Contact Information 
Phone(Office)8822 4881
(Lab)8822 2946
Fax8822 2314
Ph.D.Inorganic Chemistry, Changchun Institute of Applied Chemistry (CIAC), Chinese Academy of Sciences (CAS), China (2014)
B.Sc.Chemical Engineering and Technology, Harbin Engineering University, China (2009)
08/2018-presentAssistant Professor, Faculty of Health Sciences, University of Macau
09/2016-07/2018Postdoc Fellow, National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), USA
10/2014-09/2016Research Fellow, The University of Melbourne, Australia
06/2014-10/2014Lecturer, Harbin Engineering University, China
Research Interests
Our group research interest mainly focuses on the nanomaterials for targeted delivery of anticancer therapeutics and multimodal biological imaging (X-ray computed tomography, optical imaging, magnetic resonance imaging and photoacoustic imaging, etc). We aim to develop inorganic nanomaterials and nanoscale coordination materials for gene and drug delivery, immunotherapy and biological imaging. In particular, we are working on designing and preparing multi-functional nanomaterials for enhanced anticancer therapy by exploiting the tumor microenvironment. We are also developing promising nanodrugs for clinical translation.
Representative Publications

Google Scholar:

H-index: 38, a total citation of over 5,000 times based on Google Scholar

From University of Macau

  1. Wei Sang†, Zhan Zhang†, Yunlu Dai*(corresponding author), Xiaoyuan Chen* Recent Advances in Nanomaterials-based Synergistic Combination Cancer Immunotherapy. Chem. Soc. Rev., 2019, Advanced Article, DOI: 10.1039/C8CS00896E. (IF 40.182)
  2. Zhimei He, Xiaolin Huang, Chen Wang, Xiangli Li, Yijing Liu, Zijian Zhou, Sheng Wang, Fuwu Zhang, Zhantong Wang, Orit Jacobson, Jun-Jie Zhu,* Guocan Yu,* Yunlu Dai*(corresponding author), Xiaoyuan Chen* A Catalase-Like Metal-Organic Framework Nanohybrid for O2-Evolving Synergistic Chemoradiotherapy, Angew. Chem. Int. Ed. 2019, DOI: 10.1002/anie.201902612. (IF 12.102)
  3. Lingling Shan, Guizhen Gao, Weiwei Wang, Wei Tang, Zhantong Wang, Zhen Yang, Wenpei Fan, Guizhi Zhu, Kefeng Zhai, Orit Jacobson, Yunlu Dai*(corresponding author), Xiaoyuan Chen,* Self-assembled Green Tea Polyphenol-based Coordination Nanomaterials to Improve Chemotherapy Efficacy by Inhibition of Carbonyl Reductase 1. Biomaterials, 2019, 210, 62. (IF 8.806)
  4. Yuan Liu, Christina S. Gong, Lisen Lin, Zijian Zhou, Yijing Liu, Zhen Yang, Zheyu Shen, Guocan Yu, Zhantong Wang, Sheng Wang, Ying Ma, Wenpei Fan, Liangcan He, Gang Niu, Yunlu Dai*(corresponding author), Xiaoyuan Chen* Core-shell metal-organic frameworks with fluorescence switch to trigger an enhanced photodynamic therapy. Theranostics 2019, 9, 2791. (IF 8.712)
  5. Zhimei He†, Yunlu Dai†(co-first author), Xiangli Li, Dan Guo, Yijing Liu, Xiaolin Huang, Jingjing Jiang, Sheng Wang, Guizhi Zhu, Fuwu Zhang, Lisen Lin, Jun-Jie Zhu,* Guocan Yu,* Xiaoyuan Chen* Hybrid Nanomedicine Fabricated from Photosensitizer-Terminated Metal-Organic Framework Nanoparticles for Photodynamic Therapy and Hypoxia-Activated Cascade Chemotherapy. Small, 2019, 15, 1804131. (IF 9.598)
  6. Zhen Yang, Yunlu Dai*(corresponding author), Lingling Shan, Zheyu Shen, Zhantong Wang, Bryant C Yung, Orit Jacobson, Yijing Liu, Wei Tang, Sheng Wang, Lisen Lin, Gang Niu, Pintong Huang*, Xiaoyuan Chen* Tumour microenvironment-responsive semiconducting polymer-based self-assembling nanotheranostics, Nanoscale Horiz., 2019, 4, 426. (IF 9.391)

Prior to University of Macau

  1. Yunlu Dai, Zhen Yang, Siyuan Cheng, Zhongliang Wang,* Ruili Zhang, Guizhi Zhu, Zhantong Wang, Bryant C. Yung, Rui Tian, Orit Jacobson, Can Xu, Qianqian Ni, Jibin Song, Xiaolian Sun, Gang Niu, Xiaoyuan Chen,*. Toxic Reactive Oxygen Species Enhanced Synergistic Combination Therapy by Self-Assembled Metal-Phenolic Network Nanoparticles. Adv. Mater., 2018, 30, 1704877. (IF 21.950)
  2. Yunlu Dai, Siyuan Cheng, Zhongliang Wang,* Ruili Zhang, Zhen Yang, Jingjing Wang, Bryant C. Yung, Zhantong Wang, Orit Jacobson, Can Xu, Qianqian Ni, Guocan Yu, Zijian Zhou, and Xiaoyuan Chen,* Hypochlorous Acid Promoted Platinum Drug Chemotherapy by Myeloperoxidase Encapsulated Therapeutic Metal Phenolic Nanoparticles. ACS Nano, 2018, 12, 455. (IF 13.709)
  3. Zhen Yang,† Yunlu Dai†(co-first author), Chao Yin, Quli Fan,* Wansu Zhang, Guocan Yu, Wei Tang, Wenpei Fan, Jie Li, Xiang Li, Yufu Tang, Xiangchun Li, Jibin Song,* Wei Huang, Xiaoyuan Chen* Activatable Semiconducting Theranostics: Simultaneous Generation and Ratiometric Photoacoustic Imaging of Reactive Oxygen Species In Vivo Adv. Mater., 2018, 30, 1707509. (IF 21.950)
  4. Yunlu Dai, Can Xu, Xiaolian Sun* and Xiaoyuan Chen*. Nanoparticle design strategies for enhanced anticancer therapy by exploiting the tumour microenvironment. Chem. Soc. Rev., 2017, 46, 3830-3852. (IF 40.182)
  5. Yunlu Dai, Haihua Xiao, Jianhua Liu, Qinghai Yuan, Ping’an Ma, Dongmei Yang Chunxia Li, Zhiyao Hou, Ziyong Cheng, Piaoping Yang* and Jun Lin*. In Vivo Multimodal Imaging and Cancer Therapy by Near-Infrared Light Triggered Trans-platinum Pro-drug Conjugated Upconverison Nanoparticle. J. Am. Chem. Soc. 2013, 135, 18920-18929. (IF 14.375) (Hot paper)
  6. Yunlu Dai, Ping’an Ma, Ziyong Cheng*, Xiaojiao Kang, Xiao Zhang, Zhiyao Hou, Chunxia Li, Dongmei Yang, Xuefeng Zhai, Jun Lin*. Up-Conversion Cell Imaging and pH-Induced Thermally Controlled Drug Release from NaYF4:Yb3+/Er3+@Hydrogel Core-Shell Hybrid Microspheres. ACS Nano 2012, 6, 3327-3338. (IF 13.709)
  7. Huiting Bi†, Yunlu Dai†(co-first author), Piaoping Yang*, Jiating Xu, Dan Yang, Shili Gai, Fei He, Bin Liu, Chongna Zhong, and Jun Lin*. Glutathione Mediated Size-Tunable UCNPs-Pt(IV)-ZnFe2O4 Nanocomposite for Multiple Bioimaging Guided Synergetic Therapy. Small, 2018, 14, 1703809. (IF 9.598)
  8. Zhantong Wang†, Yunlu Dai†(co-first author), Zhe Wang*, Orit Jacobson, Fuwu Zhang, Bryant C. Yung, Pengfei Zhang, Haiyan Gao, Gang Niu, Gang Liu,*, Xiaoyuan Chen,* Metal Ion Assisted Interface Re-engineering of Ferritin Protein Nanocage for Enhanced Biofunctions and Cancer Therapy. Nanoscale, 2018, 10, 1135. (IF 7.233)
  9. Yunlu Dai, Cuimiao Zhang, Ziyong Cheng*, Ping’an Ma, Chunxia Li, Xiaojiao Kang, Dongmei Yang, Jun Lin*. pH-Responsive Drug Delivery System Based on Luminescent CaF2:Ce3+/Tb3+-Poly(acrylic acid) Hybrid Microspheres. Biomaterials 2012, 33, 2583-2592. (IF 8.806)
  10. Yunlu Dai, Dongmei Yang, Ping’an Ma, Xiaojiao Kang, Xiao Zhang, Chunxia Li, Zhiyao Hou, Ziyong Cheng,* Jun Lin*. Doxorubicin Conjugated NaYF4:Yb3+/Tm3+ Nanoparticles for Therapy and Sensing of Drug Delivery by Luminescence Resonance Energy Transfer. Biomaterials 2012, 33, 8704-8713. (IF 8.806)
  11. Yunlu Dai, Junling Guo, Ting‐Yi Wang, Yi Ju, Andrew J Mitchell, Thomas Bonnard, Jiwei Cui, Joseph J Richardson, Christoph E Hagemeyer, Karen Alt*, Frank Caruso*. Self‐Assembled Nanoparticles from Phenolic Derivatives for Cancer Therapy. Adv. Healthcare Mater. 2017, 6, 1700467. (IF 5.11)
  12. Yunlu Dai, Huiting Bi, Xiaoran Deng, Chunxia Li,* Fei He, Piaoping Yang,* Jun Lin*. 808 nm near-infrared light controlled dual-drug release and cancer therapy in vivo by upconversion mesoporous silica nanostructures J. Mater. Chem. B, 2017, 5, 2086-2095 (IF 4.776) (Hot paper)
  13. Huiting Bi, Yunlu Dai*(corresponding author), Jiating Xu, Ruichan Lv, Fei He, Shili Gai, Dan Yang, Piaoping Yang*. CuS–Pt (iv)–PEG–FA nanoparticles for targeted photothermal and chemotherapy. J. Mater. Chem. B, 2016, 4, 5938-5946. (IF 4.776)
  14. Huiting Bi, Yunlu Dai*(corresponding author), Ruichan Lv, Chongna Zhong, Fei He, Shili Gai, Arif Gulzar, Guixin Yang, Piaoping Yang*. Doxorubicin-conjugated CuS nanoparticles for efficient synergistic therapy triggered by near-infrared light. Dalton Trans., 2016, 45, 5101-5110. . (IF 4.099)
  15. Yunlu Dai, Xiaojiao Kang, Dongmei Yang, Xuejiao Li, Xiao Zhang, Chunxia Li, Zhiyao Hou, Ziyong Cheng, Ping’an Ma* and Jun Lin*. Platinum (IV) Pro-drug Conjugated NaYF4:Yb3+/Er3+Nanoparticles for Targeted Drug Delivery and Up-conversion Cell Imaging. Adv. Healthcare Mater. 2013, 2, 562-567. (IF 5.11) (Cover Paper)
  16. Junling Guo; Blaise L Tardy; Andrew J Christofferson; Yunlu Dai; Joseph J Richardson; Wei Zhu; Ming Hu; Yi Ju; Jiwei Cui; Raymond R Dagastine, Irene Yarovsky; Frank Caruso*, Modular assembly of superstructures from polyphenol-functionalized building blocks. Nature Nanotechnol. 2016, 11, 1105. (IF 38.986)
  17. Lili Feng; Shili Gai; Yunlu Dai; Fei He; Chunqiang Sun; Piaoping Yang*; Ruichan Lv; Na Niu; Guanghui An; Jun Lin*, Controllable Generation of Free Radicals from Multifunctional Heat-Responsive Nanoplatform for Targeted Cancer Therapy. Chem. Mater. 2018, 30, 526-539. (IF 9.890)
  18. Zhen Yang; Jibin Song; Yunlu Dai; Jingyi Chen; Feng Wang; Lisen Lin; Yijing Liu; Fuwu Zhang; Guocan Yu; Zijian Zhou; Wenpei Fan; Wei Huang; Quli Fan*, Xiaoyuan Chen* Self-assembly of semiconducting-plasmonic gold nanoparticles with enhanced optical property for photoacoustic imaging and photothermal therapy. Theranostics 2017, 7 , 2177. (IF 8.712)
  19. Lili Feng; Fei He; Yunlu Dai; Bin Liu; Guixin Yang; Shili Gai; Na Niu; Ruichan Lv; Chunxia Li; Piaoping Yang*, A versatile near infrared light triggered dual-photosensitizer for synchronous bioimaging and photodynamic therapy. ACS Appl. Mater. Interfaces 2017, 9 , 12993-13008. (IF 8.097)
  20. Ping’an Ma; Haihua Xiao; Chunxia Li; Yunlu Dai; Ziyong Cheng; Zhiyao Hou; Jun Lin*, Inorganic nanocarriers for platinum drug delivery. Mater. Today 2015, 18 , 554-564. (IF 24.537)
  21. Xiaoran Deng; Yunlu Dai; Jianhua Liu; Ying Zhou; Ziyong Cheng; Yinyin Chen; Kerong Deng; Xuejiao Li; Zhiyao Hou; Chunxia Li; Jun Lin*, Multifunctional hollow CaF2: Yb3+/Er3+/Mn2+-poly (2-Aminoethyl methacrylate) microspheres for Pt (IV) pro-drug delivery and tri-modal imaging. Biomaterials 2015, 50, 154-163. (IF 8.806)
  22. Ziyong Cheng; Yunlu Dai; Xiaojiao Kang; Chunxia Li; Shanshan Huang; Hongzhou Lian; Zhiyao Hou; Pingan Ma; Jun Lin*, Gelatin-encapsulated iron oxide nanoparticles for platinum (IV) prodrug delivery, enzyme-stimulated release and MRI. Biomaterials 2014, 35, 6359-6368. (IF 8.806)
  23. Dongmei Yang; Yunlu Dai; Pingan Ma; Xiaojiao Kang; Ziyong Cheng; Chunxia Li; Jun Lin*, One‐Step Synthesis of Small‐Sized and Water‐Soluble NaREF4 Upconversion Nanoparticles for In Vitro Cell Imaging and Drug Delivery. Chem. Eur. J 2013, 19, 2685-2694. (IF 5.16)
  24. Dongmei Yang; Yunlu Dai; Xiaojiao Kang; Mengmeng Shang; Ziyong Cheng; Chunxia Li; Jun Lin*, Synthesis of Li1−xNaxYF4:Yb3+/Ln3+(0≤ x≤ 0.3, Ln= Er, Tm, Ho) nanocrystals with multicolor up-conversion luminescence properties for in vitro cell imaging. J. Mater. Chem. 2012, 22 , 20618-20625. (IF 6.626)
  25. Zheyu Shen; Jibin Song; Zijian Zhou; Bryant C Yung; Maria A Aronova; Yan Li; Yunlu Dai; Wenpei Fan; Yijing Liu; Zihou Li; Huimin Ruan; Richard D. Leapman; Lisen Lin; Gang Niu; Xiaoyuan Chen*; Aiguo Wu* Dotted Core–Shell Nanoparticles for T1‐Weighted MRI of Tumors. Adv. Mater. 2018, 30, 1803163. (IF 21.950)
  26. Zijian Zhou*; Alexander Chan; Zhantong Wang; Xiaolin Huang; Guocan Yu; Orit Jacobson; Sheng Wang; Yijing Liu; Lingling Shan; Yunlu Dai; Zheyu Shen; Lisen Lin; Wei Chen; Xiaoyuan Chen*, Synchronous Chemoradiation Nanovesicles by X‐ray Triggered Cascade of Drug Release. Angew. Chem. Int. Ed. 2018, 57, 8463-8467. (IF 12.102)
  27. Huiting Bi; Fei He; Yushan Dong; Dan Yang; Yunlu Dai; Liangge Xu; Ruichan Lv; Shili Gai; Piaoping Yang*; Jun Lin*, Bismuth Nanoparticles with “Light” Property Served as a Multifunctional Probe for X-ray Computed Tomography and Fluorescence Imaging. Chem. Mater. 2018, 30, 3301-3307. (IF 9.890)
  28. Jibin Song; Xiangyu Yang; Zhen Yang; Lisen Lin; Yijing Liu; Zijian Zhou; Zheyu Shen; Guocan Yu; Yunlu Dai; Orit Jacobson; Jeeva Munasinghe; Bryant Yung; Gao-Jun Teng*; and Xiaoyuan Chen*, Rational design of branched nanoporous gold nanoshells with enhanced physico-optical properties for optical imaging and cancer therapy. ACS Nano 2017, 11, 6102-6113. (IF 13.709)
  29. Lili Feng; Shili Gai; Fei He; Yunlu Dai; Chongna Zhong; Piaoping Yang*; Jun Lin*, Multifunctional mesoporous ZrO2 encapsulated upconversion nanoparticles for mild NIR light activated synergistic cancer therapy. Biomaterials 2017, 147, 39-52. (IF 8.806)
  30. Zhen Yang, Wenpei Fan, Wei Tang, Zheyu Shen, Yunlu Dai, Jibin Song, Zhantong Wang, Yuan Liu, Lisen Lin, Lingling Shan, Yijing Liu, Orit Jacobson, Pengfei Rong, Wei Wang*, Xiaoyuan Chen*, Near-Infrared Semiconducting Polymer Brush and pH/GSH-Responsive Polyoxometalate Cluster Hybrid Platform for Enhanced Tumor-Specific Phototheranostics, Angew. Chem. Int. Ed. 2018, 57, 14101. (IF 12.102)
Research Grants
Start-up Research Grant (SRG) of University of Macau (SRG2018-00130-FHS).
Science and Technology Development Fund of Macao SAR (FDCT 0109/2018/A3).
  • “The National Scholarship” Award, 2007
  • “Outstanding Scholarship” Award, Harbin Engineering University, 2006-2009
  • “Merit Student” Award,  Changchun  Institute  of  Applied  Chemistry, Chinese Academy of Sciences, 2012 and 2013
  • “The National Scholarship” Award, 2013
  • “The Zhu Liyuehua Scholarship” Award, 2014
Professional Activities
Ad hoc reviewer:
Nature Communications. Advanced Materials, ACS Nano, Biomaterials, Chemistry of Materials, Journal of Controlled Release, Theranostics, ACS Applied Materials & Interfaces, Acta Biomaterialia, European Journal of Medicinal Chemistry, Chemical Engineering Journal, Chinese Chemical Letters