Contact Information

Title
Associate Professor
Office
(Office) E12-3026
/ (Lab) N22-4003
Phone
(Office) +853 8822 4908
/ (Lab) +853 8822 2934
Fax
+853 8822 2314
Consultation Hours
Tue, Fri 14:15 – 15:15
Teaching
Research Team
Name | Position | Office | Phone | |
---|---|---|---|---|
Qiuyun YAN | PhD Student (Lab Representative) | N22-4003 | +853 8822 2934 | yc17602@um.edu.mo |
Haoweng WU | PhD Student | N22-4003 | +853 8822 2934 | |
Huadong LI | PhD Student | N22-4003 | +853 8822 2934 | |
Meilin WANG | PhD Student | N22-4003 | +853 8822 2934 |
Education | |
PhD | The Institute of Cancer Research, University of London, United Kingdom (2011) |
MBiochem | Molecular and Cellular Biochemistry, St Peter’s College, University of Oxford, United Kingdom (2007) |
Position | |
09/2017 – Present | Associate Professor, Faculty of Health Sciences, University of Macau |
2012 – 2017 | Cancer Research UK Additional Quota Fellow, London Research Institute / The Francis Crick Institute, London |
2011 – 2012 | Postdoctoral Fellow, The Institute of Cancer Research, London |
Research Interests |
The remarkable accuracy of eukaryotic cell division is maintained by the cohesin-mediated entrapment of sister chromatids. The topological entrapment of DNA relies on the opening of the cohesin ring, which is stimulated by the Scc2-Scc4 loader complex.A substantial amount of genetic and biochemical data has recently been generated to help explain the cohesin ring opening mechanism. Yet there is still much debate about the exact region in cohesin for DNA to enter. Most importantly, the structural information that can define the molecular gymnastics of how Scc2-Scc4 opens the cohesin ring is still missing.
To obtain such important information, my laboratory will apply X-ray crystallography and cryo-electron microscopy (cryo-EM) to determine the structures of cohesin-regulator complexes with the aim to understand the cohesin ring opening mechanism. The acquired knowledge will allow the cancer research community to rationalise oncogenic protein mutations, potentially contributing to the understanding of cancer and other hereditary diseases. |
Representative Publications |
|
Awards | |
2012 | Cancer Research UK Additional Quota Fellowship, London Research Institute, London, United Kingdom |
2012 | Chairman’s Prize for Best PhD Student 2011, The Institute of Cancer Research, London, United Kingdom |
Grants | |
01/2019 – 12/2021 | Structural studies of the cohesin ring opening mechanism (MYRG2018-00221-FHS) |
10/2018 – 10/2021 | Structural studies of circadian clock and cell cycle coupling via the Timeless protein (FDCT 0009/2018/A1) |