The 8th National Conference on Bioinformatics and Systems Biology of China and the 1st (Macao) International Bioinformatics Symposium, hosted by FHS, was held on 21-24 October. This hightly impactful symposium is held nationally every two years. This is the first time that the conference is held in Macau. Experts from the Chinese Academy of Sciences, Harvard University, University of Chicago, and many other highly-ranked institutions gathered here to discuss and present their research on bioinformatics and systems biology. This event attracted over 540 participants, with over 160 articles submissions, facilitating research and development of bioinformatics and systems biology in Macao.