzuki, Y., Ozturk, SB., Mellor, JC., Wong, K.H., MacKay, JL., Gregory, R.I., and Roth, F.P. “Reconstitution of human RNA interference in budding yeast.” Nucleic Acids Research. 2011 Apr; 39(7):e43.
  40. Fan, X., Geisberg, J.V., Wong, K.H., and Jin, Y., “Conditional depletion of nuclear proteins by the anchor away system.” Current Protocol in Molecular Biology. 2011 Jan; Chapter 13:Unit13.10B. (Invited protocol)
  41. Wong, K.H., Hynes, M.J., Todd, R.B., and Davis, M.A. “Deletion and overexpression of the Aspergillus nidulans GATA factor AreB reveals unexpected pleiotropy.” Microbiology. 2009 Dec; 155(Pt 12):3868-80.
  42. Wong, K.H., Hynes, M.J., and Davis, M.A. “Recent advances in nitrogen regulation: a comparison between yeast and filamentous fungi.” Mini-review. Eukaryotic Cell. 2008 7(6):917-925.
  43. Wong, K.H., Todd, R.B., Oakley, B.R., Oakley, C.E, Hynes, M.J., and Davis, M.A. “Sumoylation in Aspergillus nidulans: sumO inactivation, overexpression and live-cell imaging.” Fungal Genetics and Biology. 2008 45:728-737.
  44. Wong, K.H., Hynes, M.J., Todd, R.B., and Davis, M.A. “Transcriptional control of nmrA by the bZIP transcription factor MeaB reveals a new level of nitrogen regulation in Aspergillus nidulans.” Molecular Microbiology. 2007 66(2):534-551.
  45. Todd, R.B., Fraser, J.A., Wong K.H., Davis, M.A., and Hynes, M.J. “Nuclear accumulation of the GATA factor AreA in response to complete nitrogen starvation by regulation of nuclear export. Eukaryotic Cell. 2005 4(10): 1646-1653.