Kai MIAO

1. Shao F Y, Lyu X Y, Miao K, Xie L S, Wang H T, Xiao H, Li J, Chen Q, Ding R B, Chen P, Xing F Q, Zhang X, Luo G H, Zhu W, Cheng G, Lon N W, Martin S E, Wang G Y, Chen G K, Dai Y L, and Deng C X. Enhanced Protein Damage Clearance Induces Broad Drug Resistance in Multitype of Cancers Revealed by an Evolution Drug‐Resistant Model and Genome‐Wide siRNA Screening. Adv Sci. 2020; 7 (23): 2001914. Doi: 10.1002/advs.202001914.
2. Liu J L, Adhav R, Miao K, Su S M, Mo L H, Chan U I, Zhang X, Xu J, Li J J, Shu X D, Zeng J M, Zhang X, Lyu X, Pardeshi L, Tan K L, Sun H, Wong K H, Deng C X, and Xu X L. Characterization of BRCA1-deficient premalignant tissues and cancers identifies Plekha5 as a tumor metastasis suppressor. Nat Commun. 2020; 11 (1): 4875. PMID: 32978388
3. Miao K, Lei J H P, Valecha M V, Zhang A P, Xu J, Wang L J, Lyu X Y, Chen S, Miao Z Q, Zhang X, Su S M, Shao F Y, Rajendran B K, Bao J L, Zeng J M, Sun H, Chen P, Tan K L, Chen Q, Wong K H, Xu X L, and Deng C X. NOTCH1 activation compensates BRCA1 deficiency and promotes triple-negative breast cancer formation. Nat Commun. 2020; 11 (1): 3256. PMID: 32591500
4. Chen Q, Lei J H P, Bao J L, Wang H T, Hao W H, Li L, Peng C, Masuda T, Miao K, Xu J, Xu X L, and Deng C X. BRCA1 Deficiency Impairs Mitophagy and Promotes Inflammasome Activation and Mammary Tumor Metastasis. Adv Sci. 2020: 1903616. PMID: 32195105
5. Li Y, He Y, Miao K, Zheng Y, Deng C X, and Liu T M. Imaging of macrophage mitochondria dynamics in vivo reveals cellular activation phenotype for diagnosis. Theranostics. 2020; 10 (7): 2897-2917. PMID: 32194843
6. Xu X L, Chen E, Mo L H, Zhang L, Shao F Y, Miao K, Liu J L, Su S M, Valecha M, In Chan U, Zheng H P, Chen M, Chen W P, Chen Q, Fu H Q, Aladjem M I, and He Y Z. BRCA1 represses DNA replication initiation through antagonizing estrogen signaling and maintains genome stability in parallel with WEE1-MCM2 signaling during pregnancy. Hum Mol Genet. 2018; 28 (5): 842-857. PMID: 30445628
7. Zhu L P, Liu J, Zhou G Y, Ng H M, Ang I L, Ma G F, Liu Y B, Yang S, Zhang F J, Miao K, Poon T, Zhang X J, Yuan Z, Deng C X, and Zhao Q. Targeting immune checkpoint B7-H3 antibody-chlorin e6 bioconjugates for spectroscopic photoacoustic imaging and photodynamic therapy. Chem Commun. 2019; 55 (95): 14255-14258. PMID: 31657388
8. Hao D P, Li J J, Wang J L, Meng Y, Zhao Z Q, Zhang C, Miao K, Deng C X, Tsang B K, Wang L, and Di L J. Non-classical estrogen signaling in ovarian cancer improves chemo-sensitivity and patients outcome. Theranostics. 2019; 9 (13): 3952-3965. PMID: 31281524
9. Lahusen T, Kim S J, Miao K, Huang Z B, Xu X L, and Deng C X. BRCA1 function in the intra-S checkpoint is activated by acetylation via a pCAF/SIRT1 axis. Oncogene. 2018; 37 (17): 2343-2350. PMID: 29440709
10. Chen S, Sun H, Miao K, and Deng C X. CRISPR-Cas9: from Genome Editing to Cancer Research. Int J Biol Sci. 2016; 12 (12): 1427. PMID: 27994508

Representative publications of reproduction and development biology

11. Fu W, Yue Y, Miao K, Xi G, Zhang C, Wang W, An L, and Tian J. Repression of FGF signaling is responsible for Dnmt3b inhibition and impaired de novo DNA methylation during early development of in vitro fertilized embryos. Int J Biol Sci. 2020; 16 (15): 3085-3099. PMID: 33061820
12. Yang Q, Fu W, Wang Y, Miao K, Zhao H, Wang R, Guo M, Wang Z, Tian J, and An L. The proteome of IVF-induced aberrant embryo-maternal crosstalk by implantation stage in ewes. J Anim Sci Biotechnol. 2020; 11: 7. PMID: 31956410
13. Zhong H, Ren Z, Wang X, Miao K, Ni W, Meng Y, Lu L, Wang C, Liu W, Deng C X, Xu R H, and Chen G. Stagewise keratinocyte differentiation from human embryonic stem cells by defined signal transduction modulators. Int J Biol Sci. 2020; 16 (8): 1450-1462. PMID: 32210732
14. Miao K, Zhang X, Su S M, Zeng J, Huang Z, Chan U I, Xu X, and Deng C X. Optimizing CRISPR/Cas9 technology for precise correction of the Fgfr3-G374R mutation in achondroplasia in mice. J Biol Chem. 2019; 294 (4): 1142-1151. 30487289
15. Xi G, An L, Jia Z, Tan K, Zhang J, Wang Z, Zhang C, Miao K, Wu Z, and Tian J. Natriuretic peptide receptor 2 (NPR2) localized in bovine oocyte underlies a unique mechanism for C-type natriuretic peptide (CNP)-induced meiotic arrest. Theriogenology. 2018; 106: 198-209. PMID: 29080478
16. Ren L, Zhang C, Tao L, Hao J, Tan K, Miao K, Yu Y, Sui L, Wu Z, Tian J, and An L. High-resolution profiles of gene expression and DNA methylation highlight mitochondrial modifications during early embryonic development. J Reprod Dev. 2017; 63 (3): 247-261. PMID: 28367907
17. Tan K, Zhang Z, Miao K, Yu Y, Sui L, Tian J, and An L. Dynamic integrated analysis of DNA methylation and gene expression profiles in in vivo and in vitro fertilized mouse post-implantation extraembryonic and placental tissues. Mol Hum Reprod. 2016; 22 (7): 485-498. PMID: 27090932
18. Tan K, Wang X, Zhang Z, Miao K, Yu Y, An L, and Tian J. Downregulation of miR-199a-5p Disrupts the Developmental Potential of In Vitro-Fertilized Mouse Blastocysts. Biol Reprod. 2016; 95 (3): 54. PMID: 27488027
19. Tan K, An L, Miao K, Ren L, Hou Z, Tao L, Zhang Z, Wang X, Xia W, Liu J, Wang Z, Xi G, Gao S, Sui L, Zhu D S, Wang S, Wu Z, Bach I, Chen D B, and Tian J. Impaired imprinted X chromosome inactivation is responsible for the skewed sex ratio following in vitro fertilization. Proc Natl Acad Sci U S A. 2016; 113 (12): 3197-3202. PMID: 26951653
20. Wei X, Xiaoling Z, Kai M, Rui W, Jing X, Min G, Zhonghong W, Jianhui T, Xinyu Z, and Lei A. Characterization and comparative analyses of transcriptomes for in vivo and in vitro produced peri-implantation conceptuses and endometria from sheep. J Reprod Dev. 2016; 62 (3): 279-287. PMID: 26946921
21. Ren L, Wang Z, An L, Zhang Z, Tan K, Miao K, Tao L, Cheng L, Zhang Z, Yang M, Wu Z, and Tian J. Dynamic comparisons of high-resolution expression profiles highlighting mitochondria-related genes between in vivo and in vitro fertilized early mouse embryos. Hum Reprod. 2015; 30 (12): 2892-2911. PMID: 26385791
22. Zhao H, Sui L, Miao K, An L, Wang D, Hou Z, Wang R, Guo M, Wang Z, Xu J, Wu Z, and Tian J. Comparative analysis between endometrial proteomes of pregnant and non-pregnant ewes during the peri-implantation period. J Anim Sci Biotechnol. 2015; 6 (1): 18. PMID: 26023329
23. Tan K, An L, Wang S M, Wang X D, Zhang Z N, Miao K, Sui L L, He S Z, Nie J Z, Wu Z H, and Tian J H. Actin Disorganization Plays a Vital Role in Impaired Embryonic Development of In Vitro-Produced Mouse Preimplantation Embryos. PLoS One. 2015; 10 (6): e0130382. PMID: 26076347
24. Di K Q, Gao S, Cui L F, Chang G, Wu F J, Ren L K, An L, Miao K, Tan K, Tao L, Chen H, Wang Z L, Wang S M, Wu Z H, Gao S, Li X Y, and Tian J H. Generation of fully pluripotent female murine-induced pluripotent stem cells. Biol Reprod. 2015; 92 (5): 123. PMID: 25788660
25. Sui L, An L, Tan K, Wang Z, Wang S, Miao K, Ren L, Tao L, He S, Yu Y, Nie J, Liu Q, Xing L, Wu Z, Hou Z, and Tian J. Dynamic proteomic profiles of in vivo- and in vitro-produced mouse postimplantation extraembryonic tissues and placentas. Biol Reprod. 2014; 91 (6): 155. PMID: 25320150
26. Chang G, Gao S, Hou X, Xu Z, Liu Y, Kang L, Tao Y, Liu W, Huang B, Kou X, Chen J, An L, Miao K, Di K, Wang Z, Tan K, Cheng T, Cai T, Gao S, and Tian J. High-throughput sequencing reveals the disruption of methylation of imprinted gene in induced pluripotent stem cells. Cell Res. 2014; 24 (3): 293-306. PMID: 24381111

• Tian JH, Miao K, Guo M, Wu ZH, Wang XY, Wang C. Method of produce transgenic embryos and mice with low-titer lentivirus. (ZL 2009 1 0237357.0)
• Tian JH, Wu ZH, Miao K, Zhao HC, Wang R, Wang ZL. Culture Device. (ZL 2010 2 0504203.1)