2020-12-15T17:14:13+08:002020-03-06|Publish|

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  1. Ju, Y., Tam, K.Y. (2020) 9R, the cholinesterase and amyloid beta aggregation dual inhibitor, as a multifunctional agent to improve cognitive deficit and neuropathology in the triple-transgenic Alzheimer’s disease mouse model. Neuropharmacology 181
  2. Ju, Y., Chakravarty, H., Tam, K.Y. (2020) An Isoquinolinium Dual Inhibitor of Cholinesterases and Amyloid β Aggregation Mitigates Neuropathological Changes in a Triple-Transgenic Mouse Model of Alzheimer’s Disease. ACS Chemical Neuroscience 11 (20): 3346 – 3357
  3. Hong, X.-Q., He, X.-Y., Tam, K.Y., Chen, W.-H. (2020) Synthesis and biological effect of lysosome-targeting fluorescent anion transporters with enhanced anionophoric activity. Bioorganic and Medicinal Chemistry Letters 30 (19)
  4. Xiang, S., Huang, D., He, Q., Li, J., Tam, K.Y., Zhang, S.-L., He, Y. (2020) Development of dual inhibitors targeting pyruvate dehydrogenase kinases and human lactate dehydrogenase A: High-throughput virtual screening, synthesis and biological validation. European Journal of Medicinal Chemistry 203
  5. Chakravarty, H., Ju, Y., Chen, W.-H., Tam, K.Y. (2020) Dual targeting of cholinesterase and amyloid beta with pyridinium/isoquinolium derivatives. Drug Development Research 81 (2): 242 – 255
  6. Yang, Z., Chan, K.I., Kwok, H.F., Tam, K.Y. (2019) Novel Therapeutic Anti-ADAM17 Antibody A9(B8) Enhances EGFR-TKI–Mediated Anticancer Activity in NSCLC. Translational Oncology 12 (11): 1516 – 1524
  7. Cui, M., Ying, R., Jiang, X., Li, G., Zhang, X., Zheng, J., Tam, K.Y., Liang, B., Shi, A., Göbel, V., Zhang, H. (2019) A Model of Hereditary Sensory and Autonomic Neuropathy Type 1 Reveals a Role of Glycosphingolipids in Neuronal Polarity. The Journal of neuroscience : the official journal of the Society for Neuroscience 39 (29): 5816 – 5834
  8. Verma, A., Lam, Y.-M., Leung, Y.-C., Hu, X., Chen, X., Cheung, E., Tam, K.Y. (2019) Combined use of arginase and dichloroacetate exhibits anti-proliferative effects in triple negative breast cancer cells. Journal of Pharmacy and Pharmacology 71 (3): 306 – 315
  9. Cheng, X., Jiang, X., Tam, K.Y., Li, G., Zheng, J., Zhang, H. (2019) Sphingolipidomic analysis of c. Elegans reveals development-and environment-dependent metabolic features. International Journal of Biological Sciences 15 (13): 2897 – 2910
  10. Yu, X.-H., Cai, X.-J., Hong, X.-Q., Tam, K.Y., Zhang, K., Chen, W.-H. (2019) Synthesis and biological evaluation of aza-crown ether-squaramide conjugates as anion/cation symporters. Future Medicinal Chemistry 11 (10): 1091 – 1106
  11. Wu, X., Kosaraju, J., Tam, K.Y. (2018) Anti-neuroinflammatory effects of SLOH in Aβ-induced BV-2 microglial cells and 3xTg-AD mice involve the inhibition of GSK-3β. Neuroscience Letters 687: 207 – 215
  12. Zhang, S.-L., Yang, Z., Hu, X., Tam, K.Y. (2018) Dichloroacetophenones targeting at pyruvate dehydrogenase kinase 1 with improved selectivity and antiproliferative activity: Synthesis and structure-activity relationships. Bioorganic and Medicinal Chemistry Letters 28 (21): 3441 – 3445
  13. Zhang, W., Hu, X., Chakravarty, H., Yang, Z., Tam, K.Y. (2018) Identification of Novel Pyruvate Dehydrogenase Kinase 1 (PDK1) Inhibitors by Kinase Activity-Based High-Throughput Screening for Anticancer Therapeutics. ACS Combinatorial Science 20 (11): 660 – 671
  14. Yang, Z., Zhang, S.-L., Hu, X., Tam, K.Y. (2018) Inhibition of pyruvate dehydrogenase kinase 1 enhances the anti-cancer effect of EGFR tyrosine kinase inhibitors in non-small cell lung cancer. European Journal of Pharmacology 838: 41 – 52
  15. Tam, K., Li, T., Mandić, Z. (2018) Editorial, IAPC-6 Meeting. Pharmaceutical Research 35 (11)
  16. Zhang, S.-L., Yang, Z., Hu, X., Chakravarty, H., Tam, K.Y. (2018) Anticancer effects of some novel dichloroacetophenones through the inhibition of pyruvate dehydrogenase kinase 1. European Journal of Pharmaceutical Sciences 123: 43 – 55
  17. Zhang, W., Hu, X., Zhou, W., Tam, K.Y. (2018) Liquid Chromatography-Tandem Mass Spectrometry Method Revealed that Lung Cancer Cells Exhibited Distinct Metabolite Profiles upon the Treatment with Different Pyruvate Dehydrogenase Kinase Inhibitors. Journal of Proteome Research 17 (9): 3012 – 3021
  18. Wang, X.X., Li, Z.Y., Tian, Y., Wang, W., Pang, Y., Tam, K.Y. (2018) Two dimensional photoacoustic imaging using microfiber interferometric acoustic transducers. Optics Communications 419: 41 – 46
  19. Zhang, S.-L., He, Y., Tam, K.Y. (2018) Targeting cancer metabolism to develop human lactate dehydrogenase (hLDH)5 inhibitors. Drug Discovery Today 23 (7): 1407 – 1415
  20. Lyu, J., Yang, E.J., Head, S.A., Ai, N., Zhang, B., Wu, C., Li, R.-J., Liu, Y., Chakravarty, H., Zhang, S., Tam, K.Y., Dang, Y., Kwon, H.J., Ge, W., Liu, J.O., Shim, J.S. (2018) Astemizole inhibits mTOR signaling and angiogenesis by blocking cholesterol trafficking. International Journal of Biological Sciences 14 (10): 1175 – 1185
  21. Hu, J., Tan, S.K., Lim, M.G.L., Chang, S.H., Cui, G., Liu, S., Narasimhan, K., New, S.Y., Wang, X., Chen, C., Chakravarty, H., Kolatkar, P.R., Tam, K.Y., Lu, Q., Su, X., Jauch, R., Cheung, E. (2018) Identification of a Wells-Dawson polyoxometalatebased AP-2γ inhibitor with pro-apoptotic activity. Biochemical Journal 475 (11): 1965 – 1977
  22. Tian, Y., Xu, W., Zhang, H., Tam, K.Y., Zhang, H., Yang, L., Li, Z., Pang, Y. (2018) The scalp time-varying networks of N170: Reference, latency, and information flow. Frontiers in Neuroscience 12 (APR)
  23. Wu, X., Kosaraju, J., Zhou, W., Tam, K.Y. (2018) SLOH, a carbazole-based fluorophore, mitigates neuropathology and behavioral impairment in the triple-transgenic mouse model of Alzheimer’s disease. Neuropharmacology 131: 351 – 363
  24. Tam, K., Mandić, Z. (2018) Special issue devoted to the 6th IAPC meeting: Joint events comprising 6th world conference on physico-chemical methods in drug discovery and development and 3rd world conference on ADMET and DMPK. ADMET and DMPK 6 (1): 1 – 3
  25. Yang, Z., Tam, K.Y. (2018) Combination strategies using EGFR-TKi in NSCLC therapy: Learning from the gap between pre-clinical results and clinical outcomes. International Journal of Biological Sciences 14 (2): 204 – 216
  26. Mandić, Z., Tam, K. (2017) Editorial, IAPC-5 Special Issue. European Journal of Pharmaceutical Sciences 110: 1 –
  27. Wu, X., Kosaraju, J., Tam, K.Y. (2017) SLM, a novel carbazole-based fluorophore attenuates okadaic acid-induced tau hyperphosphorylation via down-regulating GSK-3β activity in SH-SY5Y cells. European Journal of Pharmaceutical Sciences 110: 101 – 108
  28. Zhang, W., Zhang, S.-L., Hu, X., Tam, K.Y. (2017) Phenyl butyrate inhibits pyruvate dehydrogenase kinase 1 and contributes to its anti-cancer effect. European Journal of Pharmaceutical Sciences 110: 93 – 100
  29. Zhang, S.-L., Zhang, W., Yang, Z., Hu, X., Tam, K.Y. (2017) Synthesis and biological evaluation of (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionamides as pyruvate dehydrogenase kinase 1 (PDK1) inhibitors to reduce the growth of cancer cells. European Journal of Pharmaceutical Sciences 110: 87 – 92
  30. Guo, L.X., Liu, J.H., Zheng, X.X., Yin, Z.Y., Kosaraju, J., Tam, K.Y. (2017) Geniposide improves insulin production and reduces apoptosis in high glucose-induced glucotoxic insulinoma cells. European Journal of Pharmaceutical Sciences 110: 70 – 76
  31. Zhou, W., Hu, X., Tam, K.Y. (2017) Systemic clearance and brain distribution of carbazole-based cyanine compounds as Alzheimer’s disease drug candidates. Scientific Reports 7 (1)
  32. Yang, Z., Hu, X., Zhang, S., Zhang, W., Tam, K.Y. (2017) Pharmacological synergism of 2,2-dichloroacetophenone and EGFR-TKi to overcome TKi-induced resistance in NSCLC cells. European Journal of Pharmacology 815: 80 – 87
  33. Kosaraju, J., Holsinger, R.M.D., Guo, L., Tam, K.Y. (2017) Linagliptin, a Dipeptidyl Peptidase-4 Inhibitor, Mitigates Cognitive Deficits and Pathology in the 3xTg-AD Mouse Model of Alzheimer’s Disease. Molecular Neurobiology 54 (8): 6074 – 6084
  34. Tian, Y., Yang, L., Chen, S., Guo, D., Ding, Z., Tam, K.Y., Yao, D. (2017) Causal interactions in resting-state networks predict perceived loneliness. PLoS ONE 12 (5)
  35. Wu, X., Kosaraju, J., Zhou, W., Tam, K.Y. (2017) Neuroprotective Effect of SLM, a Novel Carbazole-Based Fluorophore, on SH-SY5Y Cell Model and 3xTg-AD Mouse Model of Alzheimer’s Disease. ACS Chemical Neuroscience 8 (3): 676 – 685
  36. Hu, X., Tam, K.Y. (2017) Association of vancomycin with lipid vesicles. ADMET and DMPK 5 (3): 182 – 191
  37. Hu, X., Tam, K. (2017) Biomembrane mimics and their roles in anti-bacterial drug discovery. ADMET and DMPK 5 (1): 9 – 13
  38. Peters, G.J., Tam, K. (2016) ADME/DMPK in the development and use of tyrosine and serine-threonine kinase inhibitors. ADMET and DMPK 4 (3): 182 – 185
  39. Peng, X.-M., Peng, L.-P., Li, S., Avula, S.R., Kannekanti, V.K., Zhang, S.-L., Tam, K.Y., Zhou, C.-H. (2016) Quinazolinone azolyl ethanols: Potential lead antimicrobial agents with dual action modes targeting methicillin-resistant Staphylococcus aureus DNA. Future Medicinal Chemistry 8 (16): 1927 – 1940
  40. Xiao, Q., Hu, X., Wei, Z., Tam, K.Y. (2016) Cytoskeleton molecular motors: Structures and their functions in neuron. International Journal of Biological Sciences 12 (9): 1083 – 1092
  41. Zhang, S.-L., Hu, X., Zhang, W., Tam, K.Y. (2016) Unexpected Discovery of Dichloroacetate Derived Adenosine Triphosphate Competitors Targeting Pyruvate Dehydrogenase Kinase to Inhibit Cancer Proliferation. Journal of Medicinal Chemistry 59 (7): 3562 – 3568
  42. Zhou, W., Wu, X., Li, J., Hu, X., Tam, K.Y. (2016) Quantification of permanent positively charged compounds in plasma using one-step dilution to reduce matrix effect in MS. Bioanalysis 8 (6): 497 – 509
  43. Yang, Z., Tam, K.Y. (2016) Anti-cancer synergy of dichloroacetate and EGFR tyrosine kinase inhibitors in NSCLC cell lines. European Journal of Pharmacology 789: 458 – 467
  44. Zhang, S.-L., Zhang, W., Xiao, Q., Yang, Z., Hu, X., Wei, Z., Tam, K.Y. (2016) Development of dichloroacetamide pyrimidines as pyruvate dehydrogenase kinase inhibitors to reduce cancer cell growth: Synthesis and biological evaluation. RSC Advances 6 (82): 78762 – 78767
  45. Yin, G., Wang, P., Lang, J., Tian, Y., Luo, Y., Fan, Z., Tam, K.Y. (2016) Dosimetric study for cervix carcinoma treatment using intensity modulated radiation therapy (IMRT) compensation based on 3D intracavitary brachytherapy technique. Journal of Contemporary Brachytherapy 8 (3): 221 – 232
  46. Zhang, W., Zhang, S.-L., Hu, X., Tam, K.Y. (2015) Targeting tumor metabolism for cancer treatment: Is pyruvate dehydrogenase kinases (PDKs) a viable anticancer target?. International Journal of Biological Sciences 11 (12): 1390 – 1400
  47. Dohoda, D., Tsinman, K., Tsinman, O., Wang, H., Tam, K.Y. (2015) Spectrophotometric pK<inf>a</inf> determination of ionizable pharmaceuticals: Resolution of molecules with weak pH-dependent spectral shift. Journal of Pharmaceutical and Biomedical Analysis 114: 88 – 96
  48. Zhang, S.-L., Hu, X., Zhang, W., Yao, H., Tam, K.Y. (2015) Development of pyruvate dehydrogenase kinase inhibitors in medicinal chemistry with particular emphasis as anticancer agents. Drug Discovery Today 20 (9): 1112 – 1119
  49. Tam, K. (2015) Research in neurodegenerative diseases: Challenges and solutions. ADMET and DMPK 3 (3): 154 –
  50. Li, J., Zhou, W., Wu, X., Tam, K. (2015) Chemical and physical approaches for the treatment of Alzheimer’s disease. ADMET and DMPK 3 (3): 216 – 234
  51. Wu, X., Li, J., Zhou, W., Tam, K. (2015) Animal models for Alzheimer’s disease: A focused review of transgenic rodent models and behavioral assessment methods. ADMET and DMPK 3 (3): 242 – 253
  52. Tian, Y., Ding, Z., Tam, K.Y., Wang, Z., Zhang, H., Zhao, D., Zhao, Y., Xu, W., Zheng, S. (2015) Specific frequency bands of amplitude low-frequency fluctuations in memory-related cognitive impairment: Predicting Alzheimer’s disease. ADMET and DMPK 3 (3): 274 – 280
  53. Zhou, W., Tam, K.Y., Meng, M., Shan, J., Wang, S., Ju, W., Cai, B., Di, L. (2015) Pharmacokinetics screening for multi-components absorbed in the rat plasma after oral administration of traditional Chinese medicine Flos Lonicerae Japonicae-Fructus Forsythiae herb couple by sequential negative and positive ionization ultra-high-performance liquid chromatography/tandem triple quadrupole mass spectrometric detection. Journal of Chromatography A 1376: 84 – 97
  54. Jampilek, J., Crowley, P.J., Olsen, M., Tam, K. (2015) Modern approaches to quality assurance of drug formulations. BioMed Research International 2015
  55. Zhang, S.-L., Yao, H., Wang, C., Tam, K.Y. (2014) Study the interactions between human serum albumin and two antifungal drugs: Fluconazole and its analogue DTP. Bioorganic and Medicinal Chemistry Letters 24 (21): 4963 – 4968
  56. Velický, M., Rodgers, A.N.J., Dryfe, R.A.W., Tam, K. (2014) Use of voltammetry for in vitro equilibrium and transport studies of ionisable drugs. ADMET and DMPK 2 (3): 143 – 156
  57. Tam, K., Mandić, Z. (2014) Special issue devoted to the 3rd world conference on physico-chemical methods in drug discovery and development (PCMDDD-3). ADMET and DMPK 2 (1): 1 – 2
  58. Velický, M., Tam, K.Y., Dryfe, R.A.W. (2014) Mechanism of ion transfer in supported liquid membrane systems: Electrochemical control over membrane distribution. Analytical Chemistry 86 (1): 435 – 442
  59. Wen, Z., Chenyin, W., Tam, K.Y. (2014) Predicting the minimal inhibitory concentration of fluoroquinolones for Escherichia coli using an accumulation model. Bio-Medical Materials and Engineering 24 (6): 3745 – 3751
  60. Chenyin, W., Avdeef, A., Wen, Z., Tam, K.Y. (2014) Predicting the human jejunal permeability and fraction absorbed of fluoroquinolones based on a biophysical model. Bio-Medical Materials and Engineering 24 (6): 3849 – 3854
  61. Tam, K. (2013) One year in circulation – an exciting journey for ADMET &amp; DMPK. ADMET and DMPK 1 (4): 46 – 47
  62. Tam, K. (2013) Estimating the “first in human” dose – a revisit with particular emphasis on oncology drugs. ADMET and DMPK 1 (4): 63 – 75
  63. Francine, E., Tsakmaka, C., Mohr, S., Fielden, P.R., Goddard, N.J., Booth, J., Tam, K.Y. (2013) Using droplet-based microfluidic technology to study the precipitation of a poorly water-soluble weakly basic drug upon a pH-shift. Analyst 138 (1): 339 – 345
  64. Tam, K. (2013) The roles of doxorubicin in hepatocellular carcinoma. ADMET and DMPK 1 (3): 29 – 44
  65. Foote, K.M., Blades, K., Cronin, A., Fillery, S., Guichard, S.S., Hassall, L., Hickson, I., Jacq, X., Jewsbury, P.J., McGuire, T.M., Nissink, J.W.M., Odedra, R., Page, K., Perkins, P., Suleman, A., Tam, K., Thommes, P., Broadhurst, R., Wood, C. (2013) Discovery of 4-{4-[(3R)-3-methylmorpholin-4-yl]-6-[1-(methylsulfonyl) cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): A potent and selective inhibitor of ATR protein kinase with monotherapy in vivo antitumor activity. Journal of Medicinal Chemistry 56 (5): 2125 – 2138
  66. Tam, K. (2013) Close relationships between in vitro ADMET and DMPK research in pre-clinical drug discovery. ADMET and DMPK 1 (1): 1 – 2
  67. Velický, M., Tam, K.Y., Dryfe, R.A.W. (2012) Hydrodynamic voltammetry at the liquid-liquid interface: Application to the transfer of ionised drug molecules. Journal of Electroanalytical Chemistry 683: 94 – 102
  68. Eblagon, K.M., Tam, K., Tsang, S.C.E. (2012) Comparison of catalytic performance of supported ruthenium and rhodium for hydrogenation of 9-ethylcarbazole for hydrogen storage applications. Energy and Environmental Science 5 (9): 8621 – 8630
  69. Völgyi, G., Vizserálek, G., Takács-Novák, K., Avdeef, A., Tam, K.Y. (2012) Predicting the exposure and antibacterial activity of fluoroquinolones based on physicochemical properties. European Journal of Pharmaceutical Sciences 47 (1): 21 – 27
  70. Lee, G.K.-C., Kwok, S.-Y., Hao Yu, C., Tam, K., Chong, H.-C., Leung, Y.-C., Edman Tsang, S.C. (2012) Immobilization of engineered arginase on gold-carbon nanotubes. Chemical Communications 48 (62): 7693 – 7695
  71. Velický, M., Tam, K.Y., Dryfe, R.A.W. (2012) On the stability of the silver/silver sulfate reference electrode. Analytical Methods 4 (5): 1207 – 1211
  72. Eblagon, K.M., Tam, K., Yu, K.M.K., Tsang, S.C.E. (2012) Comparative study of catalytic hydrogenation of 9-ethylcarbazole for hydrogen storage over noble metal surfaces. Journal of Physical Chemistry C 116 (13): 7421 – 7429
  73. Velický, M., Tam, K.Y., Dryfe, R.A.W. (2012) Permeation of a fully ionized species across a polarized supported liquid membrane. Analytical Chemistry 84 (5): 2541 – 2547
  74. Velický, M., Tam, K.Y., Dryfe, R.A.W. (2011) In situ artificial membrane permeation assay under hydrodynamic control: Correlation between drug in vitro permeability and fraction absorbed in humans. European Journal of Pharmaceutical Sciences 44 (3): 299 – 309
  75. Tam, K.Y., Leung, K.C.-F., Wang, Y.-X.J. (2011) Chemoembolization agents for cancer treatment. European Journal of Pharmaceutical Sciences 44 (43862): 1 – 10
  76. Yu, C.H., Tam, K., Tsang, S.C. (2011) A new high-throughput method utilizing porous silica-based nano-composites for the determination of partition coefficients of drug candidates. Journal of Separation Science 34 (18): 2505 – 2512
  77. Chan, C.W.A., Tam, K.Y., Cookson, J., Bishop, P., Tsang, S.C. (2011) Palladium with interstitial carbon atoms as a catalyst for ultraselective hydrogenation in the liquid phase. Catalysis Science and Technology 1 (9): 1584 – 1592
  78. Buttar, D., Colclough, N., Gerhardt, S., MacFaul, P.A., Phillips, S.D., Plowright, A., Whittamore, P., Tam, K., Maskos, K., Steinbacher, S., Steuber, H. (2010) A combined spectroscopic and crystallographic approach to probing drug-human serum albumin interactions. Bioorganic and Medicinal Chemistry 18 (21): 7486 – 7496
  79. Velický, M., Bradley, D.F., Tam, K.Y., Dryfe, R.A.W. (2010) In situ artificial membrane permeation assay under hydrodynamic control: Permeability-ph profiles of warfarin and verapamil. Pharmaceutical Research 27 (8): 1644 – 1658
  80. Morawa Eblagon, K., Tam, K., Yu, K.M.K., Zhao, S.-L., Gong, X.-Q., He, H., Ye, L., Wang, L.-C., Ramirez-Cuesta, A.J., Tsang, S.C. (2010) Study of catalytic sites on ruthenium for hydrogenation of N-ethylcarbazole: Implications of hydrogen storage via reversible catalytic hydrogenation. Journal of Physical Chemistry C 114 (21): 9720 – 9730
  81. Avdeef, A., Tam, K.Y. (2010) How well can the caco-2/madin-darby canine kidney models predict effective human jejunal permeability?. Journal of Medicinal Chemistry 53 (9): 3566 – 3584
  82. Tam, K.Y., Avdeef, A., Tsinman, O., Sun, N. (2010) The permeation of amphoteric drugs through artificial membranes – An in combo absorption model based on paracellular and transmembrane permeability. Journal of Medicinal Chemistry 53 (1): 392 – 401
  83. Colclough, N., Ruston, L., Tam, K. (2009) Aqueous Solubility in Drug Discovery Chemistry, DMPK, and Biological Assays. Drug Bioavailability: Estimation of Solubility, Permeability, Absorption and Bioavailability 40: 7 – 31
  84. Lo, C.C.H., Tsang, S.C., Yu, C.H., Tam, K. (2009) Magnetic properties of macroscopic colloid crystals of silica-coated FePt nanoparticles with controllable interstices for molecular separation. Journal of Applied Physics 105 (7)
  85. Yu, C.H., Al-Saadi, A., Shih, S.-J., Qiu, L., Tam, K.Y., Tsang, S.C. (2009) Immobilization of BSA on silica-coated magnetic iron oxide nanoparticle. Journal of Physical Chemistry C 113 (2): 537 – 543
  86. Jones, C.D., Andrews, D.M., Barker, A.J., Blades, K., Daunt, P., East, S., Geh, C., Graham, M.A., Johnson, K.M., Loddick, S.A., McFarland, H.M., McGregor, A., Moss, L., Rudge, D.A., Simpson, P.B., Swain, M.L., Tam, K.Y., Tucker, J.A., Walker, M. (2008) The discovery of AZD5597, a potent imidazole pyrimidine amide CDK inhibitor suitable for intravenous dosing. Bioorganic and Medicinal Chemistry Letters 18 (24): 6369 – 6373
  87. Yu, C.-H., Tam, K., Tsang, E.S.C. (2008) Chapter 5 Chemical Methods for Preparation of Nanoparticles in Solution. Handbook of Metal Physics 5: 113 – 141
  88. Yu, C.-H., Oduro, W., Tam, K., Tsang, E.S.C. (2008) Chapter 10 Some Applications of Nanoparticles. Handbook of Metal Physics 5: 365 – 380
  89. Tsang, S.C., Yu, C.H., Tang, H., He, Y., Castelletto, V., Hamley, I.W., Narayanan, T., Lo, C.C.H., Tam, K. (2008) Assembly of centimeter long silica coated FePt colloid crystals with tailored interstices by magnetic crystallization. Chemistry of Materials 20 (14): 4554 – 4556
  90. Colclough, N., Hunter, A., Kenny, P.W., Kittlety, R.S., Lobedan, L., Tam, K.Y., Timms, M.A. (2008) High throughput solubility determination with application to selection of compounds for fragment screening. Bioorganic and Medicinal Chemistry 16 (13): 6611 – 6616
  91. Yiu, K.F.C., Yu, C.H., Tang, H., He, Y., Tsang, S.C., Tam, K.Y. (2008) Assembly of superparamagnetic nanoparticles under unidirectional external magnetic flux: Experimental and model establishments. Journal of Physical Chemistry C 112 (20): 7599 – 7604
  92. Molloy, B.-J., Tam, K.Y., Matthew Wood, J., Dryfe, R.A.W. (2008) A hydrodynamic approach to the measurement of the permeability of small molecules across artificial membranes. Analyst 133 (5): 655 – 659
  93. Yu, C.H., Lo, C.C.H., Tam, K., Tsang, S.C. (2007) Monodisperse binary nanocomposite in silica with enhanced magnetization for magnetic separation. Journal of Physical Chemistry C 111 (22): 7879 – 7882
  94. Yu, C.H., Tam, K.Y., Lo, C.C.H., Tsang, S.C. (2007) Functionalized silica coated magnetic nanoparticles with biological species for magnetic separation. IEEE Transactions on Magnetics 43 (6): 2436 – 2438
  95. Tsang, S.C., Yu, C.H., Gao, X., Tam, K.Y. (2006) Preparation of nanomagnetic absorbent for partition coefficient measurement. International Journal of Pharmaceutics 327 (43862): 139 – 144
  96. Yu, C.H., Lo, C.C.H., Tam, K., Tsang, S.C. (2006) Tailoring FePt-Fe<inf>3</inf>O<inf>4</inf> exchange spring coupling magnet in silica. 2006 NSTI Nanotechnology Conference and Trade Show – NSTI Nanotech 2006 Technical Proceedings 1: 415 – 418
  97. Yu, C.H., Lo, C.C.H., Yeung, C.M.Y., Tam, K., Tsang, S.C. (2006) Nano-engineering of magnetic particles for bio catalysis and bioseparation. 2006 NSTI Nanotechnology Conference and Trade Show – NSTI Nanotech 2006 Technical Proceedings 1: 513 – 516
  98. Yu, C.H., Caiulo, N., Lo, C.C.H., Tam, K., Tsang, S.C. (2006) Synthesis and fabrication of a thin film containing silica-encapsulated face-centered tetragonal FePt nanoparticles. Advanced Materials 18 (17): 2312 – 2314
  99. Tsang, S.C., Yu, C.H., Gao, X., Tam, K. (2006) Silica-encapsulated nanomagnetic particle as a new recoverable biocatalyst carrier. Journal of Physical Chemistry B 110 (34): 16914 – 16922
  100. Tsang, S.C., Tam, K., Gao, X., Yu, C.H., Yeung, C.M.Y., Yu, K.K.M. (2005) Novel magnetic separable nano-carriers for chemical catalysis &amp; bio-catalysis. 2005 NSTI Nanotechnology Conference and Trade Show – NSTI Nanotech 2005 Technical Proceedings : 615 – 618
  101. Gao, X., Tam, K., Yu, K.M.K., Tsang, S.C. (2005) Synthesis and characterization of thiol-capped FePt nanomagnetic porous particles. Small 1 (10): 949 – 952
  102. Gao, X., Yu, C.H., Tam, K.Y., Tsang, S.C. (2005) New magnetic nano-absorbent for the determination of n-octanol/water partition coefficients. Journal of Pharmaceutical and Biomedical Analysis 38 (2): 197 – 203
  103. McKenzie, K.J., Marken, F., Gao, X., Tsang, S.C., Tam, K.Y. (2003) Quartz crystal microbalance monitoring of density changes in mesoporous TiO<inf>2</inf> phytate films during redox and ion exchange processes. Electrochemistry Communications 5 (4): 286 – 291
  104. Gao, X., Yu, K.M.K., Tam, K.Y., Tsang, S.C. (2003) Colloidal stable silica encapsulated nano-magnetic composite as a novel bio-catalyst carrier. Chemical Communications 3 (24): 2998 – 2999
  105. Zissimos, A.M., Abraham, M.H., Du, C.M., Valko, K., Bevan, C., Reynolds, D., Wood, J., Tam, K.Y. (2002) Calculation of Abraham descriptors from experimental data from seven HPLC systems; Evaluation of five different methods of calculation. Journal of the Chemical Society. Perkin Transactions 2 (12): 2001 – 2010
  106. Zissimos, A.M., Abraham, M.H., Barker, M.C., Box, K.J., Tam, K.Y. (2002) Calculation of Abraham descriptors from solvent–water partition coefficients in four different systems; evaluation of different methods of calculation. Journal of the Chemical Society. Perkin Transactions 2 2 (3): 470 – 477
  107. Hendriksen, B.A., Sanchez-Felix, M.V., Tam, K.Y. (2002) A new multiwavelength spectrophotometric method for the determination of the molar absorption coefficients of ionizable drugs. Spectroscopy Letters 35 (1): 9 – 19
  108. Tam, K.Y. (2001) Multiwavelength spectrophotometric resolution of the micro-equilibria of a triprotic amphoteric drug: Methacycline. Mikrochimica Acta 136 (43862): 91 – 97
  109. Tam, K.Y., Takács-Novák, K. (2001) Multi-wavelength spectrophotometric determination of acid dissociation constants: A validation study. Analytica Chimica Acta 434 (1): 157 – 167
  110. Tam, K.Y., Quere, L. (2001) Multiwavelength spectrophotometric resolution of the micro-equilibria of cetirizine. Analytical Sciences 17 (10): 1203 – 1208
  111. Tam, K.Y. (2000) Multiwavelength spectrophotometric determination of acid dissociation constants. Deconvolution of binary mixtures of ionizable compounds. Analytical Letters 33 (1): 145 – 161
  112. Takács-Novák, K., Tam, K.Y. (2000) Multiwavelength spectrophotometric determination of acid dissociation constants. Part V: Microconstants and tautomeric ratios of diprotic amphoteric drugs. Journal of Pharmaceutical and Biomedical Analysis 21 (6): 1171 – 1182
  113. Tam, K.Y. (1999) BUFMAKE: A computer program to calculate the compositions of buffers of defined buffer capacity and ionic strength for ultra-violet spectrophotometry. Computers and Chemistry 23 (5): 415 – 419
  114. Avdeef, A., Box, K.J., Comer, J.E.A., Gilges, M., Hadley, M., Hibbert, C., Patterson, W., Tam, K.Y. (1999) PH-metric logP 11. pK(a) determination of water-insoluble drugs in organic solvent-water mixtures. Journal of Pharmaceutical and Biomedical Analysis 20 (4): 631 – 641
  115. Mitchell, R.C., Salter, C.J., Tam, K.Y. (1999) Multiwavelength spectrophotometric determination of acid dissociation constantsPart III. Resolution of multi-protic ionization systems. Journal of Pharmaceutical and Biomedical Analysis 20 (43862): 289 – 295
  116. Tam, K.Y., Takács-Novák, K. (1999) Multiwavelength spectrophotometric determination of acid dissociation constants: Part II. First derivative vs. target factor analysis. Pharmaceutical Research 16 (3): 374 – 381
  117. Tam, K.Y., Hadley, M., Patterson, W. (1999) Multiwavelength spectrophotometric determination of acid dissociation constants part IV. Water-insoluble pyridine derivatives. Talanta 49 (3): 539 – 546
  118. Allen, R.I., Box, K.J., Comer, J.E.A., Peake, C., Tam, K.Y. (1998) Multiwavelength spectrophotometric determination of acid dissociation constants of ionizable drugs. Journal of Pharmaceutical and Biomedical Analysis 17 (43955): 699 – 712
  119. Avdeef, A., Box, K.J., Comer, J.E.A., Hibbert, C., Tam, K.Y. (1998) pH-Metric logP 10. Determination of liposomal membrane-water partition coefficients of ionizable drugs. Pharmaceutical Research 15 (2): 209 – 215
  120. Wang, R.L., Tam, K.Y., Compton, R.G. (1997) Applications of the channel flow cell for UV-visible spectroelectrochemical studies part 3. Do radical cations and anions have similar diffusion coefficients to their neutral parent molecules?. Journal of Electroanalytical Chemistry 434 (43862): 105 – 114
  121. Tam, K.Y., Smith, E.R., Booth, J., Compton, R.G., Brennan, C.M., Atherton, J.H. (1997) Kinetics and mechanism of dyeing processes: The dyeing of cotton fabrics with a procion blue dichlorotriazinyl reactive dye. Journal of Colloid and Interface Science 186 (2): 387 – 398
  122. Yip, K., Tam, K.Y., Yiu, K.F.C. (1997) An efficient method of determining diffusion coefficients using eigenfunction expansions. Journal of Chemical Information and Computer Sciences 37 (2): 367 – 371
  123. Yiu, K.F.C., Tam, K.Y., Tsang, S.C. (1997) Crystal indexing method using a simulated annealing algorithm with particular applications in nanocrystal research. Journal of Computational Chemistry 18 (2): 290 – 299
  124. Wang, R.L., Tam, K.Y., Marken, F., Compton, R.G. (1997) Applications of the Channel Flow Cell for UV-Visible Spectroelectrochemical Studies. Part 2: Transient Signals. Electroanalysis 9 (4): 284 – 287
  125. Tam, K.Y., Wang, R.L., Lee, C.W., Compton, R.G. (1997) Applications of the Channel Flow Cell for UV-Visible Spectroelectrochemical Studies: The Kinetics of Dimerization of the Methyl Viologen Radical Cation. Electroanalysis 9 (3): 219 – 224
  126. Tam, K.Y., Larsen, J.P., Coles, B.A., Compton, R.G. (1996) A channel flow cell with downstream impedance spectroscopy detection: Theory and applications. Journal of Electroanalytical Chemistry 407 (43862): 23 – 35
  127. Tam, K.Y., Compton, R.G., Atherton, J.H., Brennan, C.M., Docherty, R. (1996) Mechanism of solid/liquid interfacial reactions. The hydrolytic dissolution of solid triphenylmethyl chloride in aqueous solution. Journal of the American Chemical Society 118 (18): 4419 – 4426
  128. Baltzer, P., Chau, F.T., Eland, J.H.D., Karlsson, L., Lundqvist, M., Rostas, J., Tam, K.Y., Veenhuizen, H., Wannberg, B. (1996) A study of the vibronic structure in the Hel excited photoelectron spectrum of CO<inf>2</inf> involving the X2∏<inf>g</inf> and A2∏<inf>u</inf> ionic states. Journal of Chemical Physics 104 (22): 8922 – 8931
  129. Tam, K.Y., Chau, F.T. (1995) Applications of the terminate and stay resident programming technique for enhancing chemical measurements. Computers and Chemistry 19 (4): 389 – 393
  130. Tam, K.Y., Chau, F.T. (1994) Multivariate study of kinetic data for a two-step consecutive reaction using target factor analysis. Chemometrics and Intelligent Laboratory Systems 25 (1): 25 – 42
  131. Chau, F.T., Tam, K.Y. (1994) Application of the fast fourier transform method for compression of spectral data obtained from a photodiode array spectrophotometer. Computers and Chemistry 18 (1): 13 – 20
  132. Chau, F.T., Cheung, B., Tam, K.Y., Li, L.K. (1994) Application of a bi-directional associative memory (BAM) network in computer assisted learning in chemistry. Computers and Chemistry 18 (4): 359 – 362
  133. Tam, K.Y., Chau, F.T. (1993) Simultaneous multi-wavelength study of the reduction reaction of chromic acid with oxalic acid using a photodiode array spectrophotometer. Spectroscopy Letters 26 (7): 1195 – 1212
  134. Chau, F.T., Tam, K.Y., Lau, K.S., Wong, K.H. (1993) A computer-based trigger system for a laser induced plasma spectrometer. Computers and Chemistry 17 (1): 11 – 17
  135. Chau, F.T., Tam, K.Y. (1992) Controlling a stepper motor: Using the IBM PC communication port. Journal of Chemical Education 69 (5): a154 – 156
  136. Tam, K.Y., Chau, F.T. (1992) Simultaneous multiwavelength study of the reaction of phenolphthalein with sodium hydroxide. Journal of Automatic Chemistry 14 (5): 157 – 162