Prof Qihan CHEN

1. 2’-O-methylation detection platform and exploration of its mechanisms.
2. Screen, early-stage diagnosis and prognosis of cancers.
3. Development of novel anti-bacteria peptides and anti-virus proteins.
4. Functional and evolutionary roles of synonymous mutations.
5. Other useful clinical applications.

1. Zichen Jiao, Xiaoqiang Zhang, Yulong Xuan, Xiaoming Shi, Zirui Zhang, Ao Yu, Ningyou Li, Shanshan Yang, Xiaofeng He, Gefei Zhao, Ruowei Yang, Jianqun Chen, Xuxiaochen Wu, Hua Bao, Fufeng Wang, Wei Ren(*), Hongwei Liang(*), Qihan Chen(*), Tao Wang(*).  Leveraging cfDNA fragmentomic features in a stacked ensemble model for early detection of esophageal squamous cell carcinoma, Cell Reports Medicine, 2024, 5, 101664
2. Rong Yang, Heng Zhang, Si Chen, Kaibin Lou, Meng Zhou, Mingchao Zhang, Rui Lu, Chunxia Zheng, Limin Li, Qihan Chen, Zhihong Liu(*), Ke Zen(*), Yanggang Yuan(*), Hongwei Liang(*). Quantification of urinary podocyte-derived migrasomes for the diagnosis of kidney disease. Journal of Extracellular Vesicles, 2024, volume 13, issue 6
3. Yao Tang, Yifan Wu, Sainan Wang, Xiaolan Lu, Xiangwen Gu, Yong Li, Fan Yang, Ruilin Xu, Tao Wang, Zichen Jiao, Yan Wu, Liwei Liu, Jian-Qun Chen(*), Qiang Wang(*), Qihan Chen(*). An integrative platform for detection of RNA 2′-O-methylation reveals its broad distribution on mRNA. Cell Reports Methods, 2024, volume 4, issue 3, 100721.
4. Lu X.; Gu X.; Li Y.; Wu Y.; Wang Q.; Yu W.; Chen Q.(*), Biochemical characterization of RNase R 2’-O-methylation sensitivity, Biochimie, 2023:04016.
5. Liang N.; Jiao Z.; Zhang C.; Wu Y.; Wang T; Song T.; Liang H.(*); Chen Q.(*), Mature Red Blood Cells contain long DNA fragments and could acquire DNA from Lung Cancer Tissue, Advanced Science, 2023:2206361.
6. Wang Y.; Liang X.; Jiang Y.; Dong D.; Zhang C.; Song T.; Chen M.; You Y.; Liu H.; Ge M.; Dai H.; Xi F.; Zhou W.; Chen J.; Wang Q.; Chen Q.(*); Yu W(*),Novel fast pathogen diagnosis method for severe pneumonia patients in the intensive care unit: randomized clinical trial, eLife, 2022, 11: e79014.
7. Wu, Y.; Song, T.; Chen, P.; Jiang, X.; Wang, Q.; Chen Q.(*). Prolonged siRNA expression in mammalian cells using an Epstein–Barr virus-based plasmid expression system. Biochemical and biophysical research communications, 2020, 529(1), 51-56.
8. Guo W.; Zhu L.; Yu M.; Chen Q.; Chen J.(*); Wang Q.(*), A four- DNA methylation biomarker is a superior predictor of survival of patients with cutaneous melanoma, eLife, 2019, 8: 0-e44310.
9. Guo W.; Zhu L.; Yu M.; Zhu R.; Chen Q.(*); Wang Q.(*), A five-DNA methylation signature act as a novel prognostic biomarker in patients with ovarian serous cystadenocarcinoma, Clinical Epigenetics, 2018.11.16, 10: 0~142.
10. Chen Q.; Xiao X.; Wolfe A.; Chen X. S., The in vitro Biochemical Characterization of an HIV-1 Restriction Factor APOBEC3F: Importance of Loop 7 on Both CD1 and CD2 for DNA Binding and Deamination, Journal of Molecular Biology, 2016, 428(13): 2661~70.
11. Gu J.; Chen Q.; Xiao X.; Ito F.; Wolfe A.; Chen X. S., Biochemical Characterization of APOBEC3H Variants: Implications for Their HIV-1 Restriction Activity and mC Modification, Journal of Molecular Biology, 2016, 428(23): 4626~4638.
12. Chen Q.; Han Z.; Jiang H.; Tian D.; Yang S., Strong positive selection drives rapid diversification of R-genes in Arabidopsis relatives, Journal of Molecular Evolution, 2010, 70(2): 137~48.

Early diagnosis of eclampsia in pregnant women

The development of RNA 2 ‘- O-methylation detection tools and biological significance exploration