* Visit https://www.scopus.com/authid/detail.uri?authorId=16158950400 to check the most up-to-date publication.
- Ju, Y., Tam, K.Y. (2020) 9R, the cholinesterase and amyloid beta aggregation dual inhibitor, as a multifunctional agent to improve cognitive deficit and neuropathology in the triple-transgenic Alzheimer’s disease mouse model. Neuropharmacology 181
- Ju, Y., Chakravarty, H., Tam, K.Y. (2020) An Isoquinolinium Dual Inhibitor of Cholinesterases and Amyloid β Aggregation Mitigates Neuropathological Changes in a Triple-Transgenic Mouse Model of Alzheimer’s Disease. ACS Chemical Neuroscience 11 (20): 3346 – 3357
- Hong, X.-Q., He, X.-Y., Tam, K.Y., Chen, W.-H. (2020) Synthesis and biological effect of lysosome-targeting fluorescent anion transporters with enhanced anionophoric activity. Bioorganic and Medicinal Chemistry Letters 30 (19)
- Xiang, S., Huang, D., He, Q., Li, J., Tam, K.Y., Zhang, S.-L., He, Y. (2020) Development of dual inhibitors targeting pyruvate dehydrogenase kinases and human lactate dehydrogenase A: High-throughput virtual screening, synthesis and biological validation. European Journal of Medicinal Chemistry 203
- Chakravarty, H., Ju, Y., Chen, W.-H., Tam, K.Y. (2020) Dual targeting of cholinesterase and amyloid beta with pyridinium/isoquinolium derivatives. Drug Development Research 81 (2): 242 – 255
- Yang, Z., Chan, K.I., Kwok, H.F., Tam, K.Y. (2019) Novel Therapeutic Anti-ADAM17 Antibody A9(B8) Enhances EGFR-TKI–Mediated Anticancer Activity in NSCLC. Translational Oncology 12 (11): 1516 – 1524
- Cui, M., Ying, R., Jiang, X., Li, G., Zhang, X., Zheng, J., Tam, K.Y., Liang, B., Shi, A., Göbel, V., Zhang, H. (2019) A Model of Hereditary Sensory and Autonomic Neuropathy Type 1 Reveals a Role of Glycosphingolipids in Neuronal Polarity. The Journal of neuroscience : the official journal of the Society for Neuroscience 39 (29): 5816 – 5834
- Verma, A., Lam, Y.-M., Leung, Y.-C., Hu, X., Chen, X., Cheung, E., Tam, K.Y. (2019) Combined use of arginase and dichloroacetate exhibits anti-proliferative effects in triple negative breast cancer cells. Journal of Pharmacy and Pharmacology 71 (3): 306 – 315
- Cheng, X., Jiang, X., Tam, K.Y., Li, G., Zheng, J., Zhang, H. (2019) Sphingolipidomic analysis of c. Elegans reveals development-and environment-dependent metabolic features. International Journal of Biological Sciences 15 (13): 2897 – 2910
- Yu, X.-H., Cai, X.-J., Hong, X.-Q., Tam, K.Y., Zhang, K., Chen, W.-H. (2019) Synthesis and biological evaluation of aza-crown ether-squaramide conjugates as anion/cation symporters. Future Medicinal Chemistry 11 (10): 1091 – 1106
- Wu, X., Kosaraju, J., Tam, K.Y. (2018) Anti-neuroinflammatory effects of SLOH in Aβ-induced BV-2 microglial cells and 3xTg-AD mice involve the inhibition of GSK-3β. Neuroscience Letters 687: 207 – 215
- Zhang, S.-L., Yang, Z., Hu, X., Tam, K.Y. (2018) Dichloroacetophenones targeting at pyruvate dehydrogenase kinase 1 with improved selectivity and antiproliferative activity: Synthesis and structure-activity relationships. Bioorganic and Medicinal Chemistry Letters 28 (21): 3441 – 3445
- Zhang, W., Hu, X., Chakravarty, H., Yang, Z., Tam, K.Y. (2018) Identification of Novel Pyruvate Dehydrogenase Kinase 1 (PDK1) Inhibitors by Kinase Activity-Based High-Throughput Screening for Anticancer Therapeutics. ACS Combinatorial Science 20 (11): 660 – 671
- Yang, Z., Zhang, S.-L., Hu, X., Tam, K.Y. (2018) Inhibition of pyruvate dehydrogenase kinase 1 enhances the anti-cancer effect of EGFR tyrosine kinase inhibitors in non-small cell lung cancer. European Journal of Pharmacology 838: 41 – 52
- Tam, K., Li, T., Mandić, Z. (2018) Editorial, IAPC-6 Meeting. Pharmaceutical Research 35 (11)
- Zhang, S.-L., Yang, Z., Hu, X., Chakravarty, H., Tam, K.Y. (2018) Anticancer effects of some novel dichloroacetophenones through the inhibition of pyruvate dehydrogenase kinase 1. European Journal of Pharmaceutical Sciences 123: 43 – 55
- Zhang, W., Hu, X., Zhou, W., Tam, K.Y. (2018) Liquid Chromatography-Tandem Mass Spectrometry Method Revealed that Lung Cancer Cells Exhibited Distinct Metabolite Profiles upon the Treatment with Different Pyruvate Dehydrogenase Kinase Inhibitors. Journal of Proteome Research 17 (9): 3012 – 3021
- Wang, X.X., Li, Z.Y., Tian, Y., Wang, W., Pang, Y., Tam, K.Y. (2018) Two dimensional photoacoustic imaging using microfiber interferometric acoustic transducers. Optics Communications 419: 41 – 46
- Zhang, S.-L., He, Y., Tam, K.Y. (2018) Targeting cancer metabolism to develop human lactate dehydrogenase (hLDH)5 inhibitors. Drug Discovery Today 23 (7): 1407 – 1415
- Lyu, J., Yang, E.J., Head, S.A., Ai, N., Zhang, B., Wu, C., Li, R.-J., Liu, Y., Chakravarty, H., Zhang, S., Tam, K.Y., Dang, Y., Kwon, H.J., Ge, W., Liu, J.O., Shim, J.S. (2018) Astemizole inhibits mTOR signaling and angiogenesis by blocking cholesterol trafficking. International Journal of Biological Sciences 14 (10): 1175 – 1185
- Hu, J., Tan, S.K., Lim, M.G.L., Chang, S.H., Cui, G., Liu, S., Narasimhan, K., New, S.Y., Wang, X., Chen, C., Chakravarty, H., Kolatkar, P.R., Tam, K.Y., Lu, Q., Su, X., Jauch, R., Cheung, E. (2018) Identification of a Wells-Dawson polyoxometalatebased AP-2γ inhibitor with pro-apoptotic activity. Biochemical Journal 475 (11): 1965 – 1977
- Tian, Y., Xu, W., Zhang, H., Tam, K.Y., Zhang, H., Yang, L., Li, Z., Pang, Y. (2018) The scalp time-varying networks of N170: Reference, latency, and information flow. Frontiers in Neuroscience 12 (APR)
- Wu, X., Kosaraju, J., Zhou, W., Tam, K.Y. (2018) SLOH, a carbazole-based fluorophore, mitigates neuropathology and behavioral impairment in the triple-transgenic mouse model of Alzheimer’s disease. Neuropharmacology 131: 351 – 363
- Tam, K., Mandić, Z. (2018) Special issue devoted to the 6th IAPC meeting: Joint events comprising 6th world conference on physico-chemical methods in drug discovery and development and 3rd world conference on ADMET and DMPK. ADMET and DMPK 6 (1): 1 – 3
- Yang, Z., Tam, K.Y. (2018) Combination strategies using EGFR-TKi in NSCLC therapy: Learning from the gap between pre-clinical results and clinical outcomes. International Journal of Biological Sciences 14 (2): 204 – 216
- Mandić, Z., Tam, K. (2017) Editorial, IAPC-5 Special Issue. European Journal of Pharmaceutical Sciences 110: 1 –
- Wu, X., Kosaraju, J., Tam, K.Y. (2017) SLM, a novel carbazole-based fluorophore attenuates okadaic acid-induced tau hyperphosphorylation via down-regulating GSK-3β activity in SH-SY5Y cells. European Journal of Pharmaceutical Sciences 110: 101 – 108
- Zhang, W., Zhang, S.-L., Hu, X., Tam, K.Y. (2017) Phenyl butyrate inhibits pyruvate dehydrogenase kinase 1 and contributes to its anti-cancer effect. European Journal of Pharmaceutical Sciences 110: 93 – 100
- Zhang, S.-L., Zhang, W., Yang, Z., Hu, X., Tam, K.Y. (2017) Synthesis and biological evaluation of (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionamides as pyruvate dehydrogenase kinase 1 (PDK1) inhibitors to reduce the growth of cancer cells. European Journal of Pharmaceutical Sciences 110: 87 – 92
- Guo, L.X., Liu, J.H., Zheng, X.X., Yin, Z.Y., Kosaraju, J., Tam, K.Y. (2017) Geniposide improves insulin production and reduces apoptosis in high glucose-induced glucotoxic insulinoma cells. European Journal of Pharmaceutical Sciences 110: 70 – 76
- Zhou, W., Hu, X., Tam, K.Y. (2017) Systemic clearance and brain distribution of carbazole-based cyanine compounds as Alzheimer’s disease drug candidates. Scientific Reports 7 (1)
- Yang, Z., Hu, X., Zhang, S., Zhang, W., Tam, K.Y. (2017) Pharmacological synergism of 2,2-dichloroacetophenone and EGFR-TKi to overcome TKi-induced resistance in NSCLC cells. European Journal of Pharmacology 815: 80 – 87
- Kosaraju, J., Holsinger, R.M.D., Guo, L., Tam, K.Y. (2017) Linagliptin, a Dipeptidyl Peptidase-4 Inhibitor, Mitigates Cognitive Deficits and Pathology in the 3xTg-AD Mouse Model of Alzheimer’s Disease. Molecular Neurobiology 54 (8): 6074 – 6084
- Tian, Y., Yang, L., Chen, S., Guo, D., Ding, Z., Tam, K.Y., Yao, D. (2017) Causal interactions in resting-state networks predict perceived loneliness. PLoS ONE 12 (5)
- Wu, X., Kosaraju, J., Zhou, W., Tam, K.Y. (2017) Neuroprotective Effect of SLM, a Novel Carbazole-Based Fluorophore, on SH-SY5Y Cell Model and 3xTg-AD Mouse Model of Alzheimer’s Disease. ACS Chemical Neuroscience 8 (3): 676 – 685
- Hu, X., Tam, K.Y. (2017) Association of vancomycin with lipid vesicles. ADMET and DMPK 5 (3): 182 – 191
- Hu, X., Tam, K. (2017) Biomembrane mimics and their roles in anti-bacterial drug discovery. ADMET and DMPK 5 (1): 9 – 13
- Peters, G.J., Tam, K. (2016) ADME/DMPK in the development and use of tyrosine and serine-threonine kinase inhibitors. ADMET and DMPK 4 (3): 182 – 185
- Peng, X.-M., Peng, L.-P., Li, S., Avula, S.R., Kannekanti, V.K., Zhang, S.-L., Tam, K.Y., Zhou, C.-H. (2016) Quinazolinone azolyl ethanols: Potential lead antimicrobial agents with dual action modes targeting methicillin-resistant Staphylococcus aureus DNA. Future Medicinal Chemistry 8 (16): 1927 – 1940
- Xiao, Q., Hu, X., Wei, Z., Tam, K.Y. (2016) Cytoskeleton molecular motors: Structures and their functions in neuron. International Journal of Biological Sciences 12 (9): 1083 – 1092
- Zhang, S.-L., Hu, X., Zhang, W., Tam, K.Y. (2016) Unexpected Discovery of Dichloroacetate Derived Adenosine Triphosphate Competitors Targeting Pyruvate Dehydrogenase Kinase to Inhibit Cancer Proliferation. Journal of Medicinal Chemistry 59 (7): 3562 – 3568
- Zhou, W., Wu, X., Li, J., Hu, X., Tam, K.Y. (2016) Quantification of permanent positively charged compounds in plasma using one-step dilution to reduce matrix effect in MS. Bioanalysis 8 (6): 497 – 509
- Yang, Z., Tam, K.Y. (2016) Anti-cancer synergy of dichloroacetate and EGFR tyrosine kinase inhibitors in NSCLC cell lines. European Journal of Pharmacology 789: 458 – 467
- Zhang, S.-L., Zhang, W., Xiao, Q., Yang, Z., Hu, X., Wei, Z., Tam, K.Y. (2016) Development of dichloroacetamide pyrimidines as pyruvate dehydrogenase kinase inhibitors to reduce cancer cell growth: Synthesis and biological evaluation. RSC Advances 6 (82): 78762 – 78767
- Yin, G., Wang, P., Lang, J., Tian, Y., Luo, Y., Fan, Z., Tam, K.Y. (2016) Dosimetric study for cervix carcinoma treatment using intensity modulated radiation therapy (IMRT) compensation based on 3D intracavitary brachytherapy technique. Journal of Contemporary Brachytherapy 8 (3): 221 – 232
- Zhang, W., Zhang, S.-L., Hu, X., Tam, K.Y. (2015) Targeting tumor metabolism for cancer treatment: Is pyruvate dehydrogenase kinases (PDKs) a viable anticancer target?. International Journal of Biological Sciences 11 (12): 1390 – 1400
- Dohoda, D., Tsinman, K., Tsinman, O., Wang, H., Tam, K.Y. (2015) Spectrophotometric pK<inf>a</inf> determination of ionizable pharmaceuticals: Resolution of molecules with weak pH-dependent spectral shift. Journal of Pharmaceutical and Biomedical Analysis 114: 88 – 96
- Zhang, S.-L., Hu, X., Zhang, W., Yao, H., Tam, K.Y. (2015) Development of pyruvate dehydrogenase kinase inhibitors in medicinal chemistry with particular emphasis as anticancer agents. Drug Discovery Today 20 (9): 1112 – 1119
- Tam, K. (2015) Research in neurodegenerative diseases: Challenges and solutions. ADMET and DMPK 3 (3): 154 –
- Li, J., Zhou, W., Wu, X., Tam, K. (2015) Chemical and physical approaches for the treatment of Alzheimer’s disease. ADMET and DMPK 3 (3): 216 – 234
- Wu, X., Li, J., Zhou, W., Tam, K. (2015) Animal models for Alzheimer’s disease: A focused review of transgenic rodent models and behavioral assessment methods. ADMET and DMPK 3 (3): 242 – 253
- Tian, Y., Ding, Z., Tam, K.Y., Wang, Z., Zhang, H., Zhao, D., Zhao, Y., Xu, W., Zheng, S. (2015) Specific frequency bands of amplitude low-frequency fluctuations in memory-related cognitive impairment: Predicting Alzheimer’s disease. ADMET and DMPK 3 (3): 274 – 280
- Zhou, W., Tam, K.Y., Meng, M., Shan, J., Wang, S., Ju, W., Cai, B., Di, L. (2015) Pharmacokinetics screening for multi-components absorbed in the rat plasma after oral administration of traditional Chinese medicine Flos Lonicerae Japonicae-Fructus Forsythiae herb couple by sequential negative and positive ionization ultra-high-performance liquid chromatography/tandem triple quadrupole mass spectrometric detection. Journal of Chromatography A 1376: 84 – 97
- Jampilek, J., Crowley, P.J., Olsen, M., Tam, K. (2015) Modern approaches to quality assurance of drug formulations. BioMed Research International 2015
- Zhang, S.-L., Yao, H., Wang, C., Tam, K.Y. (2014) Study the interactions between human serum albumin and two antifungal drugs: Fluconazole and its analogue DTP. Bioorganic and Medicinal Chemistry Letters 24 (21): 4963 – 4968
- Velický, M., Rodgers, A.N.J., Dryfe, R.A.W., Tam, K. (2014) Use of voltammetry for in vitro equilibrium and transport studies of ionisable drugs. ADMET and DMPK 2 (3): 143 – 156
- Tam, K., Mandić, Z. (2014) Special issue devoted to the 3rd world conference on physico-chemical methods in drug discovery and development (PCMDDD-3). ADMET and DMPK 2 (1): 1 – 2
- Velický, M., Tam, K.Y., Dryfe, R.A.W. (2014) Mechanism of ion transfer in supported liquid membrane systems: Electrochemical control over membrane distribution. Analytical Chemistry 86 (1): 435 – 442
- Wen, Z., Chenyin, W., Tam, K.Y. (2014) Predicting the minimal inhibitory concentration of fluoroquinolones for Escherichia coli using an accumulation model. Bio-Medical Materials and Engineering 24 (6): 3745 – 3751
- Chenyin, W., Avdeef, A., Wen, Z., Tam, K.Y. (2014) Predicting the human jejunal permeability and fraction absorbed of fluoroquinolones based on a biophysical model. Bio-Medical Materials and Engineering 24 (6): 3849 – 3854
- Tam, K. (2013) One year in circulation – an exciting journey for ADMET & DMPK. ADMET and DMPK 1 (4): 46 – 47
- Tam, K. (2013) Estimating the “first in human” dose – a revisit with particular emphasis on oncology drugs. ADMET and DMPK 1 (4): 63 – 75
- Francine, E., Tsakmaka, C., Mohr, S., Fielden, P.R., Goddard, N.J., Booth, J., Tam, K.Y. (2013) Using droplet-based microfluidic technology to study the precipitation of a poorly water-soluble weakly basic drug upon a pH-shift. Analyst 138 (1): 339 – 345
- Tam, K. (2013) The roles of doxorubicin in hepatocellular carcinoma. ADMET and DMPK 1 (3): 29 – 44
- Foote, K.M., Blades, K., Cronin, A., Fillery, S., Guichard, S.S., Hassall, L., Hickson, I., Jacq, X., Jewsbury, P.J., McGuire, T.M., Nissink, J.W.M., Odedra, R., Page, K., Perkins, P., Suleman, A., Tam, K., Thommes, P., Broadhurst, R., Wood, C. (2013) Discovery of 4-{4-[(3R)-3-methylmorpholin-4-yl]-6-[1-(methylsulfonyl) cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): A potent and selective inhibitor of ATR protein kinase with monotherapy in vivo antitumor activity. Journal of Medicinal Chemistry 56 (5): 2125 – 2138
- Tam, K. (2013) Close relationships between in vitro ADMET and DMPK research in pre-clinical drug discovery. ADMET and DMPK 1 (1): 1 – 2
- Velický, M., Tam, K.Y., Dryfe, R.A.W. (2012) Hydrodynamic voltammetry at the liquid-liquid interface: Application to the transfer of ionised drug molecules. Journal of Electroanalytical Chemistry 683: 94 – 102
- Eblagon, K.M., Tam, K., Tsang, S.C.E. (2012) Comparison of catalytic performance of supported ruthenium and rhodium for hydrogenation of 9-ethylcarbazole for hydrogen storage applications. Energy and Environmental Science 5 (9): 8621 – 8630
- Völgyi, G., Vizserálek, G., Takács-Novák, K., Avdeef, A., Tam, K.Y. (2012) Predicting the exposure and antibacterial activity of fluoroquinolones based on physicochemical properties. European Journal of Pharmaceutical Sciences 47 (1): 21 – 27
- Lee, G.K.-C., Kwok, S.-Y., Hao Yu, C., Tam, K., Chong, H.-C., Leung, Y.-C., Edman Tsang, S.C. (2012) Immobilization of engineered arginase on gold-carbon nanotubes. Chemical Communications 48 (62): 7693 – 7695
- Velický, M., Tam, K.Y., Dryfe, R.A.W. (2012) On the stability of the silver/silver sulfate reference electrode. Analytical Methods 4 (5): 1207 – 1211
- Eblagon, K.M., Tam, K., Yu, K.M.K., Tsang, S.C.E. (2012) Comparative study of catalytic hydrogenation of 9-ethylcarbazole for hydrogen storage over noble metal surfaces. Journal of Physical Chemistry C 116 (13): 7421 – 7429
- Velický, M., Tam, K.Y., Dryfe, R.A.W. (2012) Permeation of a fully ionized species across a polarized supported liquid membrane. Analytical Chemistry 84 (5): 2541 – 2547
- Velický, M., Tam, K.Y., Dryfe, R.A.W. (2011) In situ artificial membrane permeation assay under hydrodynamic control: Correlation between drug in vitro permeability and fraction absorbed in humans. European Journal of Pharmaceutical Sciences 44 (3): 299 – 309
- Tam, K.Y., Leung, K.C.-F., Wang, Y.-X.J. (2011) Chemoembolization agents for cancer treatment. European Journal of Pharmaceutical Sciences 44 (43862): 1 – 10
- Yu, C.H., Tam, K., Tsang, S.C. (2011) A new high-throughput method utilizing porous silica-based nano-composites for the determination of partition coefficients of drug candidates. Journal of Separation Science 34 (18): 2505 – 2512
- Chan, C.W.A., Tam, K.Y., Cookson, J., Bishop, P., Tsang, S.C. (2011) Palladium with interstitial carbon atoms as a catalyst for ultraselective hydrogenation in the liquid phase. Catalysis Science and Technology 1 (9): 1584 – 1592
- Buttar, D., Colclough, N., Gerhardt, S., MacFaul, P.A., Phillips, S.D., Plowright, A., Whittamore, P., Tam, K., Maskos, K., Steinbacher, S., Steuber, H. (2010) A combined spectroscopic and crystallographic approach to probing drug-human serum albumin interactions. Bioorganic and Medicinal Chemistry 18 (21): 7486 – 7496
- Velický, M., Bradley, D.F., Tam, K.Y., Dryfe, R.A.W. (2010) In situ artificial membrane permeation assay under hydrodynamic control: Permeability-ph profiles of warfarin and verapamil. Pharmaceutical Research 27 (8): 1644 – 1658
- Morawa Eblagon, K., Tam, K., Yu, K.M.K., Zhao, S.-L., Gong, X.-Q., He, H., Ye, L., Wang, L.-C., Ramirez-Cuesta, A.J., Tsang, S.C. (2010) Study of catalytic sites on ruthenium for hydrogenation of N-ethylcarbazole: Implications of hydrogen storage via reversible catalytic hydrogenation. Journal of Physical Chemistry C 114 (21): 9720 – 9730
- Avdeef, A., Tam, K.Y. (2010) How well can the caco-2/madin-darby canine kidney models predict effective human jejunal permeability?. Journal of Medicinal Chemistry 53 (9): 3566 – 3584
- Tam, K.Y., Avdeef, A., Tsinman, O., Sun, N. (2010) The permeation of amphoteric drugs through artificial membranes – An in combo absorption model based on paracellular and transmembrane permeability. Journal of Medicinal Chemistry 53 (1): 392 – 401
- Colclough, N., Ruston, L., Tam, K. (2009) Aqueous Solubility in Drug Discovery Chemistry, DMPK, and Biological Assays. Drug Bioavailability: Estimation of Solubility, Permeability, Absorption and Bioavailability 40: 7 – 31
- Lo, C.C.H., Tsang, S.C., Yu, C.H., Tam, K. (2009) Magnetic properties of macroscopic colloid crystals of silica-coated FePt nanoparticles with controllable interstices for molecular separation. Journal of Applied Physics 105 (7)
- Yu, C.H., Al-Saadi, A., Shih, S.-J., Qiu, L., Tam, K.Y., Tsang, S.C. (2009) Immobilization of BSA on silica-coated magnetic iron oxide nanoparticle. Journal of Physical Chemistry C 113 (2): 537 – 543
- Jones, C.D., Andrews, D.M., Barker, A.J., Blades, K., Daunt, P., East, S., Geh, C., Graham, M.A., Johnson, K.M., Loddick, S.A., McFarland, H.M., McGregor, A., Moss, L., Rudge, D.A., Simpson, P.B., Swain, M.L., Tam, K.Y., Tucker, J.A., Walker, M. (2008) The discovery of AZD5597, a potent imidazole pyrimidine amide CDK inhibitor suitable for intravenous dosing. Bioorganic and Medicinal Chemistry Letters 18 (24): 6369 – 6373
- Yu, C.-H., Tam, K., Tsang, E.S.C. (2008) Chapter 5 Chemical Methods for Preparation of Nanoparticles in Solution. Handbook of Metal Physics 5: 113 – 141
- Yu, C.-H., Oduro, W., Tam, K., Tsang, E.S.C. (2008) Chapter 10 Some Applications of Nanoparticles. Handbook of Metal Physics 5: 365 – 380
- Tsang, S.C., Yu, C.H., Tang, H., He, Y., Castelletto, V., Hamley, I.W., Narayanan, T., Lo, C.C.H., Tam, K. (2008) Assembly of centimeter long silica coated FePt colloid crystals with tailored interstices by magnetic crystallization. Chemistry of Materials 20 (14): 4554 – 4556
- Colclough, N., Hunter, A., Kenny, P.W., Kittlety, R.S., Lobedan, L., Tam, K.Y., Timms, M.A. (2008) High throughput solubility determination with application to selection of compounds for fragment screening. Bioorganic and Medicinal Chemistry 16 (13): 6611 – 6616
- Yiu, K.F.C., Yu, C.H., Tang, H., He, Y., Tsang, S.C., Tam, K.Y. (2008) Assembly of superparamagnetic nanoparticles under unidirectional external magnetic flux: Experimental and model establishments. Journal of Physical Chemistry C 112 (20): 7599 – 7604
- Molloy, B.-J., Tam, K.Y., Matthew Wood, J., Dryfe, R.A.W. (2008) A hydrodynamic approach to the measurement of the permeability of small molecules across artificial membranes. Analyst 133 (5): 655 – 659
- Yu, C.H., Lo, C.C.H., Tam, K., Tsang, S.C. (2007) Monodisperse binary nanocomposite in silica with enhanced magnetization for magnetic separation. Journal of Physical Chemistry C 111 (22): 7879 – 7882
- Yu, C.H., Tam, K.Y., Lo, C.C.H., Tsang, S.C. (2007) Functionalized silica coated magnetic nanoparticles with biological species for magnetic separation. IEEE Transactions on Magnetics 43 (6): 2436 – 2438
- Tsang, S.C., Yu, C.H., Gao, X., Tam, K.Y. (2006) Preparation of nanomagnetic absorbent for partition coefficient measurement. International Journal of Pharmaceutics 327 (43862): 139 – 144
- Yu, C.H., Lo, C.C.H., Tam, K., Tsang, S.C. (2006) Tailoring FePt-Fe<inf>3</inf>O<inf>4</inf> exchange spring coupling magnet in silica. 2006 NSTI Nanotechnology Conference and Trade Show – NSTI Nanotech 2006 Technical Proceedings 1: 415 – 418
- Yu, C.H., Lo, C.C.H., Yeung, C.M.Y., Tam, K., Tsang, S.C. (2006) Nano-engineering of magnetic particles for bio catalysis and bioseparation. 2006 NSTI Nanotechnology Conference and Trade Show – NSTI Nanotech 2006 Technical Proceedings 1: 513 – 516
- Yu, C.H., Caiulo, N., Lo, C.C.H., Tam, K., Tsang, S.C. (2006) Synthesis and fabrication of a thin film containing silica-encapsulated face-centered tetragonal FePt nanoparticles. Advanced Materials 18 (17): 2312 – 2314
- Tsang, S.C., Yu, C.H., Gao, X., Tam, K. (2006) Silica-encapsulated nanomagnetic particle as a new recoverable biocatalyst carrier. Journal of Physical Chemistry B 110 (34): 16914 – 16922
- Tsang, S.C., Tam, K., Gao, X., Yu, C.H., Yeung, C.M.Y., Yu, K.K.M. (2005) Novel magnetic separable nano-carriers for chemical catalysis & bio-catalysis. 2005 NSTI Nanotechnology Conference and Trade Show – NSTI Nanotech 2005 Technical Proceedings : 615 – 618
- Gao, X., Tam, K., Yu, K.M.K., Tsang, S.C. (2005) Synthesis and characterization of thiol-capped FePt nanomagnetic porous particles. Small 1 (10): 949 – 952
- Gao, X., Yu, C.H., Tam, K.Y., Tsang, S.C. (2005) New magnetic nano-absorbent for the determination of n-octanol/water partition coefficients. Journal of Pharmaceutical and Biomedical Analysis 38 (2): 197 – 203
- McKenzie, K.J., Marken, F., Gao, X., Tsang, S.C., Tam, K.Y. (2003) Quartz crystal microbalance monitoring of density changes in mesoporous TiO<inf>2</inf> phytate films during redox and ion exchange processes. Electrochemistry Communications 5 (4): 286 – 291
- Gao, X., Yu, K.M.K., Tam, K.Y., Tsang, S.C. (2003) Colloidal stable silica encapsulated nano-magnetic composite as a novel bio-catalyst carrier. Chemical Communications 3 (24): 2998 – 2999
- Zissimos, A.M., Abraham, M.H., Du, C.M., Valko, K., Bevan, C., Reynolds, D., Wood, J., Tam, K.Y. (2002) Calculation of Abraham descriptors from experimental data from seven HPLC systems; Evaluation of five different methods of calculation. Journal of the Chemical Society. Perkin Transactions 2 (12): 2001 – 2010
- Zissimos, A.M., Abraham, M.H., Barker, M.C., Box, K.J., Tam, K.Y. (2002) Calculation of Abraham descriptors from solvent–water partition coefficients in four different systems; evaluation of different methods of calculation. Journal of the Chemical Society. Perkin Transactions 2 2 (3): 470 – 477
- Hendriksen, B.A., Sanchez-Felix, M.V., Tam, K.Y. (2002) A new multiwavelength spectrophotometric method for the determination of the molar absorption coefficients of ionizable drugs. Spectroscopy Letters 35 (1): 9 – 19
- Tam, K.Y. (2001) Multiwavelength spectrophotometric resolution of the micro-equilibria of a triprotic amphoteric drug: Methacycline. Mikrochimica Acta 136 (43862): 91 – 97
- Tam, K.Y., Takács-Novák, K. (2001) Multi-wavelength spectrophotometric determination of acid dissociation constants: A validation study. Analytica Chimica Acta 434 (1): 157 – 167
- Tam, K.Y., Quere, L. (2001) Multiwavelength spectrophotometric resolution of the micro-equilibria of cetirizine. Analytical Sciences 17 (10): 1203 – 1208
- Tam, K.Y. (2000) Multiwavelength spectrophotometric determination of acid dissociation constants. Deconvolution of binary mixtures of ionizable compounds. Analytical Letters 33 (1): 145 – 161
- Takács-Novák, K., Tam, K.Y. (2000) Multiwavelength spectrophotometric determination of acid dissociation constants. Part V: Microconstants and tautomeric ratios of diprotic amphoteric drugs. Journal of Pharmaceutical and Biomedical Analysis 21 (6): 1171 – 1182
- Tam, K.Y. (1999) BUFMAKE: A computer program to calculate the compositions of buffers of defined buffer capacity and ionic strength for ultra-violet spectrophotometry. Computers and Chemistry 23 (5): 415 – 419
- Avdeef, A., Box, K.J., Comer, J.E.A., Gilges, M., Hadley, M., Hibbert, C., Patterson, W., Tam, K.Y. (1999) PH-metric logP 11. pK(a) determination of water-insoluble drugs in organic solvent-water mixtures. Journal of Pharmaceutical and Biomedical Analysis 20 (4): 631 – 641
- Mitchell, R.C., Salter, C.J., Tam, K.Y. (1999) Multiwavelength spectrophotometric determination of acid dissociation constantsPart III. Resolution of multi-protic ionization systems. Journal of Pharmaceutical and Biomedical Analysis 20 (43862): 289 – 295
- Tam, K.Y., Takács-Novák, K. (1999) Multiwavelength spectrophotometric determination of acid dissociation constants: Part II. First derivative vs. target factor analysis. Pharmaceutical Research 16 (3): 374 – 381
- Tam, K.Y., Hadley, M., Patterson, W. (1999) Multiwavelength spectrophotometric determination of acid dissociation constants part IV. Water-insoluble pyridine derivatives. Talanta 49 (3): 539 – 546
- Allen, R.I., Box, K.J., Comer, J.E.A., Peake, C., Tam, K.Y. (1998) Multiwavelength spectrophotometric determination of acid dissociation constants of ionizable drugs. Journal of Pharmaceutical and Biomedical Analysis 17 (43955): 699 – 712
- Avdeef, A., Box, K.J., Comer, J.E.A., Hibbert, C., Tam, K.Y. (1998) pH-Metric logP 10. Determination of liposomal membrane-water partition coefficients of ionizable drugs. Pharmaceutical Research 15 (2): 209 – 215
- Wang, R.L., Tam, K.Y., Compton, R.G. (1997) Applications of the channel flow cell for UV-visible spectroelectrochemical studies part 3. Do radical cations and anions have similar diffusion coefficients to their neutral parent molecules?. Journal of Electroanalytical Chemistry 434 (43862): 105 – 114
- Tam, K.Y., Smith, E.R., Booth, J., Compton, R.G., Brennan, C.M., Atherton, J.H. (1997) Kinetics and mechanism of dyeing processes: The dyeing of cotton fabrics with a procion blue dichlorotriazinyl reactive dye. Journal of Colloid and Interface Science 186 (2): 387 – 398
- Yip, K., Tam, K.Y., Yiu, K.F.C. (1997) An efficient method of determining diffusion coefficients using eigenfunction expansions. Journal of Chemical Information and Computer Sciences 37 (2): 367 – 371
- Yiu, K.F.C., Tam, K.Y., Tsang, S.C. (1997) Crystal indexing method using a simulated annealing algorithm with particular applications in nanocrystal research. Journal of Computational Chemistry 18 (2): 290 – 299
- Wang, R.L., Tam, K.Y., Marken, F., Compton, R.G. (1997) Applications of the Channel Flow Cell for UV-Visible Spectroelectrochemical Studies. Part 2: Transient Signals. Electroanalysis 9 (4): 284 – 287
- Tam, K.Y., Wang, R.L., Lee, C.W., Compton, R.G. (1997) Applications of the Channel Flow Cell for UV-Visible Spectroelectrochemical Studies: The Kinetics of Dimerization of the Methyl Viologen Radical Cation. Electroanalysis 9 (3): 219 – 224
- Tam, K.Y., Larsen, J.P., Coles, B.A., Compton, R.G. (1996) A channel flow cell with downstream impedance spectroscopy detection: Theory and applications. Journal of Electroanalytical Chemistry 407 (43862): 23 – 35
- Tam, K.Y., Compton, R.G., Atherton, J.H., Brennan, C.M., Docherty, R. (1996) Mechanism of solid/liquid interfacial reactions. The hydrolytic dissolution of solid triphenylmethyl chloride in aqueous solution. Journal of the American Chemical Society 118 (18): 4419 – 4426
- Baltzer, P., Chau, F.T., Eland, J.H.D., Karlsson, L., Lundqvist, M., Rostas, J., Tam, K.Y., Veenhuizen, H., Wannberg, B. (1996) A study of the vibronic structure in the Hel excited photoelectron spectrum of CO<inf>2</inf> involving the X2∏<inf>g</inf> and A2∏<inf>u</inf> ionic states. Journal of Chemical Physics 104 (22): 8922 – 8931
- Tam, K.Y., Chau, F.T. (1995) Applications of the terminate and stay resident programming technique for enhancing chemical measurements. Computers and Chemistry 19 (4): 389 – 393
- Tam, K.Y., Chau, F.T. (1994) Multivariate study of kinetic data for a two-step consecutive reaction using target factor analysis. Chemometrics and Intelligent Laboratory Systems 25 (1): 25 – 42
- Chau, F.T., Tam, K.Y. (1994) Application of the fast fourier transform method for compression of spectral data obtained from a photodiode array spectrophotometer. Computers and Chemistry 18 (1): 13 – 20
- Chau, F.T., Cheung, B., Tam, K.Y., Li, L.K. (1994) Application of a bi-directional associative memory (BAM) network in computer assisted learning in chemistry. Computers and Chemistry 18 (4): 359 – 362
- Tam, K.Y., Chau, F.T. (1993) Simultaneous multi-wavelength study of the reduction reaction of chromic acid with oxalic acid using a photodiode array spectrophotometer. Spectroscopy Letters 26 (7): 1195 – 1212
- Chau, F.T., Tam, K.Y., Lau, K.S., Wong, K.H. (1993) A computer-based trigger system for a laser induced plasma spectrometer. Computers and Chemistry 17 (1): 11 – 17
- Chau, F.T., Tam, K.Y. (1992) Controlling a stepper motor: Using the IBM PC communication port. Journal of Chemical Education 69 (5): a154 – 156
- Tam, K.Y., Chau, F.T. (1992) Simultaneous multiwavelength study of the reaction of phenolphthalein with sodium hydroxide. Journal of Automatic Chemistry 14 (5): 157 – 162