Contact Information
Address(Office)N22-4034
(Lab)N22-4033
Phone(Office)8822 2903
(Lab)
Fax8822 2314
Emailkaimiao@um.edu.mo
Education
Ph.D.2013College of Animal Science and Technology, China Agricultural University
B.S.2007Institute of Life Science and Technology, Hebei Normal University of Science & Technology
Position
2017-PresentResearch Assistant Professor, Faculty of Health Sciences, University of Macau
2014-2017Postdoctoral Fellow, Faculty of Health Sciences, University of Macau
Research Interests
Genome-wide screening and identification of genetic drivers that cooperate with mutant Brca1 in breast cancer progression and metastasis
Representative Publications
  • Kai Miao, Xin Zhang, Sek Man Su, Jianming Zeng, Zebin Huang, Un In Chan, Xiaoling Xu, Chu-Xia Deng, Optimizing CRISPR/Cas9 technology for precise correction of the Fgfr3-G374R mutation in achondroplasia in mice, J Biol Chem. 2019 Jan 25;294(4):1142-1151
  • Xiaoling Xu, Eric Chen, Lihua Mo, Lei Zhang, Fangyuan Shao, Kai Miao, Jianlin Liu, Sek Man Su, Monica Valecha, Un In Chan, Hongping Zheng, Mark Chen, Weiping Chen, Qiang Chen, Haiqing Fu, Mirit I Aladjem, Yanzhen He, Chu-Xia Deng, BRCA1 represses DNA replication initiation through antagonizing estrogen signaling and maintains genome stability in parallel with WEE1–MCM2 signaling during pregnancy, Hum Mol Genet. 2019 Mar 1;28(5):842-857
  • Tyler J Lahusen, Seung-Jin Kim, Kai Miao, Zebin Huang, Xiaoling Xu, Chu-Xia Deng, BRCA1 function in the intra-S checkpoint is activated by acetylation via a pCAF/SIRT1 axis, Oncogene. 2018 Apr;37(17):2343-2350
  • Guangyin Xi, Lei An, Zhenwei Jia, Kun Tan, Jiaxin Zhang, Zhuqing Wang, Chao Zhang, Kai Miao, Zhonghong Wu, Jianhui Tian, Natriuretic peptide receptor 2 (NPR2) localized in bovine oocyte underlies a unique mechanism for C-type natriuretic peptide (CNP)-induced meiotic arrest, Theriogenology. 2018 Jan 15;106:198-209
  • Likun REN, Chao ZHANG, Li TAO, Jing HAO, Kun TAN, Kai MIAO, Yong YU, Linlin SUI, Zhonghong WU, Jianhui TIAN, Lei AN, High-resolution profiles of gene expression and DNA methylation highlight mitochondrial modifications during early embryonic development, J Reprod Dev. 2017 Jun 21;63(3):247-261
  • Si Chen*, Heng Sun*, Kai Miao*, Chu-Xia Deng, CRISPR-Cas9: from Genome Editing to Cancer Research, Int J Biol Sci 2016; 12(12):1427-1436 (*They contributed equally to this work)
  • Kun Tan*, Lei An*, Kai Miao*, Likun Ren, Zhuocheng Hou, Li Tao, Zhenni Zhang, Xiaodong Wang, Wei Xia, Jinghao Liu, Zhuqing Wang, Guangyin Xi, Shuai Gao, Linlin Sui, Desheng Zhu, Shumin Wang, Zhonghong Wu, Ingolf Batch, Dong-bao Chen, Jianhui Tian, Impaired imprinted X-chromosome inactivation is responsible for the skewed sex ratio following in vitro fertilization, Proc Natl Acad Sci U S A. 2016 Mar 22;113(12):3197-202 (*They contributed equally to this work)
  • Kun Tan, Zhenni Zhang, Kai Miao, Yong Yu, Linlin Sui, Jianhui Tian and Lei An, Dynamic integrated analysis of DNA methylation and gene expression profiles in in vivo and in vitro fertilized mouse post-implantation extraembryonic and placental tissues, Mol Hum Reprod. 2016 Jul;22(7):485-98
  • Kun Tan, Xiaodong Wang, Zhenni Zhang, Kai Miao, Yong Yu, Lei An2, and Jianhui Tian, Downregulation of miR-199a-5p Disrupts the Developmental Potential of In Vitro-Fertilized Mouse Blastocysts, Biol Reprod. 2016 Sep;95(3):54
  • Xia Wei, Zhang Xiaoling, Miao Kai, Wang Rui, Xu Jing, Guo Mim, Wu Zhonghong, Tian Jianhui, Zhang Xxinyu, An Lei, Characterization and comparative analyses of transcriptomes for in vivo and in vitro produced peri-implantation conceptuses and endometria from sheep, J Reprod Dev. 2016 Jun 17;62(3):279-87
  • Kun Tan, Lei An, Shu-Min Wang, Xiao-Dong Wang, Zhen-Ni Zhang, Kai Miao, Lin-Lin Sui, Shu-Zhi He, Jing-Zhou Nie, Zhong-Hong Wu, Jian-Hui Tian, Actin Disorganization Plays a Vital Role in Impaired Embryonic Development of In Vitro-Produced Mouse Preimplantation Embryos, PLoS One. 2015 Jun 15;10(6)
  • Ren Likun, Wang Zhuqing, An Lei, Zhang Zhennan, Tan Kun, Miao Kai, Tao Li, Cheng Linghua, Zhang Zhenni, Yang Mingyao, Wu Zhonghong, Tian Jianhui, Dynamic comparisons of high-resolution expression profiles highlighting mitochondria-related genes between in vivo and in vitro fertilized early mouse embryos, Human Reproduction, 2015, 30 (12) :2892-2911
  • Zhao Haichao, Sui Linlin, Miao Kai, An Lei, Wang Dong, Hou Zhuocheng, Wang Rui, Guo Min, Wang Zhilong, Xu Jiqiang, Wu Zhonghong, Tian Jianhui, Comparative analysis between endometrial proteomes of pregnant and non-pregnant ewes during the peri-implantation period., J Anim Sci Biotechnol, 2015, 6 (1) :18-18
  • Di Ke-Qian, Gao Shuai, Cui Li-Fang, Chang Gang, Wu Fu-Jia, Ren Li-Kun, An Lei, Miao Kai, Tan Kun, Tao Li, Chen Hui, Wang Zhi-Long, Wang Shu-Min, Wu Zhong-Hong, Gao Shaorong, Li Xiang-Yun, Tian Jian-Hui, Generation of fully pluripotent female murine-induced pluripotent stem cells., Biol Reprod, 2015, 92 (5) :123-123
  • Sui Linlin, An Lei, Tan Kun, Wang Zhuqing, Wang Shumin, Miao Kai, Ren Likun, Tao Li, He Shuzhi, Yu Yong, Nie Jinzhou, Liu Qian, Xing Lei, Wu Zhonghong, Hou Zhuocheng, Tian Jianhui, Dynamic proteomic profiles of in vivo- and in vitro-produced mouse postimplantation extraembryonic tissues and placentas., Biology of Reproduction, 2014, 91 (6) :155-155
  • Chang Gang, Gao Shuai, Hou Xinfeng, Xu Zijian, Liu Yanfeng, Kang Lan, Tao Yu, Liu Wenqiang, Huang Bo, Kou Xiaochen, Chen Jiayu, An Lei, Miao Kai, Di Keqian, Wang Zhilong, Tan Kun, Cheng Tao, Cai Tao, Gao Shaorong, Tian Jianhui, High-throughput sequencing reveals the disruption of methylation of imprinted gene in induced pluripotent stem cells., Cell Res, 2014, 24 (3) :293-306
  • Nie JH*, An L*, Miao K*, Hou ZC, Yu Y, Tan K, Sui LL, He SZ, Wu ZH, Tian JH. Comparative Analysis of Dynamic Proteomic Profiles between In Vivo In Vitro Produced Mouse Embryos during Post implantation. J Proteome Res, 2013, 12 (9) :3843-3856 (*They contributed equally to this work)
  • Lei An, Yun-Wei Pang, Hong-Mei Gao, Li Tao, Kai Miao, Zhong-Hong Wu, Jian-Hui Tian, Heterologous expression of C. elegans fat-1 decreases the n-6/n-3 fatty acid ratio and inhibits adipogenesis in 3T3-L1 cells, Biochemical and Biophysical Research Communications, 2012, 428 (3) :405-410
  • Ma Wenzhi, An Lei, Wu Zhonghong, Wang Xiaoying, Guo Min, Miao Kai, Ma Wei, Tian Jianhui, Efficient and safe recipient preparation for transplantation of mouse spermatogonial stem cells: pretreating testes with heat shock., Biol Reprod, 2011, 85 (4) :670-677
  • Miao K, Guo M, An L, Xu XL, Wu H, Wang D, Wu ZH, Tian JH. A new method to efficiently produce transgenic embryos and mice from low-titer lentiviral vectors. Transgenic Res. 2011, 20 (2) :357-363
Research Grants
  • Macau Science and Technology Development Fund (FDCT), 111/2017/A, 2017, Investigation of functional relevance of Cul5 cluster genes in breast cancer formation.
  • University of Macau Multi-Year Research Grant (MYRG), MYRG2018-00186-FHS, 2018, Mechanistic study of oncogenic drivers NOTCH1 and c-MET as well as the targeted therapy for BRCA1 associated breast cancer.
Patents
  • Tian JH, Miao K, Guo M, Wu ZH, Wang XY, Wang C. Method of produce transgenic embryos and mice with low-titer lentivirus. (ZL 2009 1 0237357.0)
  • Tian JH, Wu ZH, Miao K, Zhao HC, Wang R, Wang ZL. Culture Device. (ZL 2010 2 0504203.1)
Awards
  • 2010 Scholarship Award for Excellent Doctoral Student granted by Ministry of Education
  • 2010 Excellent Paper Award of Chinese Association of Animal Science and Veterinary Medicine, CAAV
  • 2011 Alpharma Scholarship Award