Contact Information
Title
Associate Department Head, Associate Professor
Office
(Office) E12-3012
/ (Lab) E12-2071
Phone
(Office) +853 8822 4975
/ (Lab) +853 8822 9147
Fax
+853 8822 2902
Email
Consultation Hours
Wed 09:00 – 11:00
Research Team
Name | Position | Office | Phone | |
---|---|---|---|---|
Nancy ZHENG | Research Assistant | E12-3040 | nancyzheng@um.edu.mo | |
Jie KE | PhD Student | E12-3043 | ||
Shuai LIU | PhD Student | E12-3043 | ||
Wenqi ZHANG | PhD Student | E12-3043 | ||
Shiwen WANG | PhD Student | E12-3043 | ||
Qiaoyuan LIU | PhD Student | E12-3043 | ||
Zijian SUN | PhD Student | |||
Xi YANG | PhD Student |
Education | |
PhD
(2004 – 2009) |
University of Arizona, Tucson, Arizona, United States
PhD in Pharmacology and Toxicology |
BSc
(1996 – 2000) |
Sun Yat-Sen (Zhongshan) University, Guangzhou, China
BS in Microbiology |
Positions | |
2020 – Present | Associate Professor, Faculty of Health Sciences, University of Macau, Macao |
2014 – 2020 | Assistant Professor, Faculty of Health Sciences, University of Macau, Macao |
2009 – 2014 | Postdoctoral Research Fellow, UCSD Stem Cell Program, University of California San Diego, La Jolla, California, USA |
Research Interests |
Increasing evidence suggests that epigenetic regulation of chromatin states strongly influences gene expression and cell fate choices, and its deregulation could therefore be a critical aspect to development and disease. My research focuses on understanding how chromatin-modifying enzymes control cell fate decisions during pancreas development, and elucidating the epigenetic and transcriptional mechanisms that underlie pancreatic lesion. We utilized both mouse genetic approaches and a parallel hESC-based in vitro differentiation system which recapitulates the sequence of events observed during in vivo pancreas development, where pluripotent cells first commit to endoderm, then primitive gut tube, posterior foregut, and subsequently pancreas. Using this differentiation platform, we have begun to dissect the epigenetic events that drive pancreatic development. Additional ongoing research in my laboratory includes:
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Representative Publications |
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Research Grants | |
2020 – 2023 | The Science and Technology Development Fund, Macao S.A.R (FDCT 0022/2019/AMJ, $1,875,000, PI). Functions of post-translational modifications of key epigenetic and transcriptional regulatory factors in malignant tumor development. |
2020 – 2021 | University of Macau Multi-Year Research Grant (MYRG2019-00126-FHS, $126,000, PI). Anti-tumour effects of an ADAM17 inhibitory antibody on pancreatitis-induced pancreatic ductal adenocarcinoma. |
2019 – 2022 | The Science and Technology Development Fund, Macao S.A.R (FDCT 0033/2019/A1, $2,248,000, PI). The anti-inflammatory mechanisms of Prdm3 in pancreatitis and pancreatic ductal adenocarcinoma. |
2019 – 2020 | The Science and Technology Development Fund, Macao S.A.R (FDCT 0025/2019/PS, $126,724, PI). The development of a sustainable cyanobacteria system for endocrine disrupting compounds degradation. |
2018 – 2021 | The Science and Technology Development Fund, Macao S.A.R (FDCT 170/2017/A3, $1,385,000, PI). The roles of PRDM16 in pancreatic ductal adenocarcinoma. |
2018 – 2020 | National Natural Science Foundation of China (NSFC 31701276, $240,000, PI). Dissecting the roles of TET hydroxylates in enhancer priming during endoderm lineage specification. |
2017 – 2019 | University of Macau Multi-Year Research Grant (MYRG2016-00065-FHS, $1,500,000, PI). Developing multicellular pancreatic endoderm clusters for cell replacement therapies in diabetes. |
2014 – 2017 | University of Macau Start-up Research Grant (SRG2014-00030-FHS, $150,000, PI). The role of PRDMs in epigenetic regulation of pancreas development. |
Awards | |
2012 | Scholarship Award, Beta Cell Biology Consortium Investigator Retreat |
2011 | Scholarship Award, Beta Cell Biology Consortium Investigator Retreat |
2008 | Conference Grant, PARP 17th International Symposium on Poly(ADP-reibosyl)ation |
2008 | Finalist and honorable mention for Carl C. Smith Mechanisms Specialty Section manuscript award, Society of Toxicology Annual Meeting |
2007 | Drug Discovery Specialty Section Travel Award, Society of Toxicology Annual Meeting |
2006 | Graduate Student Travel Award, American Society for Pharmacology and Experimental Therapeutics |
Professional Activities | |
2014 – Present | American Association for Cancer Research |
2013 – Present | International Society for Stem Cell Research |
2020 – Present | Macau Society for Stem Cell Research |