Prof Ningyi SHAO

Education
DSc	Chinese Academy of Sciences (2006 – 2011)
BMed	Nanjing Medical University (1997 – 2002)

Position
2024 – Present	Associate Professor, Faculty of Health Sciences, University of Macau
2019 – 2024	Assistant Professor, Faculty of Health Sciences, University of Macau
2018 – 2019	Instructor, Stanford University
2014 – 2018	Postdoctoral fellow, Stanford University
2012 – 2014	Postdoctoral fellow, Icahn School of Medicine at Mount Sinai, New York
2011 – 2012	Research assistant, CAS-MPG Partner Institute for Computational Biology
2002 – 2006	Resident, Nanjing DrumTower Hospital affiliated to Nanjing University School of Medicine

Research Interests

My research interests focus on the translational equivalency of model animals to human development and diseases, and the multi-omics integration analysis of human development and diseases. Heart disease is the top adult killer in the Western world and bringing a considerable health burden to the society and individuals. Understanding how the heart works from the building blocks to the whole building has clear importance not only for defining of the etiology of heart but also for discovering novel regeneration strategies to treat heart disease. Recently with the application of next generation sequencing (NGS), the bottleneck of the biomedical studies transferred from data generation to data analysis. Effectively integrating large-scale data analysis with “wet” biology is the essential way to investigate the whole system from the building bricks. I am working on the integration of genome, transcriptome, and epigenome of human and mouse to investigate the development and related diseases in human.

Representative Publications

Lee, J.#, Shao, N.-Y.# et al. Essential Roles of SETD7 as Transcriptional Activator and Co-regulator of H3K36me in Cardiac Lineage Commitment. Cell Stem Cell(2018), http://dx.doi.org/10.1016/j.stem. 2018.02.005. Gu, M.#, Shao, N.-Y.# et al. iPSCs Reveal Protective Modifiers of the BMPR2 mutation in Pulmonary Arterial Hypertension. Cell Stem Cell (2016), http://dx.doi.org/10.1016/j.stem.2016.08.019. Zhao, M.#, Shao, N.-Y.# et al. Cell Type-Specific Chromatin Signatures Underline Regulatory DNA Elements in Human Induced Pluripotent Stem Cells and Somatic Cells. Circulation Research (2017), http://dx.doi.org/10.1161/CIRCRESAHA.117.311367. Shao, N.-Y. et al. Comprehensive survey of human brain microRNA by deep sequencing. BMC Genomics 11, 409 (2010). Shen, L.#, Shao, N.-Y.#, et al. ngs.plot: Quick mining and visualization of next-generation sequencing data by integrating genomic databases. BMC Genomics 15, 284 (2014). Shen, L., Shao, N.-Y., et al. diffReps: detecting differential chromatin modification sites from ChIP-seq data with biological replicates. PLoS ONE (2013). Feng, J., Shao, N.-Y., et al. Role of Tet1 and 5-hydroxymethylcytosine in cocaine action. Nat. Neurosci. 18, 536–544 (2015). Ferguson, D., Shao, N.-Y., et al. SIRT1-FOXO3a Regulate Cocaine Actions in the Nucleus Accumbens. J. Neurosci. 35, 3100–3111 (2015). Yuan, K., Shao, N.-Y., et al. Increased Pyruvate Dehydrogenase Kinase 4 Expression in Lung Pericytes Is Associated with Reduced Endothelial-Pericyte Interactions and Small Vessel Loss in Pulmonary Arterial Hypertension. Am. J. Pathol. 0, (2016). Dias, C., Feng, J., Sun, H., Shao, N.-Y., et al. β-catenin mediates stress resilience through Dicer1/microRNA regulation. Nature (2014). doi:10.1038/nature13976.

Awards
2018	Career Development Award: American Heart Association