2023-10-25T12:24:07+08:002023-10-19|
Contact Information
Title
Assistant Professor
Office
(Office) E12-2009
Email
lyonchen@um.edu.mo
Teaching
Education
PhD University of Southern California, United States (2016)
BSc Nanjing University, China (2010)
Position
10/2023 – Present Assistant Professor, Faculty of Health Sciences, University of Macau
04/2020 – 08/2023 Research Fellow, Medical School, Nanjing University, Nanjing, China
08/2017 – 04/2020 Research Fellow, School of Life Sciences, Nanjing University, Nanjing, China
Research Interests
  1. 2’-O-methylation detection platform and exploration of its mechanisms.
  2. Screen, early-stage diagnosis and prognosis of cancers.
  3. Development of novel anti-bacteria peptides and anti-virus proteins.
  4. Functional and evolutionary roles of synonymous mutations.
  5. Other useful clinical applications.
Representative Publications
  1. Lu X.; Gu X.; Li Y.; Wu Y.; Wang Q.; Yu W.; Chen Q.(*), Biochemical characterization of RNase R 2’-O-methylation sensitivity, Biochimie, 2023:04016.
  2. Liang N.; Jiao Z.; Zhang C.; Wu Y.; Wang T; Song T.; Liang H.(*); Chen Q.(*), Mature Red Blood Cells contain long DNA fragments and could acquire DNA from Lung Cancer Tissue, Advanced Science, 2023:2206361.
  3. Wang Y.; Liang X.; Jiang Y.; Dong D.; Zhang C.; Song T.; Chen M.; You Y.; Liu H.; Ge M.; Dai H.; Xi F.; Zhou W.; Chen J.; Wang Q.; Chen Q.(*); Yu W(*),Novel fast pathogen diagnosis method for severe pneumonia patients in the intensive care unit: randomized clinical trial, eLife, 2022, 11: e79014.
  4. Wu, Y.; Song, T.; Chen, P.; Jiang, X.; Wang, Q.; Chen Q.(*). Prolonged siRNA expression in mammalian cells using an Epstein–Barr virus-based plasmid expression system. Biochemical and biophysical research communications, 2020, 529(1), 51-56.
  5. Guo W.; Zhu L.; Yu M.; Chen Q.; Chen J.(*); Wang Q.(*), A four- DNA methylation biomarker is a superior predictor of survival of patients with cutaneous melanoma, eLife, 2019, 8: 0-e44310.
  6. Guo W.; Zhu L.; Yu M.; Zhu R.; Chen Q.(*); Wang Q.(*), A five-DNA methylation signature act as a novel prognostic biomarker in patients with ovarian serous cystadenocarcinoma, Clinical Epigenetics, 2018.11.16, 10: 0~142.
  7. Chen Q.; Xiao X.; Wolfe A.; Chen X. S., The in vitro Biochemical Characterization of an HIV-1 Restriction Factor APOBEC3F: Importance of Loop 7 on Both CD1 and CD2 for DNA Binding and Deamination, Journal of Molecular Biology, 2016, 428(13): 2661~70.
  8. Gu J.; Chen Q.; Xiao X.; Ito F.; Wolfe A.; Chen X. S., Biochemical Characterization of APOBEC3H Variants: Implications for Their HIV-1 Restriction Activity and mC Modification, Journal of Molecular Biology, 2016, 428(23): 4626~4638.
  9. Chen Q.; Han Z.; Jiang H.; Tian D.; Yang S., Strong positive selection drives rapid diversification of R-genes in Arabidopsis relatives, Journal of Molecular Evolution, 2010, 70(2): 137~48.

 

Research Grants
01/2022 – 12/2024 National Key R&D Program of China (2021YFC2701603):

Early diagnosis of eclampsia in pregnant women
01/2021 – 12/2023 Fundamental Research Funds for the Central Universities (021414380507):

The development of RNA 2 ‘- O-methylation detection tools and biological significance exploration
01/2019 – 12/2021 National
Natural Science Foundation of China (31801065):
Research on the role of non-CpG methylation of PGC-1α promoter region in the formation of insulin resistance in type 2 diabetes
01/2018 – 12/2019 National
Natural Science Foundation of China:Research on the regulation of gene expression by non-CpG type DNA methylation in promoter regions in neural cells
01/2018 – 12/2019 The fund Project of China for oversea returning brains:
The development and application of rapid detection technology for pathogenic bacteria in ICU