Contact Information
Research Team
Name Position Office Phone Email
Yongjie SUNPhD Student (Lab Representative)E12-1023+853 8822 2914yc17618@um.edu.mo
Dr. Liqiang ZHOUResearch Assistant ProfessorE12-1023+853 8822 2914liqiangzhou@um.edu.mo
Ling FENGPost-doctoral Fellow (Macau Young Scholar Program)E12-1023+853 8822 2914lingfeng@um.edu.mo
Ziyuan LIUPost-doctoral FellowE12-1023+853 8822 2914ziyuanliu@um.edu.mo
Jinxiao LYUPhD StudentE12-1023+853 8822 2914
Yanhong SUPhD StudentE12-1023+853 8822 2914
Fang LIUPhD StudentE12-1023+853 8822 2914
Zhichao WANGPhD StudentE12-1023+853 8822 2914
Lu ZHOUPhD Student
Peibin LIANGPhD Student
Hong LIUPhD Student
DSc University of Science and Technology of China (2004)
MSc Anhui University, China (2001)
BEng QiLu University of Technology, China (1998)
2020 – Present Associate Professor, Faculty of Health Sciences, University of Macau
2020 – Present Assistant Dean (Student Affairs), Faculty of Health Sciences, University of Macau
2015 – 2020 Assistant Professor, Faculty of Health Sciences, University of Macau
2011 – 2014 Assistant Professor, Linköping University, Sweden
Obtained Docent (equivalent to Associate Professor) in 2014.05
2010 – 2011 Visiting Scientist, University of Washington, USA
2009 – 2010 Post-doctoral Fellow, Linköping University, Sweden
2006 – 2009 Post-doctoral Fellow, National University of Singapore
2004 – 2006 Post-doctoral Fellow, Shantou University, China
Research Interests
Synthetic/Analytical Chemistry × Molecular Probes × Bioimaging and Sensing × Nanosensor × Nanomedicine
My research focuses on the development of chemical tools for biomedical research: (1) Synthesis of new molecular probes for targeted bioimaging/sensing and monitoring of biological processes; (2) Smart probes for theranostics and visualized therapy; (3) Nanoreactors and nanomedicine; (4) Abiotic synthesis in living systems. Chemistry is the central science. We use the knowledge of chemistry to resolve challenging problems in material sciences with the aim of biomedical applications.


Representative Publications
  1. C. Wang, Y. Sun, S. Huang, Z. Wei, J. Tan, C. Wu*, Q. Chen*, X. Zhang*(corresponding author), Self-Immolative Photosensitizers for Self-reported Cancer Phototheranostics, J. Am. Chem. Soc, 2023. 145, 13099−13113. (Front Cover Story)
  2. L. Zhou, J. Lyu, F. Liu, Y. Su, L. Feng, X. Zhang*(Corresponding author), PANoptosis-initiated Cancer Immuno-Reediting Therapy by Iteratively Boosting Cancer Innate Immunity Cycle, Adv. Mater. 2023, 2305361.
  3. D. Zhang, Y. Sun, Z. Wang, F. Liu, X. Zhang*(Corresponding author), Switchable biomimetic nanochannels for on-demand SO2 detection by light-controlled photochromism, Nature Communications 2023, 14:1901.
  4. Z.Zhang, Z. Wei, J. Guo, J. Lyu, C. Wang, L. Zhou, C. Wu, Z. Yuan, X. Zhang*(corresponding author), Metallopolymer Strategy to Explore Hypoxic Active Narrow-Bandgap Photosensitizers for Effective Cancer Photodynamic Therapy, Nature Communications 2023, NCOMMS-23-14171.
  5. L. Zhou, K. Li, Y. Liu, R. Zhang, Y. Yao, Q. Chen, D. Xie, X. Zhang*(Corresponding author), Living Cell-derived Intelligent Nanobots for Precision Oncotherapy, Adv. Funct. Mater., 2023, 202311857.
  6. D. Zhang, D. Liu, C. Wang, Y. Su, X. Zhang*(Corresponding author), Nanoreactor-based catalytic systems for therapeutic applications: principles, strategies, and challenges, Adv Colloid Interface Sci . 2023, 322, 103037.
  7. Y. Su, Z. Zhang, L. T. O. LEE, L. Peng, L. Lu,* X. He,* X. Zhang*(corresponding author), “Amphiphilic Dendrimer Doping Enhanced pH-Sensitivity of Liposomal Vesicle for effective co-delivery toward synergistic ferroptosis–apoptosis therapy of Hepatocellular Carcinoma”, Adv. Healthc Mater. 2023, 202202663.
  8. L. Zhou, W. Feng, Y. Mao, Y. Chen,* X. Zhang*(corresponding), Nanoengineered Sonosensitive Platelets for Synergistically Augmented Sonodynamic Tumor Therapy by Glutamine Deprivation and Cascading Thrombosis, Bioactive Materials 2023, 24, 26–36.
  9. D. Zhang, X. Zhang*(corresponding author), Aquaporin-Inspired CPs/AAO Nanochannels for Effective Detection of HCHO: Importance of Hydrophilic/Hydrophobic Janus for High-Performance Sensing. Nano Letters 2022, 22, 3793−3800.
  10. L. Zhou, W. Feng, H. Huang, S. Huang, Q. Chen*(corresponding author), X. Zhang*(corresponding author), Y. Chen*(corresponding author), Targeting Acidogenic Metabolism by Engineering Self-Catalytic siRNA Nanocarriers/Nanocatalysts for Amplified Tumor Apoptosis/Ferroptosis. Nano Today, 2022, 46, 101623.
  11. J. Gong, X. Zhang*(corresponding author), Coordination-Based Circularly Polarized Luminescence Emitters: Design Strategy and Application in Sensing, Coord. Chem. Review. 2022, 453, 214329.
  12. C. Wang, W. Wang, J. Tan, X. Zhang*(Corresponding author), D. Yuan,* H-C Zhou,* Coordination-based molecular nanomaterials for biomedically relevant applications, Coord. Chem. Rev. 2021, 438, 213752.
  13. J. Gong, R. Huang, C. Wang, Z. Zhao, BZ Tang, X Zhang*(corresponding author), Iodization-enhanced fluorescence and circularly polarized luminescence for dual-readout probe design, Sensors and Actuators B: Chem 2021, 347, 130610.
  14. D. Zhang, X. Zhang*(Corresponding author), Bioinspired Solid-State Nanochannels Sensor: From Ionic Current Signals, Current and Fluorescence Dual Signals to Faraday Current Signals, Small 2021, 2100495.
  15. S. Zhao, Y. Long, Y. Su, S. Wang, Z. Zhang*, X. Zhang*(Corresponding author), Cobalt-enhanced Mass Transfer and Catalytic Production of Sulfate Radicals in MOF-derived CeO2/Co3O4 Nanoflowers for Efficient Removal of Antibiotics, Small 2021, 2101393.
  16. S. Wang, Z. Sheng,* Z. Yang, D. Hu, D. Hu, X. Long, G. Feng, Y. Liu, Z. Yuan, J. Zhang, H. Zheng, X. Zhang*(corresponding author), Activatable Small-Molecule Photoacoustic Probes that Cross Blood-Brain Barrier for Visualization of Copper(II) in Mice with Alzheimer’s Disease, Angew. Chem. Int. Ed. 2019, 58, 12415-12419. (Selected as HOT article)
  17. B. Zhang, F. Wang, H. Zhou, D. Gao, Z. Yuan, C. Wu,* X. Zhang*(corresponding author), Polymer Dots Compartmentalized in Liposomes as Photocatalyst for In Situ Hydrogen Therapy, Angew. Chem. Int. Ed. 2019, 58, 2744-2748. (Selected as VIP article)
  18. J. Tan, C. Wang, HK Lao, W. Wang,* G. Feng, D. Yuan, C. Wu, X. Zhang*(corresponding author), Spiro[pyrrol-benzopyran] Based Probe with High Asymmetry for Chiroptical Sensing via Circular Dichroism, Chem. Commun. 2019, 55, 7438-7441.
  19. C. Wang, X. Cheng, J. Tan, Z. Ding, W. Wang, D. Yuan, G. Li, H. Zhang*, X. Zhang*(corresponding author), Reductive cleavage of C=C bond as a new strategy to turn on dual fluorescence for effective sensing H2S, Chemical Science 2018, 9, 8369–8374. (2018 Hot Article)
  20. S. Wang, Z. Li, Y. Liu, G. Feng, J. Zheng,* Z. Yuan,* X. Zhang* (corresponding author), Activatable Photoacoustic and Fluorescent Probe of Nitric Oxide for Cellular and in Vivo Imaging, Sensors and Actuators B: Chem 2018, 267, 403-411.
  21. Z. Ding, J. Tan, G. Feng, Z. Yuan, C. Wu, X. Zhang*(corresponding author), Nanoscale Metal-Organic Frameworks Coated with Poly(vinyl Alcohol) for Ratiometric Peroxynitrite Sensing through FRET, Chemical Science 2017, 8, 5101-5106.
  22. C-S Ke, C-C Fang, J-Y Yan, P-J Tseng, J R Pyle, C-P Chen, S-Y Lin, J Chen, Zhang*(co-corresponding author), Y-H Chan,* Molecular Engineering and Design of Semiconducting Polymers to Develop Polymer Dots with Narrow-Band, Near-Infrared Emission for In Vivo Biological Imaging, ACS Nano, 2017, 11, 3166-3177.
  23. X. Zhang*(corresponding author), W. Wang, Z. Hu, G. Wang, K. Uvdal,* Coordination polymers for energy transfer: preparations, properties, sensing applications, and perspectives, Coord. Chem. Rev. 2015, 284, 206-235.
  24. X. Zhang, J. Yu(co-first author), Y. Rong, F. Ye, D. T. Chiu, K. Uvdal, High-intensity near-IR fluorescence in semiconducting polymer dots achieved by cascade FRET strategy, Chemical Science 2013, 4, 2143-2151.
  25. X. Zhang, J. Yu, C. Wu, Y. Jin, F. Ye, D. T. Chiu, Importance of having low-density functional groups for generating high-performance semiconducting polymer dots, ACS Nano 2012, 6, 5429-5439.
  26. X. Zhang, MA Ballem, Z-J Hu, P. Bergman, K. Uvdal, Nanoscale Light-harvesting Metal-organic Frameworks, Angew. Chem. Int. Ed. 2011, 50, 5729-5733.
  27. X. Zhang, MA Ballem, M Ahrén, A Suska, P Bergman, K Uvdal, Nanoscale Ln(III)-carboxylate Coordination Polymers: Temperature-Controlled Encapsulation and Light Harvesting, J. Am Chem. Soc. 2010, 132, 10391-10397.
  28. X. Zhang, Z-K Chen, KP Loh, Coordination-Assisted Assembly of 1-D Nanostructured Light-Harvesting Anntea, J. Am. Chem. Soc. 2009, 131, 7210–7211.
  29. X. Zhang, X. Ren, Z-K Chen, Q-H Xu, KP Loh, One- and Two-photon Fluorescent Probe for Cysteine and Homocysteine with Large Emission Shift, Org. Lett. 2009, 11, 1257–1260.
  30. X. Zhang, D. Li, Metal Salts Induced Vesicles as Efficient Directors for Rapid Synthesis of Hollow Alloy Spheres, Angew. Chem. Int. Ed. 2006, 45, 5971–5974.

(* Corresponding Author)

Full Publication List: http://www.researcherid.com/rid/C-2131-2013
Research Grants
2023 – 2025 NSF-Guangdong Province (2023A1515012524)
2023 – 2024 Multi-year grant of UM (MYRG2022-00036-FHS)
2022 – 2023 NSF-Guangdong Province (2022A1515010616)
2022 – 2023 Multi-year grant of UM (MYRG2020-00130-FHS)
2021 – 2024 FDCT grant from Macau government (FDCT0085/2020/A2)
2019 – 2022 FDCT grant from Macau government (FDCT0114/2019/A2)
2020 – 2021 Multi-year grant of UM (MYRG2019-00051-FHS)
2018 – 2021 FDCT-MOST joint grant (FDCT019/2017/AMJ)
2018 – 2020 Multi-year grant of UM (MYRG2017-00066-FHS)
2017 – 2020 FDCT grant from Macau government (FDCT082/2016/A2)
2017 – 2019 Multi-year grant of UM (MYRG2016-00058-FHS)
2016 – 2018 FDCT grant from Macau government (FDCT052-2015-A2)
2015 – 2017 Start-up grant at University of Macau (SRG2015-00007-FHS)
2013 – 2016 Co-investigator, National Natural Science Foundation of China
2013 – 2014 CeNano grant, Linköping University
2012 Liu-cancer seeding grant, Linköping University
2005 Natural science foundation of Guangdong Province, China
2005 The China Postdoctoral Science Foundation
2004 Internal postdoc foundation, Shantou University
  • D.T. Chiu, C. Wu, X. Zhang, J. Yu, F. Ye, “Chromophoric Polymer Dots”, – PCT Patent. Publication No. WO 2012/054525 A2.
  • D. T. Chiu, C. Wu, X. Zhang, J. Yu, F. Ye, “Chromophoric Polymer Dots”, Publication No. 20130234067.
  • D. T. Chiu, C. Wu, X. Zhang, J. Yu, F. Ye, “Chromophoric Polymer Dots”, Publication No. 20130234068.
  • D. T. Chiu, C. Wu, Y. Rong, Y. Zhang, Y.-C. Wu, Y.-H. Chan, X. Zhang, J. Yu, W. Sun, “Chromophoric Polymer Dots with Narrow-Band Emission”, Publication No. 20140350183.
2022 Incentive Award Scheme for Outstanding Academic Staff, University of Macau
2019 FHS Best Teacher (Excellence in teaching)
2017 Incentive Award Scheme for Outstanding Academic Staff, University of Macau
2003 Donggang Scholarship, University of Science & Technology of China
Professional Activities
  • Guest Editor of “Nanomaterials” (IF 5.7), special issue: Fluorescent Nanomaterials for Sensing, Bioimaging, and Therapy, 2022-2023.
  • Lead Guest Editor of “BioMed Research International” 2015.
  • Member of International Frequency Sensor Association (IFSA)
  • Member of the Chinese Chemical Society
Pedagogy and Teaching
  • Three-level pedagogy for higher education, Linköping University, Sweden. (2012-2014).
  • Current topics in biomedical imaging 2015/2016 (PhD course)
  • Current topics in nanoprobes for bioimaging from 2016/2017 (PhD course)
  • General Chemistry, University of Macau, from 2015/2016. (Undergraduate course, 3 credits)
  • Chemistry lab course, University of Macau, from 2015/2016. (Undergraduate course, 2 credits)
  • Course Leader of “Materials for Biomedical Engineering: From Nano- to Macroscale”, at Linköping University, 2014. (Undergraduate course, 8 credits)
  • Basic Chemistry, at Linköping University, 2013. (Undergraduate course, 2 credits)