2022-07-08T14:50:58+08:002022-07-08|Publish|
  1. Cai J#, Zhang LC#, Zhao RJ, Pu LM, Chen KY, Nasim AA, Leung EL*, Fan XX*, Chelerythrine ameliorates rheumatoid arthritis by modulating the AMPK/mTOR/ULK-1 signaling pathway. Phytomedicine, 2022; 104:154140. (IF=6.656) https://doi.org/10.1016/j.phymed.2022.154140
  2. Wang YQ, Chen MT, Yu H, Yuan G, Luo L, Xu XF, Xu YN, Sui XB, Leung EL* and Wu QB*, The role and mechanism of action of natural compounds in the prevention and treatment of cancer and cancer metastasis. Frontiers in Bioscience-Landmark, 2022; 27(6):192. https://doi.org/10.31083/j.fbl2706192
  3. Wei CL, Khan MA, Du JM, Cheng JL, Tania M, Leung EL* and Fu JJ*, Cordyceptin inhibits triple-negative breast cancer cell migration and invasion by regulating EMT-TFs SLUG, TWIST1, SNAIL1, and ZEB1. Frontiers in Oncology, 2022; 12:898583. (IF=5.738) https://doi.org/10.3389/fonc.2022.898583
  4. Xie YJ, Huang M, Li D, Hou JC, Liang HH, Nasim AA, Huang JM, Xie C, Leung EL and Fan XX, Bacteria-based nanodrug for anticancer therapy. Pharmacological Research, 2022; 182:106282. (IF=10.334) https://doi.org/10.1016/j.phrs.2022.106282
  5. Xiong Q, Wan AT, Liu X, Fung CS, Xiao XJ, Malainua N, Hou JP, Wang LY, Wang MQ, Yan KY, Cui YB, Leung EL, Nong WY, Shin SK, Au SW, Jeong KY, Chew FT, Hui JH, Leung TF, Tungtrongchitr A, Zhong NS, Liu ZG, Tsui KW, Comparative genomics reveals insights into the divergent evolution of astigmatic mites and household pest adaptations. Molecular Biology and Evolution, 2022; 39(5):msac097. (IF=8.8) https://doi.org/10.1093/molbev/msac097
  6. Li JX, Li RZ, Ma LR, Wang P, Xu DH, Huang J, Li LQ, Tang L, Xie Y, Leung EL* and Yan PY*, , Targeting mutant Kirsten Rat Sarcoma Viral oncogene homolog in non-small cell lung cancer: current difficulties, integrative treatments and future perspectives. Frontiers in Pharmacology, 2022; 13:875330. (IF=5.988) https://doi.org/10.3389/fphar.2022.875330
  7. Liu J, Zhuang Y, Wu J, Wu Q, Liu M, Zhao Y, Liu Z, Wang C, Lu L, Meng Y, Lei K, Li X, Wu Q, Leung EL, Guo Z, Liu L, Li T, IKKβ mediates homeostatic function in inflammation via competitively phosphorylating AMPK and IκBα. Acta Pharmaceutica Sinica B, 2022; 12(2):651-664. (IF=14.903) https://doi.org/10.1016/j.apsb.2021.09.012
  8. Cao KY, Yan TM, Zhang JZ, Chan TF, Li J, Li C, Lai-Han Leung E, Gao J, Zhang BX, Jiang ZH, A TRPA1 tRNA-derived fragment from Chinese yew suppresses ovarian cancer growth via targeting. Molecular Therapy-Nucleic Acids, 2022; 27:718-732. (IF=10.183) https://doi.org/10.1016/j.omtn.2021.12.037
  9. Wang XR, Jiang ZB, Xu C, Meng WY, Liu P, Zhang YZ, Xie C, Yu JY, Xie YJ, Liang TL, Yan HX, Fan XX, Yao XJ*, Wu QB* and Leung EL*, Andrographolide suppresses non-small-cell lung cancer progression through induction of autophagy and antitumor immune response. Pharmacological Research, 2022; 179:106198. (IF=10.334) https://doi.org/10.1016/j.phrs.2022.106198
  10. Zheng L, Tan Y, Hu Y, Shen J, Qu Z, Chen X, Ho CL, Leung EL, Zhao W, Dai L, CRISPR/Cas-Based Genome Editing for Human Gut Commensal Species. ACS Synthetic Biology, 2022; 11(1):464–472. (IF=5.249) https://doi.org/10.1021/acssynbio.1c00543
  11. Hu W, Zhang J, Wang M, Chen W, Chai L, Leung EL, Tang Y, Clinical Features and Risk Factors Analysis for Hemorrhage in Adults on ECMO. Frontiers in Medicine, 2021; 8:731106. (IF=5.091) https://doi.org/10.3389/fmed.2021.731106
  12. Wang Y, Guo Y, Qiang S, Jin R, Li Z, Tang Y, Leung EL, Guo H, Yao X, 3D-QSAR, Molecular Docking, and MD Simulations of Anthraquinone Derivatives as PGAM1 Inhibitors. Frontiers in Pharmacology, 2021; 12:764351. (IF=5.81) https://doi.org/10.3389/fphar.2021.764351
  13. Zhang JM#, Zhang JH#, Liu Q, Fan XX, Leung EL*, Yao XJ*, Liu L*, Resistance looms for KRAS G12C inhibitors and rational tackling strategies. Pharmacology & Therapeutics, 2022; 229:108050. (IF=13.4) https://doi.org/10.1016/j.pharmthera.2021.108050
  14. Li KS#, Cheng HB#,Shen WX#, Leung EL, Le S, Yu LL, Xie H, Sui HB*, Zhu XM* and Wu QB*, Compound Taxus Chinensis capsule combined with chemotherapy for non-small-cell lung cancer: A PRISMA-compliant systematic review and meta-analysis of randomized controlled trials. Evidence-Based Complementary and Alternative Medicine, 2021; 2021:9535061. https://doi.org/10.1155/2021/9535061
  15. Zhang RN, Pan T, Xi Y, Zhang MM, Xie H, Liang ZM, Chen B, Xu C, Wang J, Huang XX, Zhu QR, Zhao ZM, Gao Q, Wen CY, Liu WC, Ma WR, Feng J, Sun XN, Duan T, Leung EL, Xie T*, Wu QB*, Sui XB*, Curcumenol triggered ferroptosis in lung cancer cells via lncRNA H19/ miR-19b-3p/FTH1 axis. Bioactive materials, 2022; 13:23-36. (IF=14.593) https://doi.org/10.1016/j.bioactmat.2021.11.013
  16. Liang TL#, Li RZ#, Mai CT#, Guan XX, Li JX, Wang XR, Ma LR, Zhang FY, Wang J, He F, Pan HD, Zhou H, Yan PY, Fan XX, Wu QB, Neher E, Liu L, Xie Y*, Leung EL*, Yao XJ*, A method establishment and comparison of in vivo lung cancer model development platforms for evaluation of tumour metabolism and pharmaceutical efficacy. Phytomedicine, 2022; 96:153831. (IF=5.34) https://doi.org/10.1016/j.phymed.2021.153831
  17. Zhang FY#, Li RZ#, Xu C#, Fan XX, Li JX, Meng WY, Wang XR, Liang TL, Guan XX, Pan HD, Liu L, Yao XJ, Wu QB* & Leung EL*, Emodin induces apoptosis and suppresses non-small-cell lung cancer growth via downregulation of sPLA2-Iia. Phytomedicine, 2022; 95:153786. (IF=5.34) https://doi.org/10.1016/j.phymed.2021.153786
  18. Wang Q, Zhang Q, Leung EL, Chen Y, Yao X, Exploring the thermodynamic, kinetic and inhibitory mechanisms of 5-iTU targeting mitotic kinase haspin by integrated molecular dynamics. Physical Chemistry Chemical Physics, 2021; 2021(23):18404-18413. https://doi.org/10.1039/d1cp02783b
  19. Liu Q, Wang Y, Leung EL, Yao X, In silico Study of Intrinsic Dynamics of Full-length apo-ACE2 and RBD-ACE2 complex. Computational and Structural Biotechnology Journal, 2021; 19:5455-5465. (IF=7.271) https://doi.org/10.1016/j.csbj.2021.09.032
  20. Bai SS, Cu SN, Wen WH, Leung EL, Bai J, Lin HY, Cui YF, Yang L, Liu ZQ, Zheng Y and Zhang R, Tanshinone IIA suppresses non-small cell lung cancer through Beclin-1-mediated autophagic apoptosis. Engineering, In Press. (IF=7.553) https://doi.org/10.1016/j.eng.2021.07.014
  21. Ma LR, Li JX, Tang L, Li RZ, Yang JS, Sun A, Leung EL, Yan PY, Immune checkpoints and immunotherapy in non-small cell lung cancer (NSCLC): novel study progression, difficulties and solutions. Oncology Letters, 2021; 22(5):787. https://doi.org/10.3892/ol.2021.13048
  22. Wang Q, Shao X, Leung EL, Chen Y, Yao X, Selectively targeting individual bromodomain: drug discovery and molecular mechanisms. Pharmacological Research, 2021; 172:105804. (IF=7.658) https://doi.org/10.1016/j.phrs.2021.105804
  23. Li JX, Li RZ, Sun A, Zhou H, Neher E, Yang JS, Huang JM, Zhang YZ, Jiang ZB, Liang TL, Ma LR, Wang J, Wang XR, Fan XQ, Huang J, Xie Y, Liu L, Tang L, Leung EL, Yan PY, Metabolomics and integrated network pharmacology analysis reveal Tricin as the active anti-cancer component of Weijing decoction by suppression of PRKCA and sphingolipid signaling. Pharmacological Research, 2021; 171:105574. (IF=7.658) https://doi.org/10.1016/j.phrs.2021.105574
  24. Zhong ZH, Yi ZL, Zhao YD, Wang J, Jiang ZB, Xu C, Xie YJ, He QD, Tong ZY, Yao XJ, Leung EL, Coghi PS, Fan XX, Chen M, Pyronaridine induces apoptosis in Non-small cell lung cancer cells by upregulating DR5 expression and inhibiting EGFR. Chemical Biology & Drug Design, 2022; 99:83-91. https://doi.org/10.1111/cbdd.13926
  25. Jiang ZB, Wang WJ, Xu C, Xie YJ, Wang XR, Zhang YZ, Huang JM, Huang M, Xie C, Liu P, Fan XX, Ma YP, Yan PY, Liu L, Yao XJ*, Wu QB*, Leung EL*, Luteolin and its derivative apigenin suppress the inducible PD-L1 expression to improve anti-tumor immunity in KRAS-mutant lung cancer. Cancer Letters, 2021; 515:36-48. (IF=8.679) https://doi.org/10.1016/j.canlet.2021.05.019
  26. Huang J#, Liu D#, Wang Y#, Liu L, Li J, Yuan J, Jiang Z, Jiang Z, Hsiao WW, Liu H, Khan I, Xie Y, Wu J, Xie Y, Zhang Y, Fu Y, Liao J, Wang W, Lai H, Shi A, Cai J, Luo L, Li R, Yao X, Fan X, Wu Q, Liu Z, Yan P, Lu J, Yang M, Wang L, Cao Y*, Wei H*, Leung EL*, Ginseng polysaccharides alter the gut microbiota and kynurenine/tryptophan ratio, potentiating the anti-tumor effect of anti-programmed cell death 1 /programmed cell death ligand 1 (anti-PD-1/PD-L1) immunotherapy. Gut, 2021; 71(4):734-745. (IF=23.059) https://doi.org/10.1136/gutjnl-2020-321031
  27. Chen HH#, Meng WY#, Li RZ#, Wang QY, Wang YQ, Pan HD, Yan PY, Wu QB, Liu L, Yao XJ*, Kang M* and Leung EL*, Potential prognostic factors in progression-free survival for patients with cervical cancer. BMC Cancer, 2021; 21:531. https://doi.org/10.1186/s12885-021-08243-3
  28. Jiang ZB, Xu C, Wang W, Zhang YZ, Huang JM, Xie YJ, Wang QQ, Fan XX, Yao XJ, Xie C, Wang XR, Yan PY, Ma YP, Wu QB, Leung EL, Plumbagin suppresses non-small cell lung cancer progression through downregulating ARF1 and by elevating CD8+ cells. Pharmacological Research, 2021; 169:105656. (IF=7.658) https://doi.org/10.1016/j.phrs.2021.105656
  29. Deng J,  Han J,  Chen J,  Zhang Y,  Huang Q,  Wang Y,  Qi X,  Liu Z,  Leung EL,  Wang D,  Feng Q,  Lu L, Comparison of analgesic activities of aconitine in different mice pain models. PloS one, 2021; 16(4). https://doi.org/10.1371/journal.pone.0249276
  30. Wang J, Xu C, Chen Y, Shao L, Li T, Fan X, Yu L, Zhang R, Chen B, Chen H, Sui X*, Leung EL*, Wu Q*, β-elemene enhances the antitumor activity of erlotinib by inducing apoptosis through AMPK and MAPK pathways in TKI-resistant H1975 lung cancer cells. Journal of Cancer, 2021; 12(8). https://doi.org/10.7150/jca.53382
  31. Song Q, He X, Xiong Y, Wang J, Zhang L, Leung EL*, Li G*. The functional landscape of Golgi membrane protein 1 (GOLM1) phosphoproteome reveal GOLM1 regulating P53 that promotes malignancy. Cell Death Discovry.2021 Mar 01;71(1), The functional landscape of Golgi membrane protein 1 (GOLM1) phosphoproteome reveal GOLM1 regulating P53 that promotes malignancy. Cell Death Discovery, 2021; 7:42. (IF=5.241) https://doi.org/10.1038/s41420-021-00422-2
  32. Shen C, Weng G, Zhang X, Leung EL, Yao X, Pang J, Chai X, Li D, Wang E, Cao D, Hou T, Accuracy or novelty: what can we gain from target-specific machine-learning-based scoring functions in virtual screening?. Briefings in Bioinformatics, 2021; 22(5):bbaa410. (IF=11.622) https://doi.org/10.1093/bib/bbaa410
  33. Wu Z, Zhu M, Kang Y, Leung EL, Lei T, Shen C, Jiang D, Wang Z, Cao D, Hou T, Do we need different machine learning algorithms for QSAR modeling? A comprehensive assessment of 16 machine learning algorithms on 14 QSAR data sets. Briefings in Bioinformatics, 2021; 22(4):bbaa321. (IF=11.622) https://doi.org/10.1093/bib/bbaa321
  34. Wang Y, Tang S, Lai H, Jin R, Long X, Li N, Tang Y, Guo H, Yao X*, Leung EL*, Discovery of Novel IDH1 Inhibitor Through Comparative Structure-Based Virtual Screening. Frontiers in Pharmacology, 2020; 11:579768. https://doi.org/10.3389/fphar.2020.579768
  35. Jiang ZB, Huang JM, Xie YJ, Zhang YZ, Chan C, Lai HL, Wang WJ, Yao XJ, Fan XX, Wu QB, Xie C, Wang MF*, Leung EL*, Evodiamine suppresses non-small cell lung cancer by elevating CD8+ T cells and downregulating the MUC1-C/PD-L1 axis. Journal of Experimental & Clinical Cancer Research, 2020; 39:249. (IF=7.068) https://doi.org/10.1186/s13046-020-01741-5
  36. Xie Y#, Meng WY#, Li RZ#, Wang YW, Qian X, Chan C, Yu ZF, Fan XX, Pan HD, Xie C, Wu QB, Yan PY, Liu L, Tang YJ, Yao XJ*, Wang MF* and Leung EL*, Early lung cancer diagnostic biomarker discovery by machine learning methods. Translational Oncology, 2020; 14(1):100907. https://doi.org/10.1016/j.tranon.2020.100907
  37. Zhang YZ#, Lai HL#, Chen PP#, Li D, Khan I, Hsiao WL, Fan XX, Yao XJ, Wu QB*, Wang MF* & Leung EL*, Clinical significance of LSECtin and its association with PVR in non-small-cell lung cancer patients. Annals of Translational Medicine, 2020; 8(21). https://doi.org/10.21037/atm-20-3665
  38. Lai HL#, Fan XX#, Liu RZ#, Wang YW, Zhang JM, Liu L, Neher E*, Yao XJ* and Leung EL*, Roles of ion fluxes, metabolism, and redox balance in cancer therapy. Antioxidants & Redox Signaling, 2020 Oct 29(ja). (IF=8.401) https://doi.org/10.1089/ars.2020.8125
  39. Liu Y, Wang M, Luo G, Qian X, Wu C, Zhang Y, Chen B, Leung EL*, Tang Y*, Experience of N-acetylcysteine airway management in the successful treatment of one case of critical condition with COVID-19. Medicine, 2020; 99(42). https://doi.org/10.1097/MD.0000000000022577
  40. Leung EL#, Lai HL#, Li RZ, Pan HD, Jiang ZB Li Y, Duan FG, Xu JH, Zhang YZ, Shi AX, Wei CL, Zhang FY, Yao XJ and Liang Liu, Roles of serum amyloid A1 protein isoforms in rheumatoid arthritis. Engineering, 2022; 10:174-182. (IF=6.495) https://doi.org/10.1016/j.eng.2020.08.018
  41. Wu QB*, Yao XJ, Chen HW, Li T, Fan XX, Zhang GL, Yu LL, Chen M, Xu C, Zhang RN, Chen B, Sui XB*, Leung EL*, Long-term aspirin use for primary cancer prevention: An updated systematic review and subgroup meta-analysis of 29 randomized clinical trials. Journal of Cancer, 2020;11(21):6460. https://doi.org/10.7150/jca.49001
  42. Leung EL, Pan HD, Huang YF, Fan XX, Wang WY, He F, Cai J, Zhou H, Liu L, The scientific foundation of Chinese herbal medicine against COVID-19. Engineering, 2020 Oct;610(10). (IF=6.495) https://doi.org/10.1016/j.eng.2020.08.009
  43. Leung EL*, Xu S*, Traditional Chinese Medicine in Cardiovascular Drug Discovery. Pharmacological Research, 2020 Oct 1;160:105168. (IF=5.893) https://doi.org/10.1016/j.phrs.2020.105168
  44. Wang WJ, Mao LF, Lai HL, Wang YW, Jiang ZB, Li W, Huang JM, Xie YJ, Xu C, Liu P, Li YM, Leung EL*, Yao XJ*, Dolutegravir derivative inhibits proliferation and induces apoptosis of non-small cell lung cancer cells via calcium signaling pathway. Pharmacological Research, 2020 Nov 1;161:105129. (IF=5.893) https://doi.org/10.1016/j.phrs.2020.105129
  45. Liu H, Zheng J, Lai HC, Hu B, Zhu L, Leung EL*, Wei H*, Microbiome technology empowers the development of traditional Chinese medicine. Science China-Life Sciences, 2020 Nov;63(11):1759-61. https://doi.org/10.1007/s11427-020-1778-7
  46. Chen B, Zhang RN, Fan X, Wang J, Xu C, An B, Wang Q, Wang J, Leung EL*, Sui X*, Wu Q*, Clinical diagnostic value of long noncoding RNAs in colorectal Cancer: A systernatic review and meta-analysis. Journal of Cancer, 2020;11(18):5518. https://doi.org/10.7150/jca.46358
  47. Hussain S, Xie YJ, Li D, Malik SI, Hou JC, Leung EL*, Fan XX*, Current strategies against COVID-19. Chinese Medicine, 2020 Dec;15(1):1-2. https://doi.org/10.1186/s13020-020-00353-7
  48. Wang Z, Wu W, Guan X, Guo S, Li C, Niu R, Gao J, Jiang M, Bai L, Leung EL, Hou Y, Jiang Z, Bai G, 20 (S)-protopanaxatriol promotes the binding of P53 and DNA to regulate the antitumor network via multiomic analysis. Acta Pharmaceutica Sinica B, 2020 Feb 5. (IF=7.097) https://doi.org/10.1016/j.apsb.2020.01.017
  49. Huang J, Jiang Z, Wang Y, Fan X, Cai J, Yao X, Liu L, Huang J, He J, Xie C, Wu Q*, Cao Y*, Leung EL*, Modulation of gut microbiota to overcome resistance to immune checkpoint blockade in cancer immunotherapy. Current Opinion in Pharmacology, 2020 Oct 1;54:1-0. https://doi.org/10.1016/j.coph.2020.06.004
  50. Luo S, Xu J, Jiang Z, Liu L, Wu Q, Leung EL*, Leung AP*, Artificial Intelligence-Based Collaborative Filtering Method with Ensemble Learning for Personalized Lung Cancer Medicine without Genetic Sequencing. Pharmacological Research, 2020 Oct 1;160:105037. (IF=5.893) https://doi.org/10.1016/j.phrs.2020.105037
  51. Hu B, Ye C, Leung EL, Zhu L, Hu H, Zhang Z, Zheng J, Liu H, Bletilla striata oligosaccharides improve metabolic syndrome through modulation of gut microbiota and intestinal metabolites in high fat diet-fed mice. Pharmacological Research, 2020 Jun 3:104942. (IF=5.893) https://doi.org/10.1016/j.phrs.2020.104942
  52. Xie YJ, Gao WN, Wu QB, Yao XJ, Jiang ZB, Wang YW, Wang WJ, Li W, Hussain S, Liu L, Leung EL*, Fan XX*, Chelidonine Selectively Inhibits the Growth of Gefitinib-resistant Non-small Cell Lung Cancer Cells through the EGFR-AMPK Pathway. Pharmacological Research, 2020 May 25:104934. (IF=5.893) https://doi.org/10.1016/j.phrs.2020.104934
  53. Huang F, Li Y, Leung EL, Liu X, Liu K, Wang Q, Lan Y, Li X, Yu H, Cui L, Luo H, Luo L, A review of therapeutic agents and Chinese herbal medicines against SARS-COV-2 (COVID-19). Pharmacological Research, 2020 May 20:104929. (IF=5.893) https://doi.org/10.1016/j.phrs.2020.104929
  54. Zheng Y, Xiong C, Liu Y, Qian X, Tang Y, Liu L, Leung EL, Wang M, Epidemiological and Clinical Characteristics Analysis of COVID-19 in the Surrounding Areas of Wuhan, Hubei Province in 2020. Pharmacological Research, 2020 Apr 30:104821. (IF=5.893) https://doi.org/10.1016/j.phrs.2020.104821
  55. Song Q, Zhang J, Wu Q, Li G*, Leung EL*, Kanglaite injection plus Fluorouracil-based chemotherapy on the reduction of adverse effects and improvement of clinical effectiveness in patients with advanced malignant tumors of the digestive tract: A meta-analysis of 20 RCTs following the PRISMA guidelines. Medicine, 2020 Apr 1;99(17):e19480. https://doi.org/10.1097/MD.0000000000019480.
  56. You H, Zhang YZ, Lai HL, Li D, Liu YQ, Li RZ, Khan I, Hsiao WW, Duan FG, Fan XX, Yao XJ, Cao YB, Wu QB*, Leung EL*, Wang MF*, Prognostic significance of tumor poliovirus receptor and CTLA4 expression in patients with surgically resected non-small-cell lung cancer. Journal of Cancer Research and Clinical Oncology, 2020 Apr 4:1-0. https://doi.org/10.1007/s00432-020-03189-8
  57. Yan LE, Zhang HY, Wada M, Fang L, Feng J, Zhang WL, Chen Q, Cao YZ, Pinz KG, Chen KH, Petrov JC, Chen X, Leung EL, Fan XX, Senzel L, Jiang X, Ma YP, Targeting two antigens associated with B-all with CD19-CD123 compound CART cell therapy. Stem Cell Reviews and Reports, 2020 Jan 22:1-2. (IF=5.316) https://doi.org/10.1007/s12015-019-09948-6.
  58. Leung EL* & Wu QB*, Association of Dietary Fiber and Yogurt Consumption With Lung Cancer Risk. JAMA Oncology, 2020 May 1;6(5):788-. (IF=24.799) https://doi.org/10.1001/jamaoncol.2020.0261
  59. Xu C, Yao XJ, Li T, Wang J, Sue XB, Leung EL* and Wu QB*, Pretreatment neutrophil-to-lymphocyte ratio is a predictive biomarker for EGFR TKI-treated patients with advanced EGFR-mutant Non-small cell lung cancer. Translational Cancer Research, 2020 Apr 1;9(4):2875-83. https://doi.org/10.21037/tcr.2020.02.28
  60. Fan XX, Xu MZ, Leung EL, Cai J, Yuan Z & Liu L, ROS-Responsive Berberine Polymeric Micelles Effectively Suppressed the Inflammation of Rheumatoid Arthritis by Targeting Mitochondria. Nano-Micro Letters, 2020 Mar;12(1):1-4. (IF=12.264) https://doi.org/10.1007/s40820-020-0410-x
  61. Mok SW, Wong VK, Lo HH, de Seabra Rodrigues Dias IR, Leung EL, Law BY, Liu L, Natural products-based polypharmacological modulation of the peripheral immune system for the treatment of neuropsychiatric disorders. Pharmacology & Therapeutics, 2020 Apr 1;208:107480. (IF=10.557) https://doi.org/10.1016/j.pharmthera.2020.107480
  62. Liu Y, Chen X, Choi YJ, Yang N, Song Z, Snedecor ER, Liang W, Leung EL, Zhang L, Qin C, Chen J, GORAB promotes embryonic lung maturation through antagonizing AKT phosphorylation, versican expression and mesenchymal cell migration. FASEB Journal, 2020 Apr;34(4):4918-33. https://doi.org/10.1096/fj.201902075R
  63. Chen H, Yao X, Li T, Lam CW, Zhang R, Zhang H, Wang J, Zhang W, Leung EL*, Wu Q*, Compound Kushen injection combined with platinumbased chemotherapy for stage III/IV non-small cell lung cancer: A meta-analysis of 37 RCTs following the PRISMA guidelines. Journal of Cancer, 2020;11(7):1883. https://doi.org/10.7150/jca.40267
  64. Leung EL* & Wu QB*, Commentary on Ge et al. “Insomania and risk of mortality form all-cause, cardiovascular disease, and cancer: Systematic review and meta-analysis of prospective cohort studies. Sleep Medicine Reviews, 2020 Jan 8;50:101257. (IF=10.517) https://doi.org/10.1016/j.smrv.2019.101257
  65. Li JX, Huang JM, Jiang ZB, Li RZ, Sun A, Leung EL* & Yan PY*, Current clinical progress of PD-1/PD-L1 immunotherapy and potential combination treatment in non-small cell lung cancer. Integrative Cancer Therapies, 2019 Dec;18:1534735419890020. https://doi.org/10.1177/1534735419890020
  66. Ren T#, Fan XX#, Wang MF#, Duan FG, Wei CL, Li RZ, Jiang ZB, Wang YW, Yao XJ, Chen MW, Tang YJ*, Leung EL*, miR‑20b promotes growth of non‑small cell lung cancer through a positive feedback loop of the Wnt/β‑catenin signaling pathway. International Journal of Oncology, 2020 Feb 1;56(2):470-9. https://doi.org/10.3892/ijo.2019.4940
  67. Chen H#, Yao X#, Li T, Lam CW, Zhang H, Wang J, Zhang W, Leung EL*, Wu Q*, Compound Kushen injection plus platinum-based chemotherapy for stage IIIB/IV non-small cell lung cancer: A protocol for meta-analysis of randomized clinical trials following the PRISMA guidelines. Medicine, 2019 Dec;98(52). https://doi.org/10.1097/MD.0000000000018552
  68. Leung EL* & Wu QB*, The evidence strength of a meta-analysis of aspirin for primary prevention of cancer. Journal of Cancer Research and Clinical Oncology, 2020 Aug;146(8):2173-5. https://doi.org/10.1007/s00432-019-03069-w
  69. Duan FG#, Wang MF#, Cao YB, Dan Li, Li RZ, Fan XX, Khan I, Lai HL, Zhang YZ, Hsiao WW, Yao XJ, Wu QB, Liu L*, Tang YJ*, Leung EL*, MicroRNA-421 confers paclitaxel resistance by binding to the KEAP1 3’UTR and predicts poor survival in non-small cell lung cancer. Cell Death & Disease, 2019 Oct 28;10(11):1-4. (IF=5.959) https://doi.org/10.1038/s41419-019-2031-1
  70. Wang Y#, Tang C#, Yao S, Lai H, Li R, Xu J, Wang Q, Fan XX, Wu QB, Leung EL*, Ye Y*, Yao X*, Discovery of a novel protein kinase C activator from Croton tiglium for inhibition of non-small cell lung cancer. Phytomedicine, 2019 Dec 1;65:153100. https://doi.org/10.1016/j.phymed.2019.153100
  71. Chen H#, Yao X#, Liu Z#, Li T, Xu C, Wang J, Sui X*, Leung EL*, Wu Q*, Efficacy and safety of Shenqi Fuzheng injection combined with platinum-based chemotherapy for stage III/IV non-small cell lung cancer: A protocol for systematic review and meta-analysis of randomized controlled trials. Medicine, 2019 Sep;98(39). https://doi.org/10.1097/MD.0000000000017350
  72. Wu Q*, Chen H, Yao X, Li T, Xu C, Wang J, Sui X*, Leung EL*, Long-term aspirin use for cancer primary prevention: A protocol for updated systematic review and subgroup meta-analysis of randomized clinical trials. Medicine, 2019 Sep;98(39). https://doi.org/10.1097/MD.0000000000017382
  73. Pan HD#, Xiao Y#, Wang WY, Ren RT, Leung EL* & Liu L*, Traditional Chinese Medicine as a Treatment for Rheumatoid Arthritis-From Empirical Practice to Evidence-based Therapy. Engineering, 2019 Oct 1;5(5):895-906. https://doi.org/10.1016/j.eng.2019.01.018
  74. Zhang J#, Yang C#, Wei D#, Li H#, Leung EL, Deng Q, Liu Z, Fan XX*, Zhang Z*, Long-term efficacy of Chinese medicine Bushen Capsule on cognition and brain activity in patients with amnestic mild cognitive impairment. Pharmacological Research, 2019 Aug 1;146:104319. (IF=5.574) https://doi.org/10.1016/j.phrs.2019.104319
  75. Zhang Y#, Han CY#, Duan FG, Fan XX, Yao XJ, Parks RJ, Tang YJ, Wang MF, Liu L, Tsang BK*, Leung EL*, p53 sensitizes chemoresistant non-small cell lung cancer via elevation of reactive oxygen species and suppression of EGFR/PI3K/AKT signaling. Cancer Cell International, 2019 Dec;19(1):188. https://doi.org/10.1186/s12935-019-0910-2
  76. Pan H, Guo R, Ju Y, Wang Q, Zhu J, Xie Y, Zheng Y, Li T, Liu Z, Lu L, Li F, Tong B, Xiao L, Xu X, Leung EL, Li R, Yang H, Wang J, Zhou H, Jia H, Liu L, A single bacterium restores the microbiome dysbiosis to protect bones from destruction in a rat model of rheumatoid arthritis. Microbiome, 2019 Dec 1;7(1):107. (IF=10.465) https://doi.org/10.1186/s40168-019-0719-1
  77. Jin N#, Bi A#, Lan X#, Xu J, Wang X, Liu Y, Wang T, Tang S, Zeng H, Chen Z, Tan M, Ai J, Xie H, Zhang T, Liu D, Huang R, Song Y, Leung EL, Yao X, Ding J, Geng M*, Lin SH*, Huang M*, Identification of metabolic vulnerabilities of receptor tyrosine kinases-driven cancer. Nature communications, 2019 Jun 20;10(1):1-5. (IF=11.878) https://doi.org/10.1038/s41467-019-10427-2
  78. Tian G#, Wu C#, Li J#, Liang B#, Zhang F, Fan X, Li Z, Wang Y, Li Z*, Liu D*, Leung EL*, Chen J*, Network pharmacology based investigation into the effect and mechanism of Modified Sijunzi Decoction against the subtypes of chronic atrophic gastritis. Pharmacological Research, 2019 Jun 1;144:158-66. (IF=5.574) https://doi.org/10.1016/j.phrs.2019.04.012
  79. Xu JH#, Wang QQ#, Leung EL#, Li Y, Fan XX, Wu QB*, Yao XJ* & Liu Liang*, Compound C620-0696, a new potent inhibitor targeting BPTF, the chromatin remodeling factor in non-small cell lung cancer. Frontiers of Medicine, 2020 Feb;14(1):60-7. https://doi.org/10.1007/s11684-019-0694-8
  80. Wei CL, Zhang DZ, Cheng JL, Chen X, Fan XX, Xie C, Yao XJ, Wang YW, Jiang ZB, Fu JZ* and Leung EL*, Cordycepin Inhibits Drug-resistance Non-small Cell Lung Cancer Progression by Activating AMPK Signaling Pathway. Pharmacological Research, 2019 Jun 1;144:79-89. (IF=5.574) https://doi.org/10.1016/j.phrs.2019.03.011
  81. Leung EL#, Luo LX#, Li Y, Liu ZQ, Li LL, Shi DF, Xie Y, Huang M, Lu LL, Duan FG, Huang JM, Fan XX, Yuan ZW, Ding J, Yao XJ*, Ward DC* & Liu L* , Identification of a new inhibitor of KRAS-PDEδ interaction targeting KRAS mutant non-small cell lung cancer. International journal of cancer, 2019 Sep 1;145(5):1334-45. https://doi.org/10.1002/ijc.32222
  82. Leung EL* & Wu QB*, Concurrent use of herbal products with prescription drugs is a double-edged sword and evidence-based medicine contributes to reshaping the practice. Pharmacological Research, 2017;2:101-7. (IF=5.574) https://doi.org/10.1016/j.phrs.2019.01.033
  83. Wang QQ, An X, Wang YW, Liu L*, Leung EL* and Yao XJ*, Classical molecular dynamics and metadynamics simulations decipher the mechanism of CBP30 selectively inhibiting CBP/p300 bromodomains. Organic & biomolecular chemistry, 2018;16(35):6521-30. https://doi.org/10.1039/c8ob01526k
  84. Fan XX#, Pan HD#, Li Y, Guo RJ, Leung EL*, Liu L*, Novel therapeutic strategy for cancer and autoimmune conditions: Modulating cell metabolism and redox capacity. Pharmacology & therapeutics, 2018 Nov 1;191:148-61. (IF=10.376) https://doi.org/10.1016/j.pharmthera.2018.06.010
  85. Wang Q, Li Y, Xu J, Wang Y, Shi D, Liu L*, Leung EL*, Yao X*, Computational study on the selective inhibition mechanism of MS402 to the first and second bromodomains of BRD4. Proteins-Structure Function and Bioinformatics, 2019 Jan;87(1):3-11. https://doi.org/10.1002/prot.25611
  86. Lai HL, Wang YW, Li Y, Jiang ZB, Duan FG, Luo LX, Liu L*, Leung EL* and Yao XJ*, Krukovine suppresses KRAS-mutated lung cancer cell growth and proliferation by inhibiting the RAF-ERK pathway and inactivating AKT. Frontiers in Pharmacology, 2018 Aug 22;9:958. https://doi.org/10.3389/fphar.2018.00958
  87. Wang YW, Lai HL, Fan XX, Luo LX, Duan FG, Jiang ZB, Wang QQ, Leung EL*, Liu L*, Yao XJ*, Gossypol inhibits non-small cell lung cancer cells proliferation by targeting EGFRL858R/T790M. Frontiers in Pharmacology, 2018 Jul 9;9:728. https://doi.org/10.3389/fphar.2018.00728
  88. Li RZ, Fan XX, Shi DF, Zhu GY, Wang YW, Luo LX, Pan HD, Yao XJ*, Leung EL* & Liu L*, Identification of a new Pyruvate kinase M2 isoform (PKM2) activator for the treatment of non-small cell lung cancer (NSCLC). Chemical Biology & Drug Design, 2018 Nov;92(5):1851-8. https://doi.org/10.1111/cbdd.13354
  89. Li RZ#, Fan XX#, Duan FG, Jiang ZB, Pan HD, Luo LX, Zhou YL, Li Y, Yao YJ, Leung EL* & Liu L*, Proscillaridin A induces apoptosis and suppresses non-small cell lung cancer tumor growth via calcium-induced DR4 up-regulation. Cell Death & Disease, 2018 Jun 13;9(6):1-4. (IF=5.638) https://doi.org/10.1038/s41419-018-0733-4
  90. Wei C, Yang L, Cheng J, Imani S, Fu S, Lv H, Li Y, Chen R, Leung EL*, Fu J*, A novel homozygous variant of GPR98 causes usher syndrome type IIC in a consanguineous Chinese family by next generation sequencing. BMC Medical Genetics, 2018 Dec;19(1):1-8. https://doi.org/10.1186/s12881-018-0602-0
  91. Liu XY, Yang KY, Wang MQ, Kwok JS, Zeng X, Yang Z, Xiao XJ, Lau CP, Li Y, Huang ZM, Ba JG, Yim AK, Ouyang CY, Ngai SM, Chan TF, Leung EL, Liu L, Liu ZG, Tsui SKW, High-quality assembly of Dermatophagoides pteronyssinus genome and transcriptome reveals a wide range of novel allergens. Journal of Allergy and Clinical Immunology, 2018 Jun 1;141(6):2268-71. (IF=13.258) https://doi.org/10.1016/j.jaci.2017.11.038
  92. Dai X, Li RZ, Jiang ZB, Wei CL, Luo LX, Yao XJ*, Li GP* & Leung EL*, Honokiol inhibits proliferation, invasion and induces apoptosis through targeting Lyn kinase in human lung adenocarcinoma cells. Frontiers in Pharmacology, 2018 May 28;9:558. https://doi.org/10.3389/fphar.2018.00558
  93. Wang QQ#, Xu JH#, Li Y, Huang JM, Jiang ZB, Wang YW, Liu L*, Leung EL* and Yao XJ*, Identification of a novel protein arginine methyltransferase 5 inhibitor in non-small cell lung cancer by structure-based virtual screening. Frontiers in Pharmacology, 2018 Mar 1;9:173. https://doi.org/10.3389/fphar.2018.00173
  94. Petrov JC, Wada M, Pinz KG, Yan LE, Chen KH, Shuai X, Liu H, Chen X, Leung EL, Salman H, Hagag N, Liu F, Jiang X, Ma Y, Compound CAR T-cells as a double-pronged approach for treating acute myeloid leukemia. Leukemia, 2018 Jun;32(6):1317-26. (IF=11.702) https://doi.org/10.1038/s41375-018-0075-3
  95. Leung EL#, Luo LX#, Liu ZQ, Wong VKW, Lu LL, Xie Y, Zhang N, Qu YQ, Fan XX, Li Y, Huang M, Xiao DK, Huang J, Zhou YL, He JX, Ding J, Yao XJ*, Ward DC*, Liu L*, Inhibition of KRAS-dependent lung cancer cell growth by deltarasin: blockage of autophagy increases its cytotoxicity. Cell Death & Disease, 2018 Feb 13;9(2):1-5. (IF=5.638) https://doi.org/10.1038/s41419-017-0065-9
  96. Fan XX#, Leung EL#, Xie Y, Liu ZQ, Zheng YF, Yao XJ, Lu LL, Wu JL, He JX, Yuan ZW, Fu JJ, Wei CL, Huang J, Xiao DK, Luo LX, Jiang ZB, Zhou YL, Kam RK, Liu L, Suppression of Lipogenesis via Reactive Oxygen Species-AMPK Signaling for Treating Malignant and Proliferative Diseases. Antioxidants & redox signaling (Cover Story), 2018 Feb 10;28(5):339-57. (IF=6.53) https://doi.org/10.1089/ars.2017.7090
  97. Dai X, Li GP, Yang XQ, Wang XY, Wu J, Leung EL*, Effects of Lyn kinase on EGFR signaling pathway in lung adenocarcinoma/Lyn. China Oncology, 2018 Feb 7;28(1):43-9. https://doi.org/10.19401/j.cnki.1007-3639.2018.01.006
  98. Su X, Li T, Liu Z, Huang Q, Liao K, Ren R, Lu L, Qi X, Wang M, Chen J, Zhou H, Leung EL, Pan HD, Liu J, Wang H, Huang L, Liu L, Licochalcone A activates Keap1-Nrf2 signaling to suppress arthritis via phosphorylation of p62 at serine 349. Free Radical Biology and Medicine, 2018 Feb 1;115:471-83. (IF=6.02) https://doi.org/10.1016/j.freeradbiomed.2017.12.004
  99. Lv S, Ji L, Chen B, Liu S, Lei C, Liu X, Qi X, Wang Y, Leung EL, Wang H, Zhang L, Yu X, Liu Z, Wei Q, Lu L, Histone methyltransferase KMT2D sustains prostate carcinogenesis and metastasis via epigenetically activating LIFR and KLF4. Oncogene, 2018 Mar;37(10):1354-68. (IF=7.519) https://doi.org/10.1038/s41388-017-0026-x
  100. Pinz K, Yakaboski E, Jares A, Liu H, Firor A, Chen K, Wada M, Salman H, Tse W, Hagag N, Lan FS, Leung EL, Jiang S, Ma YP, Targeting T-cell malignancies using anti-CD4 CAR NK-92 cells. Oncotarget, 2017 Dec 22;8(68):112783. (IF=5.168) https://doi.org/10.18632/oncotarget.22626
  101. Li Y#, Leung EL#, Pan HD, Yao XJ, Huang QC, Wu M, Xu T, Wang YW, Cai J, Li RZ, W Liu, Liu L*, Identification of potential genetic causal variants for rheumatoid arthritis by whole-exome sequencing. Oncotarget, 2017 Dec 19;8(67):111119. (IF=5.168) https://doi.org/10.18632/oncotarget.22630
  102. Xie C#, Li Y#, Li LL, Fan XX, Wang YW, Wei CL, Liu L*, Leung EL*, Yao XJ*, Identification of a New Potent Inhibitor Targeting KRAS in Non-small Cell Lung Cancer Cells. Frontiers in Pharmacology, 2017 Nov 14;8:823. https://doi.org/10.3389/fphar.2017.00823
  103. Zhou H, Liu JX, Luo JF, Cheng CS, Leung EL, Li Y, Su XH, Liu ZQ, Chen TB, Duan FG, Dong Y, Zuo YH, Li C, Lio CK, Li T, Luo P, Xie Y, Yao XJ, Wang PX, Liu L, Suppressing mPGES-1 expression by sinomenine ameliorates inflammation and arthritis. Biochemical Pharmacology, 2017 Oct 15;142:133-44. https://doi.org/10.1016/j.bcp.2017.07.010
  104. Chen X, Xie C, Fan XX, Jiang ZB, Wong VKB, Xu JH, Yao XJ*, Liu L*, Leung EL*, Novel direct AMPK activator suppresses non-small cell lung cancer through inhibition of lipid metabolism. Oncotarget, 2017 Nov 10;8(56):96089. (IF=5.168) https://doi.org/10.18632/oncotarget.21716
  105. Chen KH, Wada M, Pinz KG, Liu H, Shuai X, Chen X, Yan LE, Petrov JC, Salman H, Senzel L, Leung EL, Jiang X and Ma YP, A compound chimeric antigen receptor strategy for targeting multiple myeloma. Leukemia, 2018 Feb;32(2):402-12. (IF=10.023) https://doi.org/10.1038/leu.2017.302
  106. Wang QQ, Li Y, Xu JH, Wang YW, Leung EL*, Liu L*, Yao XJ*, Selective inhibition mechanism of RVX-208 to the second bromodomain of bromo and extraterminal proteins: insight from microsecond molecular dynamics simulations. Scientific Reports, 2017 Aug 18;7(1):1-1. https://doi.org/10.1038/s41598-017-08909-8
  107. Zhao L, Leung EL, Wang J, Li H, Che J, Liu L, Yao X*, Cao B*, Association between Charlson comorbidity index score and outcome in patients with stage IIIB-IV non-small cell lung cancer. BMC Pulmonary Medicine, 2017 Dec 1;17(1):112. https://doi.org/10.1186/s12890-017-0452-0
  108. Luo LX, Li Y, Niu YZ, Fan XX, Xu JH, Liu L*, Leung EL*, Yao XJ*, Identification of a potent kinase inhibitor targeting EML4-ALK fusion protein in non-small cell lung cancer. MedChemComm, 2017;8(10):1914-8. https://doi.org/10.1039/c7md00305f
  109. Wong VKW, Zeng W, Chen J, Yao XJ, Leung EL, Wang QQ, Chiu P, Ko BCB, Law BYK, Tetrandrine, an Activator of Autophagy, Induces Autophagic Cell Death via PKC-α Inhibition and mTOR-Dependent Mechanisms. Frontiers in Pharmacology, 2017 Jun 8;8:351. https://doi.org/10.3389/fphar.2017.00351
  110. Li XG, Tang S, Wang QQ, Leung EL, Jin HY, Huang YZ, Liu J, Geng MY, Huang M, Yuan ST, Yao XJ, Ding J, Identification of Epigallocatechin-3- Gallate as an Inhibitor of Phosphoglycerate Mutase 1. Frontiers in Pharmacology, 2017 May 30;8:325. https://doi.org/10.3389/fphar.2017.00325
  111. Luo LX, Li Y, Liu ZQ, Fan XX, Duan FG, Li RZ, Yao XJ*, Leung EL*, Liu L*, Honokiol Induces Apoptosis, G1 Arrest, and Autophagy in KRAS Mutant Lung Cancer Cells. Frontiers in Pharmacology, 2017 Apr 11;8:199. https://doi.org/10.3389/fphar.2017.00199
  112. Yang N, Leung EL, Liu CB, Li L, Eguether T, Yao XJ, Jones E, Norris D, Liu A, Clark R, Roop DR, Pazour GJ, Shroyer KR, Chen J, INTU is essential for oncogenic Hh signaling through regulating primary cilia formation in basal cell carcinoma. Oncogene, 2017 Aug;36(35):4997-5005. (IF=7.519) https://doi.org/10.1038/onc.2017.117
  113. Zong XX, Yan G Y, Wu JL, Leung EL, Zhou H, Li N, Liu L, New C 19 -diterpenoid alkaloids from the parent roots of Aconitum carmichaelii. Tetrahedron Letters, 2017 Apr 19;58(16):1622-6. https://doi.org/10.1016/j.tetlet.2017.03.033
  114. Luo LX, Fan XX, Li Y, Peng X, Ji YC, Hsiao WW, Liu L*, Leung EL*, XJ* Yao, Identification of mitoxantrone as a new inhibitor of ROS1 fusion protein in non-small cell lung cancer cells. MedChemComm, 2017;8(3):621-4. https://doi.org/10.1039/C6MD00643D
  115. Law BY, Gordillo-Martínez F, Qu YQ, Zhang N, Xu SW, Saul Coghi P, Mok SW, Guo JR, Zhang W, Leung EL, Fan XX, Wu AG, Chan WK, Yao XJ, Wang JR, Liu L, Wong VK, Thalidezine, a novel AMPK activator, eliminates apoptosis-resistant cancer cells through energy-mediated autophagic cell death. Oncotarget, 2017 May 2;8(18):30077. (IF=5.168) https://doi.org/10.18632/oncotarget.15616
  116. Chen K, Wada M, Pinz K, Liu H, Lin KW, Jares A, Firor A, Shuai X, Salman H, Golightly M, Lan FS, Senzel L, Leung EL, X Jiang, Ma YP, Preclinical targeting of aggressive T-cell malignancies using anti-CD5 chimeric antigen receptor. Leukemia, 2017 Oct;31(10):2151-60. (IF=11.702) https://doi.org/10.1038/leu.2017.8
  117. Liang Y, Wu JL, Li X, Guo MQ, Leung EL, Zhou H, Liu L, Li N, Anti-cancer and anti-inflammatory new vakognavine-type alkaloid from the roots of Aconitum carmichaelii. Tetrahedron Letters, 2016 Dec 28;57(52):5881-4. https://doi.org/10.1016/j.tetlet.2016.11.065
  118. Leung EL, Clementi E, Wong WS, Advanced technologies charting a new path for traditional Chinese medicine drug discovery. Pharmacological Research, 2017 Mar;117:65. https://doi.org/10.1016/j.phrs.2016.12.010
  119. Li X#, Fan XX#, Jiang ZB, Loo WTY, Yao XJ, Leung EL*, Chow LWC*, Liu L*, Shikonin inhibits gefitinib-resistant non-small cell lung cancer by inhibiting TrxR and activating the EGFR proteasomal degradation pathway. Pharmacological Research, 2017 Jan 1;115:45-55. https://doi.org/10.1016/j.phrs.2016.11.011
  120. Yu J, Zhang Y, Leung EL, Liu L, Yang F, Yao X, Efficacy and safety of angiogenesis inhibitors in advanced gastric cancer: a systematic review and meta-analysis. Journal of Hematology & Oncology, 2016 Dec 1;9(1):111. (IF=6.263) https://doi.org/10.1186/s13045-016-0340-8
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  122. Wang MF#, Li RZ#, Li Y, Cheng XQ, Yang J, Chen W, Fan XX, Pan HD, Yao XJ, RT XQ, Liu L*, Leung EL*, Tang YJ*, Clinical statistics analysis on the characteristics of pneumoconiosis of Chinese miner population. Journal of Thoracic Disease, 2016 Aug;8(8):2203. https://doi.org/10.21037/jtd.2016.07.53
  123. Xu SW, Law BY, Mok SW, Leung EL, Fan XX, Coghi PS, Zeng W, Leung CH, Ma DL, Liu L, Wong VKB, Autophagic degradation of epidermal growth factor receptor in gefitinib-resistant lung cancer by celastrol. International Journal of Oncology, 2016 Oct 1;49(4):1576-88. https://doi.org/10.3892/ijo.2016.3644
  124. Chan CM, Chu H, Zhang AJ, Leung EL, Sze KH, Kao RY, Chik KK, To KK, Chan JW, Chen H, Jin DY, L Liu, Yuen KY*, Hemagglutinin of influenza A virus binds specifically to cell surface nucleolin and plays a role in virus internalization. Virology, 2016 Jul 1;494:78-88. https://doi.org/10.1016/j.virol.2016.04.008
  125. Huang J#, Fan XX#, He JX#, Pan H, Li RZ, Huang LY, Jiang ZB, Yao XJ, Liu L, Leung EL*, He JX*, SCD1 is associated with tumor promotion, late stage and poor survival in lung adenocarcinoma. Oncotarget, 2016 Jun 28;7(26):39970. (IF=5.008) https://doi.org/10.18632/oncotarget.9461
  126. Jiang ZB#, Huang J#, Xie C, Li X, Liu L, He J, Pan H, Huang L, Fan XX, Yao XJ, Xie Y, Li N, Liu L, He JX*, Leung EL*, Combined use of PI3K and MEK inhibitors synergistically inhibits lung cancer with EGFR and KRAS mutations. Oncology reports, 2016 Jul 1;36(1):365-75. https://doi.org/10.3892/or.2016.4770
  127. Liang Y, Wu JL, Leung EL, Zhou H, Liu ZQ, Yan GY, Liu Y, Liu L*, Li N*, Identification of Oxygenated Fatty Acid as a Side Chain of Lipo-Alkaloids in Aconitum carmichaelii by UHPLC-Q-TOF-MS and a Database. Molecules, 2016 Apr;21(4):437. https://doi.org/10.3390/molecules21040437
  128. Zhang YZ#, Chen X#, Fan XX, He JX, Huang J, Xiao DK, Zhou YL, Zheng SY, Xu JH, Yao XJ, Liu L*, Leung EL*, Compound Library Screening Identified Cardiac Glycoside Digitoxin as an Effective Growth Inhibitor of Gefitinib-Resistant Non-Small Cell Lung Cancer via Downregulation of alpha-Tubulin and Inhibition of Microtubule Formation. Molecules, 2016 Mar;21(3):374. https://doi.org/10.3390/molecules21030374
  129. Leung EL, Fan XX, Wong MP, Jiang ZH, Liu ZQ, Yao XJ, Lu LL, Zhou YL, Yau LF, Tin PC, Liu L, Targeting Tyrosine Kinase Inhibitor-Resistant Non-Small Cell Lung Cancer by Inducing Epidermal Growth Factor Receptor Degradation via Methionine 790 Oxidation. Antioxidants & Redox Signaling (Cover story), 2016 Feb 10;24(5):263-79. (IF=7.093) https://doi.org/10.1089/ars.2015.6420
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  131. Lu LL, Liu XH, Leung EL, Wang Y, Shi J, Hu M, Liu L, Liu ZQ, The bioavailability barrier and personalized traditional Chinese medicine. Science, 2015;350(6262):S79-81. (IF=33.611)
  132. Fan XX, Yao XJ, Xu SW, Wong VK, He JX, Ding J, Xue WW, Mujtaba T, Michelangeli F, Huang M, Huang J, Xiao DK, Jiang ZB, Zhou YL, Kam RK, Liu L*, Leung EL*, (Z)3,4,5,4′-trans-tetramethoxystilbene, a new analogue of resveratrol, inhibits gefitinb-resistant non-small cell lung cancer via selectively elevating intracellular calcium level. Scientific Reports, 2015 Nov 6;5:16348. (IF=5.578) https://doi.org/10.1038/srep16348
  133. Yuan ZW, Leung EL, Fan XX, Ma WZ, Liu L, Xie Y, Quantitative evaluation of berberine subcellular distribution and cellular accumulation in non-small cell lung cancer cells by UPLC-MS/MS. Talanta, 2015 Nov 1;144:20-8. https://doi.org/10.1016/j.talanta.2015.05.017
  134. Li T, Wong VK, Jiang ZH, Jiang SP, Liu Y, Wang TY, Yao XJ, Su XH, Yan FG, Liu J, Leung EL, Yi XQ, Wong YF, Zhou H, Liu L, Mutation of cysteine 46 in IKK-beta increases inflammatory responses. Oncotarget, 2015 Oct 13;6(31):31805. (IF=6.359) https://doi.org/10.18632/oncotarget.5567
  135. Gu WY, Li N, Leung EL, Zhou H, Yao XJ, Liu L, Wu JL, Rapid identification of new minor chemical constituents from Smilacis Glabrae Rhizoma by combined use of UHPLC-Q-TOF-MS, preparative HPLC and UHPLC-SPE-NMR-MS techniques. Phytochemical Analysis, 2015 Nov;26(6):428-35. https://doi.org/10.1002/pca.2577
  136. Liu L, Liu L, Leung EL, Cooney AJ, Chen C, Rosengart TK, Ma YP, Yang JC, Knockdown of SALL4 Protein Enhances All-trans Retinoic Acid-induced Cellular Differentiation in Acute Myeloid Leukemia Cells. Journal of Biological Chemistry, 2015 Apr 24;290(17):10599-609. https://doi.org/10.1074/jbc.M114.634790
  137. Wang R, Zhang CY, Bai LP, Pan HD, Shu LM, Kong AN, Leung EL, Liu L, Li T, Flavonoids derived from liquorice suppress murine macrophage activation by up-regulating heme oxygenase-1 independent of Nrf2 activation. International Immunopharmacology, 2015 Oct 1;28(2):917-24. https://doi.org/10.1016/j.intimp.2015.03.040
  138. Gu WY, Li N*, Leung EL, Zhou H, Luo GA, L Liu, Wu JL*, Metabolites software-assisted flavonoid hunting in plants using ultra-high performance liquid chromatography-quadrupole-time of flight mass spectrometry. Molecules, 2015 Mar;20(3):3955-71. https://doi.org/10.3390/molecules20033955
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  141. Fan XX, Li N, Wu JL, Zhou YL, He JX, Liu L, Leung EL*, Celastrol induces apoptosis in gefitinib-resistant non-small cell lung cancer cells via caspases-dependent pathways and Hsp90 client protein degradation. Molecules, 2014 Mar;19(3):3508-22. https://doi.org/10.3390/molecules19033508
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  148. Leung EL, Wong JC, Johlfs MG, Tsang BK, Fiscus RR, Protein kinase G type Ialpha activity in human ovarian cancer cells significantly contributes to enhanced Src activation and DNA synthesis/cell proliferation. Molecular Cancer Research, 2010 Apr 1;8(4):578-91. https://doi.org/10.1158/1541-7786.MCR-09-0178
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