2023-01-10T14:55:50+08:002019-11-29|
Contact Information
Title
Assistant Professor
Office
(Office) E12-4008 / (Lab) N22-4033
Phone
(Office) +853 8822 2903
Fax
+853 8822 2314
Email
kaimiao@um.edu.mo
Consultation Hours

Wed 16:00 – 17:00, Thu 10:00 – 11:00

Teaching

Course Outlines

HSCI2005 Biology of Development and Aging 

Research Team
Name Position Office Phone Email
Lijian WANGPhD Student (Lab Representative)N22-3007+853 8822 4132lijianwang@um.edu.mo
Hao LIUPhD Student
Jingxin ZHANGPhD Student
Wansheng SUNPhD Student
Education
DAg College of Animal Science and Technology, China Agricultural University (2013)
BSc Institute of Life Science and Technology, Hebei Normal University of Science & Technology (2007)
Position
2022 – Present Assistant Professor, Faculty of Health Sciences, University of Macau
2017 – 2022 Research Assistant Professor, Faculty of Health Sciences, University of Macau
2014 – 2017 Postdoctoral Fellow, Faculty of Health Sciences, University of Macau
Research Interests
Genome-wide screening and identification of genetic drivers that cooperate with mutant Brca1 in breast cancer progression and metastasis
Representative Publications
Representative publications of cancer research

  1. Shao F Y, Lyu X Y, Miao K, Xie L S, Wang H T, Xiao H, Li J, Chen Q, Ding R B, Chen P, Xing F Q, Zhang X, Luo G H, Zhu W, Cheng G, Lon N W, Martin S E, Wang G Y, Chen G K, Dai Y L, and Deng C X. Enhanced Protein Damage Clearance Induces Broad Drug Resistance in Multitype of Cancers Revealed by an Evolution Drug‐Resistant Model and Genome‐Wide siRNA Screening. Adv Sci. 2020; 7 (23): 2001914. Doi: 10.1002/advs.202001914.
  2. Liu J L, Adhav R, Miao K, Su S M, Mo L H, Chan U I, Zhang X, Xu J, Li J J, Shu X D, Zeng J M, Zhang X, Lyu X, Pardeshi L, Tan K L, Sun H, Wong K H, Deng C X, and Xu X L. Characterization of BRCA1-deficient premalignant tissues and cancers identifies Plekha5 as a tumor metastasis suppressor. Nat Commun. 2020; 11 (1): 4875. PMID: 32978388
  3. Miao K, Lei J H P, Valecha M V, Zhang A P, Xu J, Wang L J, Lyu X Y, Chen S, Miao Z Q, Zhang X, Su S M, Shao F Y, Rajendran B K, Bao J L, Zeng J M, Sun H, Chen P, Tan K L, Chen Q, Wong K H, Xu X L, and Deng C X. NOTCH1 activation compensates BRCA1 deficiency and promotes triple-negative breast cancer formation. Nat Commun. 2020; 11 (1): 3256. PMID: 32591500
  4. Chen Q, Lei J H P, Bao J L, Wang H T, Hao W H, Li L, Peng C, Masuda T, Miao K, Xu J, Xu X L, and Deng C X. BRCA1 Deficiency Impairs Mitophagy and Promotes Inflammasome Activation and Mammary Tumor Metastasis. Adv Sci. 2020: 1903616. PMID: 32195105
  5. Li Y, He Y, Miao K, Zheng Y, Deng C X, and Liu T M. Imaging of macrophage mitochondria dynamics in vivo reveals cellular activation phenotype for diagnosis. Theranostics. 2020; 10 (7): 2897-2917. PMID: 32194843
  6. Xu X L, Chen E, Mo L H, Zhang L, Shao F Y, Miao K, Liu J L, Su S M, Valecha M, In Chan U, Zheng H P, Chen M, Chen W P, Chen Q, Fu H Q, Aladjem M I, and He Y Z. BRCA1 represses DNA replication initiation through antagonizing estrogen signaling and maintains genome stability in parallel with WEE1-MCM2 signaling during pregnancy. Hum Mol Genet. 2018; 28 (5): 842-857. PMID: 30445628
  7. Zhu L P, Liu J, Zhou G Y, Ng H M, Ang I L, Ma G F, Liu Y B, Yang S, Zhang F J, Miao K, Poon T, Zhang X J, Yuan Z, Deng C X, and Zhao Q. Targeting immune checkpoint B7-H3 antibody-chlorin e6 bioconjugates for spectroscopic photoacoustic imaging and photodynamic therapy. Chem Commun. 2019; 55 (95): 14255-14258. PMID: 31657388
  8. Hao D P, Li J J, Wang J L, Meng Y, Zhao Z Q, Zhang C, Miao K, Deng C X, Tsang B K, Wang L, and Di L J. Non-classical estrogen signaling in ovarian cancer improves chemo-sensitivity and patients outcome. Theranostics. 2019; 9 (13): 3952-3965. PMID: 31281524
  9. Lahusen T, Kim S J, Miao K, Huang Z B, Xu X L, and Deng C X. BRCA1 function in the intra-S checkpoint is activated by acetylation via a pCAF/SIRT1 axis. Oncogene. 2018; 37 (17): 2343-2350. PMID: 29440709
  10. Chen S, Sun H, Miao K, and Deng C X. CRISPR-Cas9: from Genome Editing to Cancer Research. Int J Biol Sci. 2016; 12 (12): 1427. PMID: 27994508

Representative publications of reproduction and development biology

  1. Fu W, Yue Y, Miao K, Xi G, Zhang C, Wang W, An L, and Tian J. Repression of FGF signaling is responsible for Dnmt3b inhibition and impaired de novo DNA methylation during early development of in vitro fertilized embryos. Int J Biol Sci. 2020; 16 (15): 3085-3099. PMID: 33061820
  2. Yang Q, Fu W, Wang Y, Miao K, Zhao H, Wang R, Guo M, Wang Z, Tian J, and An L. The proteome of IVF-induced aberrant embryo-maternal crosstalk by implantation stage in ewes. J Anim Sci Biotechnol. 2020; 11: 7. PMID: 31956410
  3. Zhong H, Ren Z, Wang X, Miao K, Ni W, Meng Y, Lu L, Wang C, Liu W, Deng C X, Xu R H, and Chen G. Stagewise keratinocyte differentiation from human embryonic stem cells by defined signal transduction modulators. Int J Biol Sci. 2020; 16 (8): 1450-1462. PMID: 32210732
  4. Miao K, Zhang X, Su S M, Zeng J, Huang Z, Chan U I, Xu X, and Deng C X. Optimizing CRISPR/Cas9 technology for precise correction of the Fgfr3-G374R mutation in achondroplasia in mice. J Biol Chem. 2019; 294 (4): 1142-1151. 30487289
  5. Xi G, An L, Jia Z, Tan K, Zhang J, Wang Z, Zhang C, Miao K, Wu Z, and Tian J. Natriuretic peptide receptor 2 (NPR2) localized in bovine oocyte underlies a unique mechanism for C-type natriuretic peptide (CNP)-induced meiotic arrest. Theriogenology. 2018; 106: 198-209. PMID: 29080478
  6. Ren L, Zhang C, Tao L, Hao J, Tan K, Miao K, Yu Y, Sui L, Wu Z, Tian J, and An L. High-resolution profiles of gene expression and DNA methylation highlight mitochondrial modifications during early embryonic development. J Reprod Dev. 2017; 63 (3): 247-261. PMID: 28367907
  7. Tan K, Zhang Z, Miao K, Yu Y, Sui L, Tian J, and An L. Dynamic integrated analysis of DNA methylation and gene expression profiles in in vivo and in vitro fertilized mouse post-implantation extraembryonic and placental tissues. Mol Hum Reprod. 2016; 22 (7): 485-498. PMID: 27090932
  8. Tan K, Wang X, Zhang Z, Miao K, Yu Y, An L, and Tian J. Downregulation of miR-199a-5p Disrupts the Developmental Potential of In Vitro-Fertilized Mouse Blastocysts. Biol Reprod. 2016; 95 (3): 54. PMID: 27488027
  9. Tan K, An L, Miao K, Ren L, Hou Z, Tao L, Zhang Z, Wang X, Xia W, Liu J, Wang Z, Xi G, Gao S, Sui L, Zhu D S, Wang S, Wu Z, Bach I, Chen D B, and Tian J. Impaired imprinted X chromosome inactivation is responsible for the skewed sex ratio following in vitro fertilization. Proc Natl Acad Sci U S A. 2016; 113 (12): 3197-3202. PMID: 26951653
  10. Wei X, Xiaoling Z, Kai M, Rui W, Jing X, Min G, Zhonghong W, Jianhui T, Xinyu Z, and Lei A. Characterization and comparative analyses of transcriptomes for in vivo and in vitro produced peri-implantation conceptuses and endometria from sheep. J Reprod Dev. 2016; 62 (3): 279-287. PMID: 26946921
  11. Ren L, Wang Z, An L, Zhang Z, Tan K, Miao K, Tao L, Cheng L, Zhang Z, Yang M, Wu Z, and Tian J. Dynamic comparisons of high-resolution expression profiles highlighting mitochondria-related genes between in vivo and in vitro fertilized early mouse embryos. Hum Reprod. 2015; 30 (12): 2892-2911. PMID: 26385791
  12. Zhao H, Sui L, Miao K, An L, Wang D, Hou Z, Wang R, Guo M, Wang Z, Xu J, Wu Z, and Tian J. Comparative analysis between endometrial proteomes of pregnant and non-pregnant ewes during the peri-implantation period. J Anim Sci Biotechnol. 2015; 6 (1): 18. PMID: 26023329
  13. Tan K, An L, Wang S M, Wang X D, Zhang Z N, Miao K, Sui L L, He S Z, Nie J Z, Wu Z H, and Tian J H. Actin Disorganization Plays a Vital Role in Impaired Embryonic Development of In Vitro-Produced Mouse Preimplantation Embryos. PLoS One. 2015; 10 (6): e0130382. PMID: 26076347
  14. Di K Q, Gao S, Cui L F, Chang G, Wu F J, Ren L K, An L, Miao K, Tan K, Tao L, Chen H, Wang Z L, Wang S M, Wu Z H, Gao S, Li X Y, and Tian J H. Generation of fully pluripotent female murine-induced pluripotent stem cells. Biol Reprod. 2015; 92 (5): 123. PMID: 25788660
  15. Sui L, An L, Tan K, Wang Z, Wang S, Miao K, Ren L, Tao L, He S, Yu Y, Nie J, Liu Q, Xing L, Wu Z, Hou Z, and Tian J. Dynamic proteomic profiles of in vivo- and in vitro-produced mouse postimplantation extraembryonic tissues and placentas. Biol Reprod. 2014; 91 (6): 155. PMID: 25320150
  16. Chang G, Gao S, Hou X, Xu Z, Liu Y, Kang L, Tao Y, Liu W, Huang B, Kou X, Chen J, An L, Miao K, Di K, Wang Z, Tan K, Cheng T, Cai T, Gao S, and Tian J. High-throughput sequencing reveals the disruption of methylation of imprinted gene in induced pluripotent stem cells. Cell Res. 2014; 24 (3): 293-306. PMID: 24381111
Full publications list
Research Grants
2018 University of Macau Multi-Year Research Grant (MYRG), MYRG2018-00186-FHS, Mechanistic study of oncogenic drivers NOTCH1 and c-MET as well as the targeted therapy for BRCA1 associated breast cancer.
2017 Macau Science and Technology Development Fund (FDCT), 111/2017/A, Investigation of functional relevance of Cul5 cluster genes in breast cancer formation.
Patents
  • Tian JH, Miao K, Guo M, Wu ZH, Wang XY, Wang C. Method of produce transgenic embryos and mice with low-titer lentivirus. (ZL 2009 1 0237357.0)
  • Tian JH, Wu ZH, Miao K, Zhao HC, Wang R, Wang ZL. Culture Device. (ZL 2010 2 0504203.1)
Awards
2011 Alpharma Scholarship Award
2010 Excellent Paper Award of Chinese Association of Animal Science and Veterinary Medicine, CAAV
2010 Scholarship Award for Excellent Doctoral Student granted by Ministry of Education