2021-08-31T14:48:04+08:002021-02-02|Publish|
  1. Wang, F., Sethiya, P., Hu, X., Guo, S., Chen, Y., Li, A., Tan, K. and Wong, K.H. “Transcription in fungal conidia before dormancy produces phenotypically variable conidia that maximize survival in different environments.” Nature Microbiology 2021; 6,1066–1081.
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    。Featured on the cover page of August 2021 issue.
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  2. dos Reis T.F., Horta M.A.C., Colabardini A.C., Fernandes C.M., Silva L.P., Bastos R.W., Fonseca M.V.D.L., Wang F., Martins C., Rodrigues M.L., Silva Pereira C., Del Poeta M., Wong, K.H. and Goldman, G.H. “Screening of Chemical Libraries for New Antifungal Drugs against Aspergillus fumigatus Reveals Sphingolipids Are Involved in the Mechanism of Action of Miltefosine.” mBIO 2021;12(4): e01458-21.
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  3. Zhang,, Cheung, C.Y., Seo, S., Liu, H., Pardeshi, L., Wong, K.H., Chow, L., Chau, M.P., Wang, Y., Lee, A.R., Kwon, W. Y., Chen, S., Chan, B.K., Wong, K., Choy, R.K.W. and Ko, B.C.B. “RUVBL1/2 Complex Regulates Pro-Inflammatory Responses in Macrophages via Regulating Histone H3K4 Trimethylation.” Frontiers in Immunology 2021;12:2074.
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  4. Castro, P., Valero, C., Chiaratto, J., Colabardini, A.C., Pardeshi, L., Silva, L., Almeida, F., Rocha, M.C., Malavazi, I., Silva, R., Du, W., Dyer, P., Brock, M., Loures, F., Wong, K.H. and Goldman G. “Novel biological functions for the Aspergillus fumigatus NsdC transcription factor homologue involved in sexual development” mBIO 2021;12:e03102-20.
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  5. Assis, L.J., Silva, L.P., Bayram, O., Dowling, P., Kniemeyer, O., Krüger, T., Brakhage, A.A., Chen, Y., Dong, L., Tan, K., Wong, K.H., Ries, L.N.A. and Goldman, G. “Carbon catabolite repression in filamentous fungi is regulated by phosphorylation of the transcription factor CreA” mBIO 2021;12:e03146-20.
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  8. Ries, L., Pardeshi, L., Dong, Z., Tan, K., Steenwyk, J., Cristina Colabardini, A., Filho, J., Preite, N., Almeida, F., Jose de Assis, L., Santos, R., Bowyer, P., Bromley, M., Owens, R., Doyle, S., Demasi, M., Hernández, D., Netto, L., Pupo, M., Rokas, A., Loures, F., Wong, K.H. * and Goldman, G.* “The Aspergillus fumigatus transcription factor RglT is essential for virulence, gliotoxin biosynthesis and self-protection.” PLoS Pathogen 2020; 16(7): e1008645. (* Co-corresponding author)
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  9. Zhou, P., Chan, B., Wan, Y.K., Yuen, C., Choi, G., Li, X., Cheung, L., Tan, K., Wong, K.H., Chan, H.Y.E. and Wong, A.S.L “A Three-way combinatorial CRISPR screen for analyzing interactions among druggable targets.” Cell Reports 2020; 32, 108020.
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  10. Kai, M., Lei, H., Valecha, M.V., Zhang, A., Xu, J., Wang, L., Lyu, X., Chen, S., Miao, Z., Zhang, X., Su, S., Shao, F., Rajendran, B.K., Bao, J., Zeng, J., Sun, H., Chen, P., Tan, K., Chen, Q., Wong, K.H., Xu, X. and Deng, C.X. “NOTCH1 Activation Compensates BRCA1 Deficiency and Promotes Triple-Negative Breast Cancer Formation.” Nature Communications 2020; 11, 3256.
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  11. Valero, C., Colabardini, A.C., Chiaratto, J., Pardeshi, L., Castro, P., Filho, J.F., Silva, L., Rocha, M., Malavazi, I., Costa, J., Fill, T., Barros, M., Wong, S., Aimanianda, V., Wong, K.H. and Goldman G. “Aspergillus fumigatus transcription factors involved in the caspofungin paradoxical effect.” mBio 2020; 11:e00816-20.
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  12. Vassiliadis, D., Wong, K.H., Blinco, J., Dumsday, G., Andrianopoulos, A. and Monahan, B. “Adaptation to industrial stressors through genomic and transcriptional plasticity in a bioethanol producing fission yeast isolate” G3:Genes|Genomes|Genetics 2020; volume 10(4):1375-1391.
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  13. Sethiya, P., Rai, M.N., Rai, R., Parsania, C., Tan, K. and Wong, K.H. “Transcriptomic analysis reveals global and temporal transcription changes during Candida glabrata adaptation to an oxidative environment.” Fungal Biology 2020;124(5):427-439.
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  15. Yan, J., Bhadra, P., Li, A., Sethiya, P., Qin, L., Tai, H.K., Wong, K.H. and Siu, S.W.I. “Deep-AmPEP30: Improve short antimicrobial peptides prediction with deep learning.” Molecular Therapy – Nucleic Acids
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  16. Choi, G.C.G., Zhou, P., Yuen, C.T.L., Chan, B.K.C., Xu, F., Bao, S., Chu, H.Y., Thean, D., Tan, K., Wong, K.H., Zheng, Z. and Wong, A.S.L. “Combinatorial mutagenesis en masse optimizes the genome editing activities of SpCas9” Nature Methods 2019; 16:722-730.
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  17. Vassiliadis, D., Wong, K.H., Andrianopoulos, A. and Monahan, B.J. “A genome-wide analysis of carbon catabolite repression in Schizosaccharomyces pombe.” BMC Genomics 2019; 20(1):251.
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  19. Kim, S.H., Iyer, K.R., Pardeshi, L., Munoz, J.F., Robbins, N., Cuomo, C.A., Wong, K.H. and Cowen, L.E. “Genetic analysis of Candida auris implicates Hsp90 in morphogenesis and Azole tolerance and Cdr1 in Azole resistance.” mBio 2019; 10(1). pII:e02529-18.
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  20. Qin, L., Li, A., Tan, K., Guo, S., Chen, Y., Wang, F. and Wong, K.H. “Universal plasmids to facilitate gene deletion and gene tagging in filamentous fungi.” Fungal Genetics and Biology 2019; 125:28-35.
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  21. Tan, K. and Wong, K.H. “RNA polymerase II ChIP-seq—a powerful and highly affordable method for studying fungal genomics and physiology.” Biophysical Reviews
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  22. Zhang, B., Lyu, J., Liu, Y., Wu, C., Yang, E.J., Pardeshi, L., Tan, K., Wong, K.H., Chen, Q., Xu, X., Deng C. and Shim, J.S. “BRCA1 deficiency sensitizes breast cancer cells to bromodomain and extra-terminal domain (BET) inhibition.” Oncogene 2018; 37:6341-6356.
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  23. Sun, H., Miao, Z., Zhang, X., Chan, U.I., Su, S.M., Guo, S., Wong, K.H., Xu, X., and Deng. C.X. “Single-cell RNA-Seq reveals cell heterogeneity and hierarchy within mouse mammary epithelia.” Journal of Biological Chemistry 2018; 293(22) 8315–8329.
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  24. Wang, H., Pardeshi, L.A., Rong, X., Li, E., Wong, K.H., Peng, Y., and Xu, R.H. “Novel variants identified in multiple sclerosis patients from southern China.” Frontiers in Neurology 2018; 9:582.
    https://doi.org/10.3389/fneur.2018.00582
  25. Veri, A.O., Miao, Z., Shapiro, R.S., Tebbji, F., O’Meara, T.R., Kim, S.H., Colazo, J., Tan, K., Vyas, V.K., Whiteway, M., Robbins, N., Wong, K.H., and Cowen L.E. “Tuning Hsf1 levels drives distinct fungal morphogenetic programs with depletion impairing Hsp90 function and overexpression expanding the target space.” PLoS Genetics 2018; 14(3): e1007270.
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  27. Petrenko, N.*, Jin, Y.*, Wong, K.H.* and Struhl, K. “Evidence that Mediator is essential for Pol II transcription, but is not a required component of the preinitiation complex in vivo.” eLife 2017; 6:e28447. (* Equal contribution)
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