2026-01-28T17:32:36+08:002021-01-21|
Contact Information
Title
Senior Instructor
Operations Manager of Animal Research Core
Office
(Address) N22-3067/E12-4024 / (Phone) +853 8822 8803
Email
hengsun@um.edu.mo
Consultation Hours

Mon, Thu 09:00 – 13:00, 14:30 – 17:45
Fri 09:00 – 13:00, 14:30 – 17:30

Teaching

HSCI2001 Cell and Molecular Biology Lab

Research Team
Name Position Office Phone Email
Ka U IPResearch AssistantN22-4034+853 8822 2903clementip@um.edu.mo
Education
PhD University of Chinese Academy of Sciences (2014)
BS Shandong Normal University (2007)
Position
2026 – Present Senior Instructor, Faculty of Health Sciences, University of Macau
2021 – 2026 Research Assistant Professor, Faculty of Health Sciences, University of Macau
Research Interests
Inter- and intra-tumor heterogeneity in breast cancers and mechanisms of breast cancer initiation, development, metastasis and anti-cancer drug resistance.
Representative Publications
  1. Heng Sun, Jianming Zeng, Zengqiang Miao, Kuan Cheok Lei, Chen Huang, Lingling Hu, Sek Man Su, Un In Chan, Kai Miao, Xu Zhang, Aiping Zhang, Sen Guo, Si Chen, Ya Meng, Min Deng, Wenhui Hao, Haipeng Lei, Ying Lin, Zhonglin Yang, Dongjiang Tang, Koon Ho Wong, Xiaohua Douglas Zhang, Xiaoling Xu, Chu-Xia Deng. Dissecting the heterogeneity and tumorigenesis of BRCA1 deficient mammary tumors via single cell RNA sequencing. Theranostics, 2021, 11(20): 9967-9987.
  2. Heng Sun, Zhengqiang Miao, Xin Zhang, Un In Chan, Sek Man Su, Sen Guo, Chris Koon Ho Wong, Xiaoling Xu, Chu-Xia Deng. Single-cell RNA-Seq reveals cell heterogeneity and hierarchy within mouse mammary epithelia. Journal of Biological Chemistry, 2018, 1;293(22):8315-8329.
  3. Xinyu Guo#, Heng Sun#, Feng Yu, Yangyang Feng, Sen Guo, Josh Haipeng Lei, Kai Miao, Ka-U Ip, Ling L, Hanghang Li, Xiaohong Liao, Xiaoling Xu, Rong Zhou, Chu-Xia Deng. Dasatinib Inhibits Basal B Breast Cancer Through ETS1-Mediated Extracellular Matrix Remodeling. Biomedicines. 2025 Nov 26;13(12):2888 (#, Co-first author).
  4. Ya Meng, Heng Sun*, Chu-Xia Deng*. Cancer can be a purely epigenetic disorder. Int J Biol Sci. 2025 Jan 6;21(3):955-957 (*, Co-corresponding author).
  5. Zehao Wu#, Heng Sun#, Zichen Xu, Kai Feng, Josh Haipeng Lei, Chu-Xia Deng, Qingsong Xu. Magnetically powered cancer cell microrobots for surgery-free generation of targeted tumor mouse models. Cell Reports Physical Science. 2024 (5) 9, 102182 (#, Co-first author).
  6. Zichen Xu#, Heng Sun#, Yuanhe Chen, Hon Ho Yu, Chu-Xia Deng, and Qingsong Xu. Bubble-Inspired Multifunctional Magnetic Microrobots for Integrated Multidimensional Targeted Biosensing. Nano Letters. 2024 24 (44), 13945-13954(#, Co-first author).
  7. Yilan Li#, Jingru Yan#, Heng Sun#, Yating Liang, Qianqian Zha, Shan Yu, Yao Zhang. Ferroptosis inhibitor alleviates sorafenib-induced cardiotoxicity by attenuating KLF11-mediated FSP1-dependent ferroptosis. Int J Biol Sci. 2024 Apr 22;20(7):2622-2639. doi: 10.7150/ijbs.86479 (#, Co-first author).
  8. Dongliang Leng#, Ziyi Yang#, Heng Sun#, Chengcheng Song, Chen Huang, Ka U Ip, Guokai Chen, Chu-Xia Deng, Xiaohua Douglas Zhang, Qi Zhao.Comprehensive analysis of tumor microenvironment reveals prognostic ceRNA network related to immune infiltration in sarcoma. Clin Cancer Res. 2023 Aug 1:CCR-22-3396. doi: 10.1158/1078-0432.CCR-22-3396. (#, Co-first author).
  9. Ya Meng*, Haitao Wang*, Xuebing Li*, Xinwei Wu*, Heng Sun*. Editorial: Immunity in the development of anti-cancer drug resistance. Front Pharmacol. 2022;13:1120037 (*, Co-corresponding author).
  10. Hailuan Zeng*, Xiaofan Lu*, Heng Sun*, Haitao Wang*. Editorial: Epigenetics of metabolism, immunology and aging. Front Genet. 2023;14:1135889 (*, Co-corresponding author).
  11. Heng Sun, Xin Zhang, Un In Chan, Sek Man Su, Sen Guo, Xiaoling Xu and Chu-Xia Deng. In vivo Mouse Mammary Gland Formation. Bio-protocol. 2020, 10(13): e3667.
  12. Heng Sun, Xiaoling Xu and Chu-Xia Deng. Preparation of Single Epithelial Cells Suspension from Mouse Mammary Glands. Bio-protocol. 2020, 10(04): e3530.
  13. Chen#, Heng Sun#, Kai Miao#, Chu-Xia Deng. CRISPR-Cas9: from Genome Editing to Cancer Research. International Journal of Biological Sciences, 2016, 12(12): 1427-1436 (#, Co-first author).
  14. Heng Sun, Xuebing Li, Li Fan, Guohao Wu, Min Li, Jing Fang. TRAF6 Is Upregulated in Colon Cancer and Promotes Proliferation of Colon Cancer Cells. Int J Biochem Cell Biol, 2014, Apr, 53:195-201.
  15. Heng Sun#, Xuebing Li#, Ya Meng, Li Fan, Min Li, Jing TRAF6 upregulates expression of HIF-1α and promotes tumor angiogenesis. Cancer Research, 2013, May, 73: 4950- 4959 (#, Co-first author).
  16. Heng Sun#, Xuebing Li#, Jing Hypoxia and tumors. Chinese Bulletin of Life Sciences, 2013, Feb, 25(2): 206-217 (#, Co-first author).
Full publications list
Research Grants
09/2025 – 09/2027 The Science and Technology Development Fund (FDCT), 0193/2024/AGJ
07/2022 – 07/2024 The Science and Technology Development Fund (FDCT), 0006/2021/AGJ
11/2021 – 11/2024 The Science and Technology Development Fund (FDCT), 0065/2021/A
01/2023 – 12/2024 Multi-Year Research Grant (MYRG) of University of Macau, MYRG2022-00175-FHS
01/2017 – 12/2019 National Natural Science Funding of China, 81602587