|Critical Regulations of Cardiac Niche on Stem Cell Fate
|Prof. Xi-Yong YU
Dean of School of Pharmaceutical Sciences, Guangzhou Medical University
|Date & Time
|10 July 2018 (Tuesday) 15:00-16:00
|Room G004, E12 Building (University of Macau)
|Bone marrow mesenchymal stem cells (BMSCs) are stem cells from mesoderm period with potential of self-renewal and multiple differentiation, and are therefore popular in clinical application because of the low immunogenicity. However, most of the recent studies focused only on their paracrine function, and the ability of their direct differentiation into cardiomyocyte has always been controversial, leading to the failure of the direct BMSCs transplantation to develop its full potential. Cardiac progenitor cells (CPCs) is a kind of specific stem cells from heart tissue which besides the basic characteristics of normal stem cells, can also differentiate into three heart spectrum directly (including cardiomyocyte, endothelial cells and smooth muscle cells in the heart), and therefore acting as a good “stemness” source. Therefore, this study will focus on the differentiation efficiency of how BMSCs can be reprogrammed by the protein induction to generate CPCs.