2024-02-19T17:03:51+08:002024-02-19|
Contact Information
Research Team
Name Position Office Phone Email
Education
PhD Graduate School of Medicine, Osaka University, Japan
MSc Hokkaido University, Japan
Positions
02/2024 – Present Associate Professor, Faculty of Health Sciences, University of Macau
11/2021 – 12/2023 Associate Professor, Faculty of Medicine, Macau University of Science and Technology
11/2021 – 01/2024 Adjunct Associate Professor, School of Medicine, Chinese University of Hong Kong (SZ)
01/2020 – 10/2021 Associate Professor, School of Medicine, School of Life and Health Sciences, Chinese University of Hong Kong (SZ)
01/2012 – 12/2019 Assistant Professor, Department of Anatomy, YLL School of Medicine, National University of Singapore
01/2006 – 12/2011 Assistant Professor, Department of Paediatrics, New York Medical College
10/1999 – 12/2005 Postdoctoral Fellow, Harvard Medical School, HHMI
Research Interests
  • Redox biology in stem cell self-renewal and ageing using the fruit fly Drosophila
  • JAK/STAT signalling in cancer and development
  • Nanotoxicity using Drosophila as a platform
Representative Publications
  1. Liu S, Baeg GH, Yang Y, Goh FG, Bao H, Wagner EJ, Yang X, Cai Y (2023). The Integrator complex desensitizes cellular response to TGF-β/BMP signaling. Cell Reports, 31;42(1):112007.
  2. Viera M, Yip GW, Shen HM, Baeg GH *, Bay BH * (2021). Targeting CD82/KAI1 for Personalized Therapeutics in Surmounting Metastatic Potential in Breast Cancer. Cancers, 13(17):4486.
  3. Shao F, Pang X, Baeg GH* (2021). Targeting the JAK/STAT Signaling Pathway for Breast Cancer. Current Medicinal Chemistry, 28(25):5137-5151.
  4. Kim BH, Yi EH, Jee JG, Sandoval C, Park IC, Baeg GH*, Ye SK* (2020). The Alangium alkaloid tubulosine is a potent Janus Kinase 3 inhibitor for the treatment of leukemia and lymphoma. Journal Cellular and Molecular Medicine, 24(13):7427-38.
  5. Ng CT, Yu L, Ong CN, Bay BH, Baeg GH*. (2018). The use of Drosophila melanogaster as a model organism to study immune-nanotoxicity. Nanotoxicology, 19:1-18.
  6. Lin WY, Ng WC, Wong BSE, Teo SL, Sivananthan GD, Baeg GH, Ok YS, Wang CH. (2018). Evaluation of sewage sludge incineration ash as a potential land reclamation material. Journal of Hazardous Materials, 357:63-72.
  7. Tan WS, Baeg GH*. (2018). Maf-S regulates germline stem cell differentiation in the Drosophila Redox Biology, 15:125-134.
  8. Khanna P, Lee JS, Lee H, Baeg GH* (2018). GRAMD1B inhibits JAK/STAT-mediated cell migration in breast cancer. Scientific Reports, 8(1):9511.
  9. Tan WS, Lee QY, Wong SE, Cai Y, Baeg GH*. (2017). Redox homeostasis plays important roles in the maintenance of the Drosophila testis germline stem cells. Stem Cell Reports, 9:342-354.
  10. Ng CT, Yong LQ, Hande MP, Ong CN, Yu LE, Bay BH, Baeg GH*. (2017). Zinc oxide nanoparticles exhibit cytotoxicity and genotoxicity through oxidative stress responses in human lung fibroblasts andDrosophila melanogaster. International Journal of Nanomedicine, 12:1621-1637.
  11. Ong C, Yung LY, Bay BH, Baeg GH*. (2016). Silver nanoparticles induce reproductive toxicity in the male Drosophila melanogaster. Scientific Reports, 6:20632.
  12. Liu Z, Zhong G, Chai PC, Luo L, Liu S, Yang Y, Baeg GH, Cai Y. (2015). Coordinated niche-associated signals promote germline homeostasis in the Drosophila Journal of Cell Biology. 211(2):469-84.
  13. Ren W, Zhang Y, Li M, Wu L, Wang G, Baeg GH, You J, Li Z, Lin X. (2015). Windpipe controls Drosophila intestinal homeostasis by regulating JAK/STAT pathway via promoting receptor endocytosis and lysosomal degradation. PLoS Genetics, 11(4):e1005180.
  14. Shao F, Guo T, Chua PJ, Tang L, Thike AA, Tan PH, Bay BH, Baeg GH*. (2015). Clinicopathological significance of ARID1B in breast invasive ductal carcinoma. Histopathology, 67(5):709-18.
  15. Khanna P, Ong C, Bay BH, Baeg GH*. (2015). Nanotoxicity: An Interplay of Oxidative Stress, Inflammation and Cell Death. Nanomaterials, 5(3): 1163-1180.
  16. Ong C, Yung LY, Cai Y, Bay BH, Baeg GH*. (2015). Drosophila melanogaster as a model organism to study nanotoxicity. Nanotoxicology, 9(3):396-403.
  17. Kim BH, Kim M, Yin CH, Jee JG, Sandoval C, Lee H, Bach EA, Hahm DH, Baeg GH*. (2011). Inhibition of the signalling kinase JAK3 alleviates inflammation in monoarthritic rats. British Journal of Pharmacology, 164(1):106-18.
  18. Kim BH, Jee JG, Yin CH, Sandoval C, Jayabose S, Kitamura D, Bach EA, Baeg GH*. (2010). NSC114792, a novel small molecule identified through structure-based computational database screening, selectively inhibits JAK3. Molecular Cancer, 11:9:36.
  19. Kim BH, Oh SR, Yin CH, Lee S, Kim EA, Kim MS, Sandoval C, Jayabose S, Bach EA, Lee HK, Baeg GH*. (2010). MS-1020 is a novel small molecule that selectively inhibits JAK3 activity. British Journal of Haematology, 148(1):132-43.
  20. Kim BH, Yin CH, Guo Q, Bach EA, Lee H, Sandoval C, Jayabose S, Ulaczyk-Lesanko A, Hall DG, Baeg GH*. (2008). A small-molecule compound identified through a cell-based screening inhibits JAK/STAT pathway signaling in human cancer cells. Molecular Cancer Therapeutics, 7(9):2672-80.
  21. Bach EA, Ekas LA, Ayala-Camargo A, Flaherty MS, Lee H, Perrimon N, Baeg GH*. (2007). GFP reporters detect the activation of the Drosophila JAK/STAT pathway in vivo. Gene Expression Patterns, 7(3):323-31.
  22. Ekas LA, Baeg GH, Flaherty MS, Ayala-Camargo A, Bach EA. (2006). JAK/STAT signaling promotes regional specification by negatively regulating wingless (Wg) expression in Drosophila. Development, 133(23):4721-9.
  23. Baeg GH, Zhou R, Perrimon N. (2005). Genome-wide RNAi analysis of JAK/STAT signaling components in Drosophila. Genes & Development, 19(16):1861-70.
  24. Baeg GH, Selva EM, Goodman RM, Dasgupta R, Perrimon N. (2004). The Wingless morphogen gradient is established by the cooperative action of Frizzled and Heparan Sulfate Proteoglycan receptors. Developmental Biology, 276(1):89-100.
  25. Liu C, Li Y, Semenov M, Han C, Baeg GH, Tan Y, Zhang Z, Lin X, He X. (2002). Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism. Cell, 108(6):837-47.
  26. Selva EM, Hong K, Baeg GH, Beverley SM, Turco SJ, Perrimon N, Häcker U. (2002). Dual role of the fringe connection gene in both heparan sulphate and fringe-dependent signalling events. Nature Cell Biology, 3(9):809-15.
  27. Baeg GH, Lin X, Khare N, Baumgartner S, Perrimon N. (2001). Heparan sulfate proteoglycans are critical for the organization of the extracellular distribution of Wingless. Development, 128(1):87-94.
  28. Baeg GH, Perrimon N. (2000). Functional binding of secreted molecules to heparan sulfate proteoglycans in Drosophila. Current Opinion in Cell Biology, 12(5):575-80.
  29. Matsumine A, Ogai A, Senda T, Okumura N, Satoh K, Baeg GH, Kawahara T, Kobayashi S, Okada M, Toyoshima K, Akiyama T. (1996). Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein. Science, 272(5264):1020-3.
  30. Baeg GH, Matsumine A, Kuroda T, Bhattacharjee RN, Miyashiro I, Toyoshima K, Akiyama T. (1995). The tumour suppressor gene product APC blocks cell cycle progression from G0/G1 to S phase. EMBO Journal, 14(22):5618-25.

Book Chapter

  1. Tan WS, Cai Y, Baeg GH*. (2017). Regulation of germline stem cells and their neighbouring somatic cells in the fruit fly Drosophila melanogaster. InTechOpen Publishers, Inc. “Germ Cells”. Chapter 2.
  2. Wong SE, Khanna P, Ng CT, Baeg GH*. (2017). Mechanism of Nanotoxicity on Cells, Animals and Human Health. Nanotoxicology: Toxicity Evaluation, Risk Assessment and Management. Taylor & Francis Group. Chapter 11.
  3. Ong C, Yung LY, Bay BH, Baeg GH*. (2016). Is the fruit fly Drosophila a useful genetic model to study gold nanoparticle-induced toxicity? “New Developments in Gold Nanomaterials Research” Nova Science Publishers, Inc. Chapter 5.
Full publications list
Research Grants
01/2023 – 12/2023 M.U.S.T. Faculty Research Grant
Title: JAK/STAT signaling in stem cell niche
Role: Principal Investigator
06/2021 – 11/2021 Futian Project Preliminary Study Fund
Title: 活性氧調節劑的開發與應用
Role: Principal Investigator
01/2020 – 12/2022 University Development Fund (CUHK-SZ)
Title: Redox Signaling in Stem Cell Self-Renewal and Cancer
Role: Principal Investigator
03/2018 – 03/2021 MOE Academic Research Fund-Tier 1 FRC FY2017
Title: Characterization of ROS-induced effectors in the Drosophila germline stem cell maintenance
Role: Principal Investigator
03/2016 – 03/2019 MOE Academic Research Fund-Tier 1 FRC FY2015
Title: Role of the transcription factor STAT in stem cell niche
Role: Principal Investigator
01/2016 – 12/2017 MOE Academic Research Fund-Tier 1 FRC FY2015
Title: Reactive Oxygen Species and Stem Cell Maintenance
Role: Principal Investigator
07/2013 – 06/2016 MOE Academic Research Fund-Tier 1 FRC FY2012
Title: Elucidating the role of dGRAMD1B in the Drosophila germline stem cell self-renewal
Role: Principal Investigator
01/2012 – 12/2014 NUS Start-Up Fund
Title: Role of the JAK/STAT Signalling in the Drosophila Male Germline Stem Cell Self-Renewal
Role: Principal Investigator
01/2006 – 12/2011 Children’s Cancer Research Fund (New York, USA)
Title: Identification of small molecules that inhibit JAK/STAT activity
Role: Principal Investigator
06/2009 – 05/2011 Initiated Research Projects and Innovative, NYSTEM, USA.
Title: Elucidating the role of the JAK/STAT pathway in stem cell self-renewal
Role: co-Principal Investigator
Awards
2020 President Young Scholar, Chinese University of Hong Kong (SZ), China
2003 – 2005 Postdoctoral Research Fellowship, Charles A. King Trust, USA
1994 – 1999 Graduate Scholarship, Ministry of Education, Japan
1995 Travel Award, National Innovative Cancer Research Meeting, Japan
Professional Activities
  1. International Society for Stem Cell Research (Full Member)
  2. Genetic Society of America
  3. Children’s Oncology Group, USA
  4. New York Academy of Sciences, USA
  5. Singapore Stem Cell Society
  6. Singapore Microscopy Society
  7. Thailand Microscopy Society