Contact Information

Title
Assistant Professor
Office
(Office) E12-3028
/ (Lab) N22-3038
Phone
(Office) +853 8822 4933
/ (Lab) +853 8822 2950
Fax
+853 8822 2314
Email
Consultation Hours
Wed, Thu 11:00 – 12:00
Teaching
Research Team
Name | Position | Office | Phone | |
---|---|---|---|---|
Wenfei PAN | PhD Student (Lab Representative) | N22-3038 | +853 8822 2950 | |
Vladimir Meshcheryakov | Post-doctoral Fellow | N22-3038 | +853 8822 2950 | vladimirm@um.edu.mo |
Limei DENG | PhD Student | N22-3038 | +853 8822 2950 | |
Chengjian FAN | PhD Student | N22-3038 | +853 8822 2950 |
Education | |
PhD | Department of Chemistry and Biochemistry, University of California San Diego, USA (2011) |
MSc | Department of Chemistry and Biochemistry, University of California San Diego, USA (2008) |
BSc | Department of Chemistry and Biochemistry, University of California San Diego, USA (2005) |
Positions | |
2016.8-present | Assistant Professor, Faculty of Health Sciences, University of Macau |
2015.9-2016.8 | Visiting Assistant Professor, Faculty of Health Sciences, University of Macau |
2015.3-2015.8 | Visiting Scientist, Department of Chemistry and Biochemistry, University of California San Diego, USA |
2012.9-2015.3 | Postdoc Research Fellow, Department of Biological Sciences, Columbia University, New York, USA |
2011.7-2012.9 | Postdoc Research Fellow, Department of Chemistry and Biochemistry, University of California San Diego, USA |
Research Interests |
In this laboratory we use our knowledge and experience in the area of biochemistry, structural biology, cellular and molecular biology to study the functions and mechanisms of important molecules focusing on their biological functions. The major focus of the current research involves understanding the signal transduction mediated by the nuclear factor kappaB (NF-kB) and IkB proteins. The mammalian Rel/NF-kB family of transcription factors plays a critical role in diverse physiological processes including the immune response, inflammation, cell proliferation and survival. A wide variety of signals activate NF-kB driven gene expression through different NF-kB signaling pathways in a stimulus- and cell type-dependent manner. Due to the diverse regulatory mechanisms acting on NF-kB, the signal dependent activation of NF-kB remains a challenging area of research. Using both biochemical and structural approaches, we will determine how post-translational modifications, e.g. phosphorylation, affect NF-kB:IkB:DNA complex formation, binding specificity, and target gene expression. |
Representative Publications |
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Research Grants |
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