
By appointment with Ms. Dion HUANG (dionhuang@um.edu.mo)
Course Outlines
Advanced Molecular Cell Biology
Name | Position | Office | Phone | |
---|---|---|---|---|
Dr. Kai MIAO | Research Assistant Professor (Lab Representative) | N22-4034 | +853 8822 2903 | kaimiao@um.edu.mo |
Dr. Zhihui WENG | Research Assistant Professor | N22-4032 | +853 8822 4267 | zhihuiweng@um.edu.mo |
Yangyang FENG | UM Macao Post-doctoral Fellow | N22-4032 | +853 8822 4267 | yangyangfeng@um.edu.mo |
Fangyuan SHAO | UM Macao Post-doctoral Fellow | N22-4034 | +853 8822 2903 | fangyuanshao@um.edu.mo |
Heng SUN | Post-doctoral Fellow | N22-4031 | +853 8822 4254 | HengSun@um.edu.mo |
Barani Kumar RAJENDRAN | Post-doctoral Fellow | N22-4034 | +853 8822 2903 | rbaranikumar@um.edu.mo |
Ping CHEN | Post-doctoral Fellow | N22-4032 | +853 8822 4257 | pingchen@um.edu.mo |
Jinghong CHEN | Post-doctoral Fellow | N22-4031 | +853 8822 4254 | jinghongchen@um.edu.mo |
Tak Kan CHOI | Research Assistant | N22-4034 | +853 8822 2903 | TakkanChoi@um.edu.mo |
Xu ZHANG | Research Assistant | N22-4031 | +853 8822 4254 | xzhang@um.edu.mo |
Xueying LYU | Research Assistant | N22-4034 | +853 8822 2903 | xueyinglyu@um.edu.mo |
Renbo DING | PhD Student | N22-4031 | +853 8822 4254 | |
Wenhui HAO | PhD Student | N22-4034 | +853 8822 2903 | |
Fuqiang XING | PhD Student | N22-4034 | +853 8822 2903 | |
Si CHEN | PhD Student | N22-4034 | +853 8822 2903 | |
Haipeng LEI | PhD Student | N22-4034 | +853 8822 2903 | |
Sen GUO | PhD Student | N22-4031 | +853 8822 4254 | |
Ming ZHAO | PhD Student | N22-4034 | +853 8822 2903 | |
Lei ZHANG | PhD Student | N22-4032 | +853 8822 4257 | |
Jianming ZENG | PhD Student | N22-4034 | +853 8822 2903 | |
Licen LI | PhD Student | N22-4032 | +853 8822 4257 | |
Yanwei SUN | PhD Student | N22-4031 | +853 8822 4254 | |
Cheng PENG | PhD Student | N22-4031 | +853 8822 4254 | |
Kefang LIU | PhD Student | N22-4031 | +853 8822 4254 | |
Jie LI | PhD Student | N22-4031 | +853 8822 4254 | |
Aiping ZHANG | PhD Student | N22-4031 | +853 8822 4254 | |
Ling LI | PhD Student | N22-4031 | +853 8822 4254 | |
Dongyang TANG | PhD Student | N22-4031 | +853 8822 4254 | |
Shiqi LIN | PhD Student | N22-4031 | +853 8822 4254 |
Education | |
PhD | Department of Biology, University of Utah, Salt Lake City, UT, USA (1992) |
MS | Institute of Hydrobiology, Academia Sinica, Wuhan, China (1984) |
BS | Department of Biology, West China Normal University, Nanchong, China (1982) |
Positions | |
2014.12-present | Faculty Dean / Chair Professor, Faculty of Health Sciences, University of Macau |
2000.3-2014.11 | Senior Investigator, Senior Biomedical Research Service (SBRS) Chief, Mammalian Genetics Section, National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH), Bethesda, MD, USA |
1995.5-2000.3 | Investigator (Tenure-Track), Laboratory of Biochemistry and Metabolism, NIDDK, NIH, Bethesda, MD, USA |
1992.7-1995.5 | Associate, Howard Hughes Medical Institute. Fellow, Genetics Department, Harvard Medical School, Boston, MA, USA |
1986.9-1992.7 | Dept. of Biology, University of Utah, SLC, UT, USA |
1984.9-1986.9 | Assistant Investigator, Institute of Hydrobiology, Academia Sinica, Wuhan, China |
Research Interests |
Oncogenes and tumor suppressor genes, Sirtuins; Cancer, Metabolic diseases; Aging; Stem cells, Cancer metastasis, Drug development, Cell cycle, Bioinformatics, Genome stability, Development, Gene targeting |
Representative Publications |
30 representative publications
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Full publications list |
Ongoing Research Grants and Support |
Chair Professor DENG (PI) Since 2015
Macao Government Grant 065A2 DENG (PI) 2016 – 2019 Single cell research for BRCA1-related breast stem cells and breast cancer stem cells Macao Government Grant 094A3 DENG (PI) 2016 – 2019 Using precise medicine approaches to identify cancer drivers for personalized cancer therapy Macao Government Grant MYRG2016-00139-FHS DENG (PI) 2016 – 2019 Use Sleeping Beauty system mediated insertion mutagenesis in BRCA1 breast tissue specific gene knockout mice to identify cancer-promoting network Macao Government Grant MYRG2016-00132-FHS DENG (PI) 2016 – 2019 Identification of TGF-β signaling pathway mediated signaling for the inhibition of cancer metastasis Macao Government Grant MYRG2017-00113-FHS DENG (PI) 2017 – 2020 Fibroblast Growth Factor Receptor 2 (FGFR2) and Its Cooperating Factors in Mammary Tumor Initiation and Progression University of Macau Multiple Year Grant (MYRG2019-00067-FHS) Identification of tumor suppressors for cholangiocarcinoma in liver-specific Smad4/Pten knockout mice using Crispr-Cas9 system University of Macau Grant (MYRG2020-00076-FHS) Study of immune microenvironment associated with cholangiocarcinoma development and PD-1/PD-L1 blockade response regulated by SMAD4/Pten/Cul3 signaling FDCT-0112/2019/A2 06/01/2020-05/01/2022 Functional study of Cul3 as a liver tumor suppressor and drug sensitivity regulator. FDCT-0048/2019/A1, 17/09/2019-16/09/2022 Characterization and therapeutic study of triple negative breast cancer (TNBC) subtypes induced by BRCA1-FGFR2 and related signaling”, FDCT-0011/2019/AKP, 2020-2022 Biobanking and precision oncology of several high-risk tumors in Macao and surrounding areas. FDCT-0034/2019/AGJ, 06/01/2020-05/01/2022 Precision medicine research for refractory breast cancer based on circulating tumor cells derived organoids. Natural Science Foundation of China (NSFC): 82030094, 01/2021-12/2025 Identify cancer driver mutations in triple-negative breast cancer for development of effective therapies |
Patents |
Patent: AU5028500, Publication date: 2001-12-03 Inventors: Anita B Robert, GS. Ashcorft, A Russo, James B. Mitchell, and Chuxia DENG Title: Inhibition of smad3 to prevent fibrosis and improve wound healing http://v3.espacenet.com/textdoc?DB=EPODOC&I=AU5028500&F=0 |
Awards |
NIDDK “You Make A Difference” award (2013) |
Elected as an AAAS Fellow (The American Association for the Advancement of Sciences, 2012) |
NIDDK Director’s Award (2011): 10 people including myself in my lab received this Award on 9/9/2011. “In recognition of extraordinary research in understanding mechanisms of BRAC1 and its transcriptional downstream genes in cancer, cell cycle, genetic stability, aging and metabolism”. |
NIDDK “You Make A Difference” award (2005) |
NIDDK “Serving Federal Government for Ten Years” award (2005) |
Outstanding Oversea Scholar from National Science Foundation (2002, China) |
Concept grant award from Department of Defense (2002) |
NIH-Asian & Pacific Islander American Organization (APAO) Outstanding Achievement Award (2000) |
Speak at “NIH Director’s Seminar: “The Tumor Suppressor Brca1 in Genetic Stability and Tumorigenesis. February 25, 2000”. |
Visiting Professor, University of Western Australia, Australin (Since 2011) |
Visiting Professor, Nanchong Medical College, China (2009-Present) |
Visiting Professor, Cancer Hospital, Beijing University, China (2008-Present) |
Visiting Professor, Luzhou Medical College, China (2007-Present) |
Visiting Professor, Wuhan University, China (2005-Present) |
Visiting Professor, Kyushu University, Japan (2000) |
Guest Investigator, Institute of Biotechnology, Beijing (1999-Present) |
Howard Hughes Medical Institute Postdoctoral fellowship (1992-1995) |
Teaching assistant fellowship, University of Utah (1986-1992) |
The second award from “The Genetics Association of Hubei Province ” in 1986 |
Seventeen postdoctoral fellows in my laboratory received NIH-wide “Fellows Award for Research Excellence” (FARE) 23 times |
Professional Activities |
Scientific Leadership and Editorial ExperienceFounding Editor-in-Chief of “International Journal of Biological Sciences” since 2006 (http://www.biolsci.org), IF (2013): 4.372 -Organizing reviewing, extensive interaction with authors/reviewers/editors, and making decisions regarding all the manuscripts received for publication in the journal. |
President (2008) for Baltimore-Washington DC Chapter, Society of Chinese Bioscientists in America (SCBA) -Direct over 150 scientists to facilitate networking, discuss their research interesting, and organize annual scientific retreat. |
President-elect (for 2016-2017) for SCBA. |
NIH Equal Opportunity and Employment Committee (2008-2011) |
NIH Central Tenure Committee (2013-2014) |
ORWH-FAES-NIH High School Summer Student Program (2013-2014) |
Community Services
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